Samira Musah
@ProfSamiraMusah
Followers
1K
Following
1K
Media
49
Statuses
657
Asst Prof, #MusahLab @DukeU #BME #Medicine @DukeMEDx, Alumnus @Harvard & @KiesslingGroup || Stem cells, disease models, therapeutics. Bluesky: @StemCellEngineer
Durham, NC
Joined September 2015
I am tremendously grateful to receive the 2023 @NIH Director's New Innovator Award to develop new therapeutic modalities for degenerative glomerulopathies. Many thanks to my mentors, trainees, family, and friends for their support/contributions to this journey. Onward! @MusahLab.
Early-stage investigators proposed innovative high-impact research ideas for the @NIHDirector’s New Innovator Award. See the projects the awardees will pursue: #NIHHighRisk
37
32
308
Sophia dives into some of our work using human stem cell derivatives to engineer patient-specific preclinical models, helping us uncover disease mechanisms and identify new and safe therapeutics.
1
1
1
Check out this new #TEDx talk by an inspiring #MusahLab undergraduate researcher and recent @DukeU graduate, Sophia Leeman! #STEM #BiomedicalEngineering #PatientSpecificModels #StemCells #PreclinicalModels #MPS
1
3
6
Congratulations to #MusahLab graduate student Yize (Eon) Zhang for leading this work from our team exploring the interface between biomaterials and cell biology! #tissuemodels #mechanobiology #stemcellresearch #tissueengineering #Bioengineering #YAP #synaptopdin #hydrogel.
0
0
1
These findings provide a step towards designing better environments for studying podocyte biology and could have implications for improving tissue engineering and kidney disease modeling.
1
0
1
This could explain why traditional/extremely rigid tissue culture substrates often fail to model in vivo-like biological responses in cultured podocytes.
1
0
0
(2) BUT, the cells adopt functional phenotypes when these YAP-activating matrices are compliant—promoting flexible cytoskeletal arrangements instead of rigid architectures.
1
0
0
We showed that:.(1) Podocytes—a specialized/post-mitotic cell type found in the kidney's blood filtration unit—prefer matrices that activate YAP, a protein linked to mechanotransduction.
1
0
0
we explored how visceral epithelial cells (podocytes) respond to ECM cues in unexpected ways. Many researchers rely on changes in cell shape or F-actin polymerization to infer how cells respond to matrix elasticity, but these conventional indicators can sometimes be misleading.
1
0
0
Latest research publication from our lab reveals a role for YAP-activating hydrogels in stem cell-derived podocyte differentiation and molecular-level specialization. Full Paper: Here's what we found:
1
1
20
RT @VollumInstitute: The Vollum Institute is accepting applications for multiple faculty openings. We are interested in individuals whose r….
0
47
0
Check out some of our related work using biomaterial platforms to guide stem cell differentiation and self-renewal and tissue development, function, and disease: .
1
0
2
In this paper, we highlight the potential of biomaterials to move the field forward.
1
0
2
This article was inspired by our interest & commitment to advancing understanding of human biology by harnessing the translational power of stem cells & personalized organoid models to bring life-saving therapeutics to patients.
1
0
2
Congratulations to #MusahLab PhD student Hamidreza Arzaghi @H_Arzaghi for his remarkable contributions to this work!.
1
0
3
Our newest publication is out in @naturemethods! It highlights the potential of biomaterials in realizing the translational power of organoids. #MusahLab.Full article:
5
58
346
RT @CarolynBertozzi: Applications welcome for the Stanford Science Fellows postdoctoral scholars program:. Science Fellows .
0
161
0
Congratulations to the #MusahLab team of graduate and undergraduate students for their remarkable collaborative efforts!.
0
0
0
Here's the related research article that inspired this work:
1
0
0