Beyond excited to share that my first-author paper on Saturation Genome Editing of RAD51C is now published in @CellCellPress! Immensely proud of this enormous team effort, led by Andrew Waters and @David_J_Adams 1/8 .

RT @David_J_Adams: Well here I am making good on my promise to @RebecaOLE_ that if her paper got published then I would dye my hair purple….

RT @CellCellPress: Now online! High-resolution functional mapping of RAD51C by saturation genome editing

RT @David_J_Adams: Congrats to @RebecaOLE_ and Andrew Waters for delivering this one. Thanks also to the patients and our team collaborator….

And special thanks to @Christian_moli_ for all the training and support. I'm still practicing everything I learned from you - This is also yours! 8/8.

I worked on this amazing project during my Master’s, and reaching this point wouldn’t have been possible without @daniela_oaks. Thank you, Dani, for everything you’ve done and continue to do! Very honoured and proud to come from your lab and keep collaborating 💜 7/8.

This work will transform the diagnosis and clinical management of breast and ovarian cancer patients found to carry VUS in this gene. Many thanks to everyone involved! 💫 6/8.

We mapped our data onto protein structure of RAD51C in the context of paralogy complexes and we identified previously uncharacterised residues critical for function, which will lead to further molecular insights into RAD51C activity. 5/8.

We aimed to explore RAD51C’s biology using data from the UK Biobank % a large ovarian cancer group. We found that LoF variants in RAD51C are linked to hormone-driven cancers & we also identified specific missense variants associated with ovarian cancer risk. 4/8.

We not only discovered deleterious variants that show distinct and predictable biological patterns, but we also identified enriched variants with cellular behaviours that suggest positive selection and hyper-complementation. 3/8.

In this study, we functionally evaluated 9,188 RAD51C variants and classified over 3,000 of them as disruptive with accuracy of >99.9% based on truth sets. We observed specific missense variants exhibit distinct depletion kinetics, potentially representing hypomorphic alleles.2/8.

RT @daniela_oaks: Massive congratulations to @RebecaOLE_ on the publication of her first-author paper in @CellCellPress! Rebe did her under….

RT @David_J_Adams: Well done to Andrew Waters from the lab for delivering our study on saturation editing of BAP1.

RT @daniela_oaks: Excited to have official confirmation from @wellcometrust of our Career Development Award! This will support our lab's wo….

RT @David_J_Adams: ⁦.@RebecaOLE_ has submitted her 1st paper. Proud PI moment ;) .⁩

RT @humsav: 1/ Pre-print alert! Our new study led by talented @StanfordMed student @SavchukSol together with @michelle_monje illustrates th….

RT @TheGenomeLab: Our newly minted review led by Crick PhD student Phoebe Dace puts the research we do in the context of clinical variant i….

RT @David_J_Adams: The Mexican connection from my lab @RebecaOLE_ @tatinhawk @daniela_oaks (missing @JorgeBuendiaB and @xIbarraSoria). Una….

RT @David_J_Adams: Bienvenida a Rebe de México al Instituto Sanger como estudiante de M.Phil !! Otra gran colaboración con @LIIGH_UNAM http….

RT @daniela_oaks: I am so happy this is out now! In this piece, I tell my experience moving to Mexico from the UK five years ago, write abo….