Ramya
@RamyaSingh
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Developmental Biologist. RTs are mostly bookmarks for reading later.
Socorro, NM
Joined May 2009
Mutations in GLP-1, a Notch receptor, can result in #tumor formation Singh et al @dhansen01 show that reduction of Derlin activity suppresses over-proliferation due to GLP-1/Notch mutations in C. elegans #CancerResearch 🔎 Learn more: https://t.co/nCMHMBxT9b 📷: @RamyaSingh
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Very pleased to have been able to support open-access publishing! ❤️ Tagging Twitter-present co-authors @dhansen01 and @Chriswang1689. Thank you reviewers and editors for your time! 🙏🙏🙏 6/6
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Reducing Derlin activity and/or inducing ER stress could potentially be a way to reduce the effect of Notch(gf)- dependent overproliferation/tumours.💊🚑👩⚕️ 5/6
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However reduction of Derlin activity did not strongly enhance a Notch(loss-of-function) phenotype. It didn't suppress overproliferation in general either! We think this suppression applies to certain Notch(gf) alleles, specifically. 🎯 4/6
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We think the Unfolded Protein Response(#UPR) triggered by loss of Derlins, and in conditions of ER stress, serves as a protective mechanism to correct Notch(gf) overproliferation, since reducing the activity of the UPR, reversed this suppression. 🧯💪3/6
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Reduction in Derlin activity reduced the increased spread of SYGL-1, a read out for #Notchsignalling in a Notch(gain-of-function) background. Similar suppression was also seen when we induced ER stress by chemicals.✋🛑 2/6
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📣 🎉Very happy to share our work, out now in @PLOSGenetics
https://t.co/U5Zj1t13WL. We found that loss of Derlin proteins, best known for their role in ER-associated degradation(#ERAD), suppress Notch-dependent overproliferation in the C.elegans germ line 🎉📣. 1/6
journals.plos.org
Author summary Notch signaling is a highly conserved signaling pathway that is utilized in many cell fate decisions in many organisms. In the C. elegans germline, Notch signaling is the primary...
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How do dynamic changes in cell packing shape epithelial tissues during #morphogenesis? Read our review in @CurrentBiology to find out what strategies cells use to create the beautifully diverse shapes of organs. @celestemnelson @EPrinceton @Princeton
https://t.co/IFDBqe1WRT
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A 2nd post about the new #TrackMate version: Using TrackMate to segment 3D objects using a slice-by-slice approach. 1/n
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Fluorescence imagers of Twitter. What's your favourite 5-colour palate for microscopy images. Ideally something colourblind friendly that is clear without single panels #anotherfelllowshipapplication
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The primordial germ line is refractory to perturbations of actomyosin regulator function in C. elegans L1 larvae #micropublication #biology #data #newfinding #celegans
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We’ve just added built-in citation support to GitHub so researchers and scientists can more easily receive acknowledgments for their contributions to software. Just push a CITATION.cff file and we’ll add a handy widget to the repo sidebar for you. Enjoy! 🎉
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If you want to try @napari_imaging maybe with #clEsperanto or #TensorFlow plus #StarDist NATIVE on your #AppleSilicon Mac, I've finally written up some directions: https://t.co/yP1Jw25wZZ Good luck! #BioImageAnalysis
Got the #StarDist @napari_imaging plugin working #AppleSilicon native too—wasn't intuitive, but worked... The #Python code way was fine for me—probably best to get more comfortable with 🐍, but a GUI certainly makes life easier for a quick one-off. #TensorFlow #BioImageAnalysis
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@Pi_In_The_Sky @matplotlib I am biased but... I think my #matplotlib tutorials are quite good. I should have a pandas one coming out soon as well: https://t.co/dnWLaL2pkU
https://t.co/VhLN5kON3w Good luck!
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The bulk of my PhD work is out! Characterizing a suppressor of a strong Notch-dependent over-proliferation phenotype (aka tumour) lead us to uncover the role of ER-associated degradation proteins (#Derlin) and the Unfolded Protein Response. #ERAD #UPR #ERstress #stemcells
Reduction of Derlin activity suppresses Notch-dependent tumours in the C. elegans germ line https://t.co/H2bP201Bjw
#bioRxiv
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3DeeCellTracker is a versatile new tool that uses artificial intelligence to identify and follow cells in microscopy images and can now be used across biology, medical research and drug development to help monitor cell activities https://t.co/yEk1qa8jH3
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The focus needed to cut baby nails makes me feel like I'm doing dissections or microinjections in the lab again...except now I'm using an ultra, mega sleep-deprived brain! 😂
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Off on maternity leave for the next several months. Thank you Canadian Tri-Council funding agencies (particularly @CIHR_IRSC) for enabling one year paid mat leaves for trainees and PIs. Pic courtesy @agerholdlab.
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If anyone's doing cell tracking/lineage tracing or anything that would benefit from a really great tracking/track editing program, I really recommend mastodon. It's still in alpha, but seems pretty rock-solid to me so far. https://t.co/egzABxZAuT
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