Ramya
@RamyaSingh
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Developmental Biologist. RTs are mostly bookmarks for reading later.
Socorro, NM
Joined May 2009
RT @PLOSGenetics: Mutations in GLP-1, a Notch receptor, can result in #tumor formation. Singh et al @dhansen01 show that reduction of Derli….
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Very pleased to have been able to support open-access publishing! ❤️ Tagging Twitter-present co-authors @dhansen01 and @Chriswang1689. Thank you reviewers and editors for your time! 🙏🙏🙏 6/6.
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Reducing Derlin activity and/or inducing ER stress could potentially be a way to reduce the effect of Notch(gf)- dependent overproliferation/tumours.💊🚑👩⚕️ 5/6.
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However reduction of Derlin activity did not strongly enhance a Notch(loss-of-function) phenotype. It didn't suppress overproliferation in general either! We think this suppression applies to certain Notch(gf) alleles, specifically. 🎯 4/6.
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We think the Unfolded Protein Response(#UPR) triggered by loss of Derlins, and in conditions of ER stress, serves as a protective mechanism to correct Notch(gf) overproliferation, since reducing the activity of the UPR, reversed this suppression. 🧯💪3/6.
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Reduction in Derlin activity reduced the increased spread of SYGL-1, a read out for #Notchsignalling in a Notch(gain-of-function) background. Similar suppression was also seen when we induced ER stress by chemicals.✋🛑 2/6.
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📣 🎉Very happy to share our work, out now in @PLOSGenetics We found that loss of Derlin proteins, best known for their role in ER-associated degradation(#ERAD), suppress Notch-dependent overproliferation in the C.elegans germ line 🎉📣. 1/6.
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RT @SandraBLemke: How do dynamic changes in cell packing shape epithelial tissues during #morphogenesis? Read our review in @CurrentBiology….
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RT @jytinevez: A 2nd post about the new #TrackMate version:.Using TrackMate to segment 3D objects using a slice-by-slice approach. 1/n ht….
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RT @SarahMcc_in_140: Fluorescence imagers of Twitter. What's your favourite 5-colour palate for microscopy images. Ideally something colour….
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RT @Micropub7n: The primordial germ line is refractory to perturbations of actomyosin regulator function in C. elegans L1 larvae #micropubl….
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RT @natfriedman: We’ve just added built-in citation support to GitHub so researchers and scientists can more easily receive acknowledgments….
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RT @psobolewskiPhD: If you want to try @napari_imaging maybe with #clEsperanto or #TensorFlow plus #StarDist NATIVE on your #AppleSilicon….
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RT @MatiCalderini: @Pi_In_The_Sky @matplotlib I am biased but. I think my #matplotlib tutorials are quite good. I should have a pandas on….
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The bulk of my PhD work is out! Characterizing a suppressor of a strong Notch-dependent over-proliferation phenotype (aka tumour) lead us to uncover the role of ER-associated degradation proteins (#Derlin) and the Unfolded Protein Response. #ERAD #UPR #ERstress #stemcells.
Reduction of Derlin activity suppresses Notch-dependent tumours in the C. elegans germ line #bioRxiv.
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RT @eLife: 3DeeCellTracker is a versatile new tool that uses artificial intelligence to identify and follow cells in microscopy images and….
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The focus needed to cut baby nails makes me feel like I'm doing dissections or microinjections in the lab again. except now I'm using an ultra, mega sleep-deprived brain! 😂.
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Off on maternity leave for the next several months. Thank you Canadian Tri-Council funding agencies (particularly .@CIHR_IRSC) for enabling one year paid mat leaves for trainees and PIs. Pic courtesy @agerholdlab.
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RT @damiandn: If anyone's doing cell tracking/lineage tracing or anything that would benefit from a really great tracking/track editing pro….
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