Renhao Profile
Renhao

@Renhao4

Followers
91
Following
614
Media
5
Statuses
46

PhD student @scrippsresearch | Previously @HarvardDBMI + @mghcvrc + @MonteRosaTx | He/Him/His

San Diego, CA
Joined January 2018
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@Renhao4
Renhao
1 month
I'm glad to be part of this and excited to see how the story unfolds from start to finish! Congrats everyone!.
@WrannLab
Christiane Wrann, PhD, DVM
1 month
Our latest study is out in Nature Neuroscience! 🧠💪We dissected protective exercise responses in the dentate gyrus in Alzheimer's disease at single-cell resolution. Proud of the team's hard work and collaboration! 🔗 @mghcvrc @NR_Tucker @MGBResearchNews.
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@Renhao4
Renhao
10 days
RT @markus_warmuth: Over the last 6 years we @MonteRosaTx have pushed the limits on molecular glue degrader design. The term MGD didn’t eve….
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@Renhao4
Renhao
10 days
RT @ScienceMagazine: New research in Science greatly expands the potential target scope of molecular glues and should stimulate the develop….
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@Renhao4
Renhao
24 days
RT @chiragjp: Heartbroken to share my mentor & friend Dr. Atul J. Butte @atulbutte has passed. He saw potential in me and turned it into o….
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@Renhao4
Renhao
24 days
RT @NatureNeuro: Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-seq….
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@Renhao4
Renhao
1 month
RT @MassGeneralNews: While exercise has long been known to benefit the brain, the specific cells responsible remained unclear—until now. Le….
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@Renhao4
Renhao
7 months
RT @Antihebbiann: Interested in diffusion models, behavior forecasting, internal states, neuromechanical modeling, reservoir computing, joi….
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@Renhao4
Renhao
8 months
RT @chiragjp: Looking to hire scientists (at all levels) to develop new computational models and AI approaches to map the exposome! Data ac….
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@Renhao4
Renhao
10 months
RT @ForliLab: Our second years @AllisonBarkdull, @YutingZhan8328, and @Renhao4 received lab coats this weekend! #computationalscientists #w….
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@Renhao4
Renhao
1 year
RT @chiragjp: Haven't we learned anything about stopping pandemics? When it comes to government policy and COVID-19, the answer is: "no, we….
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@Renhao4
Renhao
1 year
RT @BMCMedicine: Evaluation of the heterogeneity of odds ratios for 12 risk factors reported from the Lancet 2020 report and two non-modif….
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@Renhao4
Renhao
1 year
RT @chiragjp: 1/2 In 2020, a Lancet report highlighted 12 modifiable key risk factors for #dementia (e.g., traumatic brain injury [TBI], ai….
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@Renhao4
Renhao
1 year
(7/8) We identified and quantified sources of analytic heterogeneity in dementia risk factors, potentially due to different etiologies or misclassifications. Multivariate regression is crucial for independent estimates. Unclear how intervening on factors might alter risk.
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@Renhao4
Renhao
1 year
(6/8) Unattributed participants (with a dementia diagnosis but not specified subtype) correlated more with frontotemporal dementia in midlife and with vascular dementia and Alzheimer's in late life based on risk factor profiles.
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@Renhao4
Renhao
1 year
(5/8) We also observed heterogeneity in odds ratios for each risk factor between different dementia outcomes.
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@Renhao4
Renhao
1 year
(4/8) To test robustness, we ran an additional SCA with different combinations of selected risk factors (APOE e4/e4, TBI, Depression, Hypertension, Education, Diabetes) and demographic adjustments for each age group. Most factors, except diabetes, showed robust associations.
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@Renhao4
Renhao
1 year
(3/8) APOE e4/e4 and TBI showed the most robust associations, and risk factors like diabetes had fluctuating associations across dementia subtypes and analytic scenarios in SCA.
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@Renhao4
Renhao
1 year
@HarvardDBMI @BMCMedicine (8/8) A heartfelt thank you to @chiragjp for guiding me and brainstorming project ideas. And thanks to all the collaborators for their constructive suggestions on this project. @DenaZera @MariaGlymour @randalljellis @Hossein_Estiri.
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@Renhao4
Renhao
1 year
@HarvardDBMI @BMCMedicine (2/8) We used phenotypical, genomic, and diagnostic data from the UK Biobank, grouping dementia participants into midlife and late-life groups. We included various demographics and risk factors in models for each age group, comparing odds ratios in the SCA.
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@Renhao4
Renhao
1 year
I am thrilled to announce that my master project @HarvardDBMI is out in @BMCMedicine today! We studied the robustness of different dementia risk factors across subtypes and scenarios using Specification Curve Analysis (SCA) in the UK Biobank. (1/8).
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