📣 Happy to share a preprint of our latest manuscript, available now in #bioRxiv. In this work we use #DNAbarcoding, #lineagetracing and #singlecell technologies to interrogate #plasticity and #cancerevolution in #neuroblastoma. We show that… 👇🧵.

I am moving to bsky: @alejandrapcelab.bsky.social.

RT @JuliaVorhauser: JOB ALERT!🚨 The @MansfeldLab is #hiring a Postdoc to characterise how protein oxidation regulates cell cycle proteins i….

It was a collaborative effort led by @PaedCancerEvol, @OMRueda, @JeanEAbraham722 & @CarlosC24501217.

@CaldasLab @CRUK_CI @MRC_BSU @Cambridge_Uni @ICR_London Big shout out to AMAZING Abby, a force of nature that drove this research forward despite many drawbacks. You are a super star! HUGE CONGRATULATIONS @Abigail_Shea1.

❤️ Thank you to the patients who donated to this research, our research institutes and funders. This research was conducted in @CaldasLab and @PaedCancerEvol at @CRUK_CI, @MRC_BSU, @Cambridge_Uni and @ICR_London.

🧵 (3/3).We then used the platform to study cancer evolution and showed:.💡permanent non-genetic phenotypic changes in response to Olaparib. 💡tumours undergo treatment-specific functional changes. Importantly, some of these changes affected responses to next-line treatments.

🧵 (2/3).We next tested PDX responses to alternative clinical trial arms and other relevant treatments. 💡These data suggest PDXs could be used as anticipatory tools. However, we also highlighted important considerations when using PDXs in this way.

We developed a co-clinical trial platform for treatment-naïve triple-negative breast cancer. In vivo PDXs and ex vivo PDTCs were treated in parallel with patients. 💡 PDXs accurately mirrored clinical drug responses of their matched patient.

🆕 Breast cancer PDX paper out in Cancer Research ‼️.Breast cancer PDXs can predict patient drug responses, and model phenotypic and functional cancer evolution. Full text available: 🧵Key findings: 👇.#cancerresearch #breastcancer #xenografts.

I sincerely appreciate the invitation and the warm welcome. It was an honour to learn about the remarkable research being conducted at your institute. Thank you for sharing such valuable insights.

RT @HRazaAliLab: 📆 Only one week left to apply to our exciting postdoc position, closing the 24th!.Please RT and share with your network: h….

Thank you, too, to the amazing @Cecilia Roux who was instrumental in developing this research idea (and who will also be instrumental in delivering its success).

THANK YOU #Littleprincesses. I am honoured to receive a New Ideas Grant from @LPTrustUK. I am grateful for their support and excited to contribute to advancements in paediatric cancer treatment. #ChildhoodCancer #ResearchForACure #ICR.

RT @AlicesArc: ANNUAL REPORT 2022/2023: Pleased to share a summary of our record-breaking year. To find out more access the link. https://t….

RT @Nature: Nature research paper: Symbolic recording of signalling and cis-regulatory element activity to DNA

RT @CRUKCamCentre: We’ve had a great afternoon of short talks at the #CBTCESummerSchool24. Thanks to Dr Alejandra Bruna @PaedCancerEvol @IC….

🔗 Apply now: . #PhD #ClinicalResearch #CancerResearch #HealthcareChoices.

🚀 Exciting Opportunity! 🚀. We're seeking passionate clinicians to join our Clinical PhD Fellowships at @PaedCancerEvol at the @ICR_London . Advance your career in cancer research, gain expertise, and make a significant impact. 🎓🔬.

RT @AlicesArc: Delighted to host an RMS strategy setting day. The purpose was to commence the process of defining UK RMS research prioritie….