@md1talk
One important Differential would be:
Nephrogenic diabetes insipidus induced by lithium
Clinically evident by polyuria
Laboratory evident by hypernatremia, ↑ osmolality and dilute urine
@md1talk
acE-i → dilate “E”fferent arteriole (the action of angiotensin 2 is to vasoconstrict the efferent) → ↓ GFR
NSIADs → ↓ prostaglandins → afferent vasoconstriction → ↓ GFR
@md1talk
Resistant HTN + Hypokalemia = primary hyperaldosteronism
“At least this is very true for exams sake”
First step is aldosterone/renin ratio.
Then confirmation is done by adrenal imaging (CT/MR)
@md1talk
Toxic megacolon
- Toxic = systemic inflammation (by labs and symptoms and signs)
-Megacolon = large colon
For antimicrobials = ciprofloxacin + metronidazole cocktail 🍹
Steroids is needed and a corner stone in therapy 🎖️
Evaluation for C .Diff and if + = oral vancomycin
@md1talk
Hypertensive crisis with ingestion of foods containing tyramine
- Examples: aged cheeses, smoked/cured meats, alcohol (beer & red wine)
- Tyramine stimulates sympathetic by releasing noradrenaline, from vesicles into the synaptic cleft →↑↑↑ BP
- seen with MAOi agents
@md1talk
If there are any serious complications:
- stop the infusion
- Cryoprecipitate (10 units) over (10min) and more as needed
- Antifibrinolytic: aminocaproic acid or tranexamic acid
@md1talk
Hyperkalemia with sine wave pattern
First & the most critical step in management is to give calcium gluconate to stabilize the cardiac membrane
@grepmeded
@md1talk
risk:
•Hyponatremia
•Cerebral edema
•Pulmonary edema
•Hyperglycemia
•Hypokalemia
Use in:
•Correction of free water deficit (hypernatremia)
•Maintenance fluid
•Solvent for IV drugs
This is a 7 year old child, his previous history reveal URTI 2 weeks ago, presenting now with a complain of symmetrical ascending paralysis started form his toes, the most appropriate management is ?
Steroids
Acyclovir
IVIG
Aspirin
@md1talk
In summary:
- if we halve the length→ flow will double
- if we halve the diameter→ flow will be reduced 16 times
Since central catheter length is longer than peripheral, peripheral will deliver more flow if we use the same gauge size
@md1talk
Acute angle closure glaucoma
Supine position may help to reduce IOP
IV/PO acetazolamide + parasympathomimetic eye drops and call ophthalmology
@md1talk
Torsade pointes
Causes think LONG QT:
- Lytes (↓ K, Ca+2, Mg+)
- Drugs
- Hypothermia
- Stroke, SAH
If they are stable, then Mg sulfate is the agent of choice (1-2g infused over 10min, then 1g/h infusion)
Unstable, need to be defibrillated
Smith-Modified Sgarbossa Criteria:
•Concordant STE ≥ 1 mm in ≥ 1 lead
•Concordant ST depression ≥ 1 mm in ≥ 1 lead of V1-V3
•Proportionally excessive discordant STE in ≥ 1 lead anywhere with ≥ 1 mm STE, as defined by ≥ 25% of the depth of the preceding S-wave
Gastroparesis occurs in patients with long-standing (eg, >5 years) diabetes mellitus and is most commonly seen in those with renal, ocular, or neurologic involvement.
Although all of these measures should happen in a certain time frame, when you see “STEMI” you need to think re-perfusion therapy (time is muscle and the vessel must be opened), so PCI is the answer here
In MCQs, choose according to best benefit if all answers were correct
Hypothyroidism can precipitate statin myopathy, and conversely statins can aggravate hypothyroid myopathy.
Therefore, many experts suggest screening for hypothyroidism prior to initiating statin therapy,
Patients with PAD & intermittent claudication have an estimated 20% 5-year risk of nonfatal MI & stroke and a 15%-30% risk of death due to cardiovascular causes
Patients presenting with acute diarrhea associated with steatorrhea should first be evaluated for infectious etiologies.
#Giardia
lamblia is the most common infectious cause of malabsorption and is diagnosed with stool microscopy or stool immunoassay.
#MedEd
#MedTwitter
The Drug of choice in anaphylaxis is Epinephrine ✅
The vasopressor of choice in septic shock is Norepinephrine ✅
Why ? Go back to the adrenergic receptors action
Hemolytic uremic syndrome typically occurs in children who have recently recovered from a diarrheal illness and who have acute renal injury, thrombocytopenia, and microangiopathic hemolytic anemia with schistocytes on peripheral smear
@drtimothyli
Melioidosis
Pathogen: B. pseudomallei
•Antimicrobial therapy
◦Initial intensive therapy: IV ceftazidime, imipenem, or meropenem for 10–14 days
◦Followed by eradication therapy: oral TMP/SMX (plus doxycycline) for 3–6 months
•Adjunct therapy: abscess drainage
@md1talk
1 = Aortic stenosis
2 = murmur radiates to carotids
3 = age (most common cause), bicuspid aortic valve
4 = surgical therapy is indicated in severe aortic stenosis with:
- Symptoms or
- EF < 50%
ARDS
During hospitalization, a conservative fluid strategy aimed at achieving a neutral or negative fluid balance accelerates recovery from ARDS, with a trend toward improved survival rate ("dry lungs = happy lungs").
Imagine that you are a medical student, and at the final exam you started to hyperventilate, then you felt a dizziness and tingling in your hands
What are the pathophysiologic mechanisms responsible for your dizziness and tingling ?
Fever + headache + photophobia + neck stiffness are an overlapping clinical features between subarachnoid hemorrhage (SAH) & meningitis
In SAH, the fever is usually a low grade !
66y old man, smoker and alcoholic, present with recurrent vague abdominal pain for months, current labs shows diabetes, stool reveals elevated fecal fat
What is the diagnosis🤔⁉️
Cerebral Perfusion Pressure (CPP) = MAP - intracranial pressure (ICP)
↑ in ICP -> reduce the CPP, so the BP have to compensate and ↑↑
This explains the hypertension in ↑ ICP
60y male known case of DM and hypertension present with hemoptysis, fever and night sweats
“Next” step in management ?
A)Blood cultures
B)Isolation
C)Start Anti-TB
From the following agents, which will likely improve mortality in cirrhotic presenting with active variceal bleeding 🩸?
A)Ceftriaxone
B)Nitroglycerin
C)Erythromycin
Sokolow-Lyon criteria
LVH is suspected if either of the following criteria are met:
The sum of the S wave in lead V1, and the R wave in either lead V5 or 6
Is 35 mm or more
The R wave in lead aVL is > (11 mm)
LR is preferred in burn patients, as these patients often require large volumes of fluids, LR will help you to avoid hyperchloremic acidosis which may happen with large volumes of normal saline
Morbilliform drug eruption 💊
-Type IV hypersensitivity reaction -Caused by drugs (anticonvulsants, antibiotics)
-Occur 5-21 days following drug initiation.
-Erythematous macules & papules, distributed symmetrically on the trunk and extremities
-Mucosal involvement is absent