John O'Brien Lab
@OBrien_lab
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Vision research, electrical synapse, and vision restoration lab at the University of Houston.
Houston, TX
Joined March 2020
This protocol paper is a nice companion to Stephan's whorl paper last fall in JBC. It's hard not to admire the beauty that comes from an intracellular trafficking defect.
Characterizing ER Retention Defects of PDZ Binding Deficient Cx36 Mutants Using Confocal Microscopy: Work by Stephan Tetenborg, Elizabeth Martinez-Soler, and @OBrien_lab at @UHouston. #reproducibility #lifesciences #cellbiology
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RT @igjc2024: Thank you Dr Stephan Tetenborg, great talk! ."Trafficking of Connexin36 (Cx36) in the early secretory pathway" .
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Congratulations @EShihabeddin from @NeuroMDAUTH on his really cool new paper on methods to knock down genes in #zebrafish retina using strategies accessible to all. Thanks @NatEyeInstitute for F31 support.
frontiersin.org
High throughput sequencing has generated an enormous amount of information about the genes expressed in various cell types and tissues throughout the body, a...
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Chris's paper makes use of a GCaMP-tagged Cx36 transgenic mouse that we developed. It expresses Cx36-GCaMP at electrical synapses in the retina, brain, and even the pancreas.
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Calcium regulates bidirectional plasticity of electrical synapses. Chris shows us that most electrical synapses experience transient calcium increases when puffed with glutamate, showing widespread potential for plasticity.
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See Chris Lee’s new paper examining calcium microdomains at #connexin 36 electrical synapses in the #retina.
eneuro.org
Synaptic plasticity is a fundamental feature of the CNS that controls the magnitude of signal transmission between communicating cells. Many electrical synapses exhibit substantial plasticity that...
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Experience New Orleans at #ARVO2023. You will know who has by the powdered sugar on their pants.
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Congratulations @LisaOstrin for winning the Michael Oberdorfer Award in Low Vision Research. #ARVO2023
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When the OBrien lab leadership goes on vacation and doesn’t answer email, we REALLY go on vacation. I FOUND this tooth. What a thrill!.
Big, beautiful Allosaurus tooth found by a member of our Dino Dig 2022 crew. An amazing find 🦖🎉. #dinosaur #dinosaurs
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Zebrafish postdoc in the O'Brien Lab! Apply here or contact me directly:.
neurojobs.sfn.org
Are you interested in electrical synapses? Love zebrafish? Come join the O’Brien lab to examine niche specialization of connexins in gap junctions i
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Woohoo! Congratulations @OBrien_lab grad student @EShihabeddin for a great score on your F31 application:.Impact score: 20.Percentile: 5.0.Great job!.
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Are you interested in #electricalsynapse? We are looking for a postdoc to work on #connexin niche specialization in #retina and brain using #zebrafish genetics in our new lab @UHouston. Vision scientist? Meet me at ARVO next week. Please RT.
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In 1999, the research team cost 49% of a modular R01; in 2013, 75%. In 2021, the same team cost 98%; there is no room for other costs. It is impossible to fund this smallest basic team with a modular R01. #RaiseTheModularLimit. 3/3.
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This graph shows 1) NIH year 0 postdoc salary, 2) cost of 1 year 0 and 1 year 3 postdoc with benefits at UT Houston rates, and 3) full team including a technician and some PI salary, both estimated at 2/3 the cost of an average postdoc. #RaiseTheModularLimit. 2/3.
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Modular @NIH grant budgeting simplifies the budget process and sets a funding level target. When established, a modular R01 could pay for a research project. That is no longer the case; the cost of doing research has doubled. #RaiseTheModularLimit. 1/3
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Great lab for electrical synapses!.
Hello, team #gapjunction! We’re looking for a postdoc to join @HaasLab. We use #patchclamp and opto to map #connexin-coupled networks and unlock the mysteries of the thalamus. Contact info in profile. Friends and fans, please RT.
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