One of the biggest reasons why we need antibiotic stewardship is to avoid creating scary monsters like this⬇️ How are you going to treat this?

Female sex has been identified as a risk factor for mortality in S.aureus BSI. What about other BSI? In this systematic review and meta-analysis, females with GN-BSI were NOT at higher risk of mortality than males after statistical adjustment. https://t.co/IIQ54omrfe

How to approach a patient hospitalized for pneumonia who is not responding to treatment? ➡️Differential diagnosis ➡️Diagnostic workup ⚠️Escalating antibiotic treatment should not be the default option https://t.co/T6WVReXSU9

The spectrum of diagnostic tests available for invasive fungal disease https://t.co/dpi0zAzE8G

🆕🔥State-of-the-Art Review with 🌟s @TrubianoJason : Antibiotic Allergy—A Multidisciplinary Approach to Delabeling #IDXposts https://t.co/zA3lpZzvvw

The combination of echinocandins with TMP/SMX may reduce mortality in HIV-infected patients with pneumocystis pneumonia, but does not appear necessary in non-HIV. ⚠️All 7 studies included were retrospective and from Asia ⚠️Only 2 studies contained HIV+ https://t.co/OmihdiUO9R

🆕🔥🔥CloCeBa RCT Cloxacillin versus cefazolin for MSSA Bacteraemia Cefazolin has a non-inferior efficacy regarding mortality, microbiological or clinical endpoints and was associated with a lower rate of serious adverse events #IDXposts Thanks @Inox94 https://t.co/1KtZVqZ2hg

Prevalence of Positive Penicillin Allergy Testing in Hospitalized Adult Patients ➡️SRMA of 46 studies ➡️Pooled prevalence of positive PST: 3.15% ➡️Pooled prevalence of positive DOC: 1.19% 🌟Most penicillin allergy labels can be delabeled (by DOC+/-PST) https://t.co/MLHgDbRgL3

Update Guidelines on Occupational HIV PEP 🔑Recommendations: -Start PEP ASAP and within 72hrs -Preferred: BIC/FTC/TAF or DTG/XTC/TXF, for 28 days -Final test at week 12 -Shared decision making (forgo PEP or stop early) if source has undetectable HIV RNA https://t.co/wQsAvRcuNM

Colour-COPD RCT from 🇬🇧 Use of sputum colour chart is unlikely to be a useful addition to usual care for guiding antibiotic self-treatment in COPD in primary care Sputum colour did not relate well to bacterial load Caution: severe under-recruitment https://t.co/bTwQtndxoo

Radiologic and pathologic findings from a fatal pneumocephalus case caused by hypervirulent Klebsiella pneumoniae in 🇩🇪 The patient also had pneumonia, liver and prostate abscesses, and septic shock https://t.co/kBKg95BZDI

Recommended treatment regimens for select sexually transmitted enteric pathogens https://t.co/ovk75cCZEe

CSF testing for suspected neurosyphilis ➡️isolated ocular or otic features: LP not needed ➡️CSF VDRL: specific but not perfectly sensitive ➡️CSF treponemal test: high negative predictive value, for cases with high suspicion despite negative CSF VDRL https://t.co/JYrs2B0yDY

Direct oral challenges are a safe and effective strategy for delabeling low-risk cephalosporin allergy labels in adults in the outpatient setting. https://t.co/Bv4UxXwFnd

Molecular mechanisms underlying cefiderocol treatment failure in A. baumannii 💣Point mutations in TonB iron receptors 💣Two-component system (TCS)-mediated upregulation of the MacAB-TolC efflux pump 💣β-lactamase-mediated hydrolysis https://t.co/JncBFbciDI

🆕🔥State of art review with 🌟s @JF_Timsit @jasonroberts_pk Antibiotic therapy for severe bacterial infections 🟢When to start and not to start antibiotics? 🟢Mon vs combo Abx 🟢PK/PD principles 🟢Drug–drug inx A #mustread article for ID professional https://t.co/99X5ozFcUk

Anti-interferon-γ autoantibodies (AIGAs) syndrome is a rare, adult-onset immunodeficiency characterized by ⬆️susceptibility to various opportunistic infections (E.g. disseminated NTM, talaromyces, salmonella) Pathogenesis and commonly affected organs👇🏻 https://t.co/c2QzRntt2L

Streptococcal endocarditis and strep species https://t.co/RujvQRAfNB The ‘small five’ streptococci: S. mutans, S. cristatus, S. gordonii, S. gallolyticus, & S. sanguinis account for only 8% of bloodstream infections but nearly 40% of strep IE @gushamilton @ABsteward

A clinical practice guideline for tuberculous meningitis @TheLancetInfDis ➡️Diagnostic approach ➡️Treatment and follow-up https://t.co/yF0Yrnyud9

This retrospective cohort from 🇫🇷showed that oral switch is a suitable option for treating IE, even for POET-ineligible patients ➡️treatment failure HR=0.55 favoring oral, 95%CI 0.27-1.17 ➡️more days alive outside 🏥 in oral group (59 vs 47, p=0.001) https://t.co/pECygLuhbY

Amoxicillin crystalluria (AC) and amoxicillin-induced crystal nephropathy (AICN): a narrative review ➡️pathophysiology ➡️step-by-step diagnosis HDIVA = high dose IV amoxicillin (≥150 mg/kg or ≥8 g per day) https://t.co/Jm3vCCyd9m