Robert McGeachan
@Rob_McGeachan
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Veterinary Clinical PhD Student @EdinburghUni & @UKDRI. Investigating the mechanisms of tau propogation. Yes, dogs and cats get dementia too.
Edinburgh, Scotland
Joined November 2021
🔔 🔔 🔔 New preprint! 🔔 🔔 🔔 Excited to share our latest study, where we observe increased synaptic engulfment by microglia and astrocytes around amyloid-β plaques in aged cats with cognitive dysfunction syndrome. https://t.co/O1FgF0GlLa
biorxiv.org
Feline cognitive dysfunction syndrome (CDS) is an age-related neurodegenerative disorder, comparable to dementia in people, characterised by behavioural changes such as increased vocalisation,...
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Outside of my science life, I spend a lot of my time playing, umpiring and coaching field hockey. I was lucky to have been photographed as part of a campaign to get more people into sport to help with their mental health 🏑 Go join some sport!
Today we launch the Find Your Team campaign in partnership with @SAMHtweets and @YoungScot. 🌤️As we settle into new routines after the busy summer months, sport and physical activity can play a big role in building social connection and reducing feelings of isolation.
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Our work on blood-based inflammation markers in FTLD is published! We found a pro-inflammatory cytokine profile in patients that is associated with central inflammation and worse survival outcomes. Huge thanks to all families, colleagues and funders! https://t.co/HLlcVJH5C8
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I'm not sure what the collective noun for undergraduates is....but huge thanks to @NathanRJRockley, Hannah McAlister and Adharsh Prasad - this wouldn't have been possible without your many hours on the microscope! And of course @Jamie_Rose81 for staining 100s of slides
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Great to see this work finally online! 🚀 Well worth a read if you're interested in tauopathies! This was a true collaborative effort. Massive thanks to everyone involved, especially to @TSpiresJones and @odando for their significant contributions!
Our new paper showing synaptic gene expression changes in frontotemporal dementia due to the MAPT 10 + 16 mutation is out now in Neuropathology and Applied Neurobiology - well done team!!
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New Preprint from Prof Giles Hardingham's lab @UKDRI Including beautiful synapse data from @KristjanHolt showing microglia are not essential for plaque-associated synapse loss in mice but do influence amyloid pathology deposition https://t.co/cbfpKrpxq1
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One of our researchers, @TSpiresJones, has been given the Inge Grundke-Iqbal Award for her work in Alzheimer’s! Great to see our researchers on the global stage at the world’s largest dementia conference. #AAIC2024 Congratulations on your prize Tara!
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Congratulations to @TSpiresJones, the #AAIC24 recipient of the Inge Grundke-Iqbal Award for Alzheimer's Research. This award is presented to the senior author of the most impactful study published in Alzheimer’s research in the two calendar years preceding AAIC.
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Today I will be presenting at #FENS2024 14:00 - 17:30 poster session. If you're interested in synaptic pathology in primary tauopathies or using human brain slice cultures come and say hi🙋♂️Preprints below: https://t.co/euzxn3eIN1
https://t.co/qZbym3gxYm
https://t.co/Hca9Kgnoa0
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🚨We're hiring!! 📢 We are looking for a postdoc to study the impact of astrocyte pathologies in iPSC models of FTD-tau. Come join us! 👇👇👇 https://t.co/wi4pCA1ckR
@UKDRI @EdinUniNeuro
elxw.fa.em3.oraclecloud.com
A postdoctoral research fellow position is available in Dr. Kathryn Bowles’ lab at the University of Edinburgh UK DRI centre. We are looking for a researcher interested in investigating the functio...
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Amazing work from @TSpiresJones @ClaireDurrant1 @Rob_McGeachan on synaptic pathology in #PSP at #Tau2024 - transsynaptic coupling of oligomeric Tauopathy and astrocytic engulfment. Inspirational and innovative use of human brain donation @UKDRI
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We are very concerned to note that, since the publication of the CMA report earlier today, there has been a worrying spike in abusive behaviour and harassment by some animal owners towards vets, vet nurses and practice colleagues. Read our full statement: https://t.co/6Qt65WYdxt
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Such cool data from the amazing @ClaireDurrant1 lab! Glad I was able to help a bit with this important work showing opposing roles of physiological and pathological amyloid-β on synapses in live human brain slice cultures https://t.co/cZIZsNao2P
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Check out our work studying the affects of amyloid-β on living human brain slice cultures! This work was very much a team effort, so big thanks to everyone involved! @DrSorayaM @ClaireDurrant1 @TSpiresJones @ScotsFriction @L_W_Taylor
https://t.co/euzxn3eIN1
biorxiv.org
In Alzheimer’s disease, it is theorised that amyloid beta (Aβ) and tau pathology contribute to synapse loss. However, there is limited information on how endogenous levels of tau and Aβ protein...
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Simply stunning work from @Rob_McGeachan, @ClaireDurrant1 and @TSpiresJones et al Brilliant use of living resected human tissue to complement post mortem tissue Fig 3 especially interesting (Formatted for high impact? let's hope so) https://t.co/Fs6A1hWqy8
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Very excited to share our preprint investigating mechanisms of synapse loss and disease progression in progressive supranuclear palsy. This work wouldn't have been possible without the expert guidance of @TSpiresJones and @ClaireDurrant1
https://t.co/qZbym3gxYm
medrxiv.org
In the neurodegenerative disease Progressive Supranuclear Palsy (PSP), tau pathology progresses through the brain in a stereotypical spatiotemporal pattern, and where tau pathology appears, synapses...
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Check out our latest preprint from the brilliant @Rob_McGeachan co-led with my science buddy @ClaireDurrant1 Evidence for trans-synaptic spread of tau in PSP and live human brain slices! #TeamTau
https://t.co/BJocYsqBwl
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