✨Sharing "Identification of bio psychological trait markers in functional neurological disorders"✨, published #OpenAccess in @Brain1878 with @LoukasSerafeim @SelmaAybek . Some of the highlights below 🧵. (1/16).

RT @braincomms: Weber et al. report that functional neurological disorder patients show interplay between oxytocin, OXTR methylation, and a….

🚀 Excited to share some work we do at the Psychiatric University Hospital Zurich! 🙌 We explored how large language models #LLM can support the generation of standardized psychiatric discharge summaries showing promise in reducing workload! 💻📑. ▶️

Check out the paper for more insights 🤓🧠💡!. A big thank to all patients & all contributors! . @unibern @inselgruppe @KKliniken @ruhrunibochum @NeuroEssen @clin_neurobern @MedFacultyUniBE @FNDSociety

💡In this light, our finding of increased LC-activity-related “state persistence” among two out of three CAPs could substantiate the presumed link between central noradrenergic activation and dissociation!.

💡Patients with reported loss of awareness often remain in a state of continuous erratic motor activity. These types of dissociative states could be related (if not attributed) to.an impairment in flexibility of switching between the default mode and attentional brain networks.

🔎 Patients entered CAP1 and CAP2 less often than healthy controls, and showed a higher state persistence (ie probability of staying in a certain CAP) for CAP2 and CAP3, respectively 🤔🤔!

🔎 The third CAP represents a LC activation pattern with co-activation of the executive control network and DMN; as well as co-deactivation of the Vis and DorsAttn.

🔎 The second CAP denotes an activation pattern with co-activation of the visual network (Vis) and the Sal/VenAttn; and a co-deactivation with the DMN and the executive control network.

🔎 The first CAP exhibits a LC co-activation predominantly with the default mode network (DMN); and a co-deactivation with the dorsal (DorsAttn) and salience/ventral attention networks (Sal/VenAttn).

To assess how LC activation affects global network activity we used co-activation pattern (CAP) analysis on N = 14 patients with dissociative seizures and N = 14 healthy controls using the LC as seed region.

🧠⚡️Dissociative seizures often occur immediately after a stressor, suggesting fast-acting arousal- mechanisms such as locus coeruleus (LC) activation.

👀 Check out our latest paper, published #openaccess in @EpilepsiaOpen !. This is the result of an incredible collaboration with @jungjoha, @SelmaAybek & @popkirov. It was a true pleasure working together to develop this project 🤩. ▶️

RT @quant_arb: Hawk Tuah recently went viral for her rant on the overuse of advanced machine learning models by junior quant researchers.….

Thanks again for all participants, all collaborators, our host and funding insitutions, and all the lovely co-authors🤍. @j_buehler_ch @SelmaAybek @inselgruppe @xenomica @unibern .@snf_ch.

For more details 🧠🧬 check out the paper 🤓 #openaccess!. All codes are published alongside the work on github🥸.

💡While genetic factors might play an important (potentially moderating) role in the development and.course of FND, other factors are also important contributors and should not be out of focus.💡.

This analysis suggested 1) a gene-gene interaction between TPH2 and OXTR to be implicated in the development and maintenance of FND symptoms, and 2) a synergistic effect of TPH1, TPH2 and BDNF on clinical outcome!.

4️⃣ Using a machine-learning based approach, we additionally investigated potential gene-gene interactions.

3️⃣ Interestingly, a genetic variant in the TPH1 gene was also associated with a worse/unchanged clinical outcome, suggesting that genes in the serotonin pathway might contribute to a susceptibility to stress-related disorders along with a potential effect of childhood trauma!.

2️⃣ Further, we found a significant interaction with the minor allele of TPH1 genetic variant and (low) childhood trauma. This - however - showed that patients who are major allele carriers with no/low childhood trauma scores had higher symptom severity🤔🤔🤔