Nik Thomas
@NikThomas5
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Scientist, molecular and cellular microbiologist, enjoyment of sports and life experiences. Everlasting learner and observer.
Halifax, Canada
Joined June 2016
Molecular and Cellular Biology at the University of Guelph is hiring THREE new tenure-track Assistant Professors! Join our world-class, multidisciplinary environment where you’ll collaborate with excellent people and contribute to groundbreaking research and education. ⬇️. .
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Only two weeks left for registration to Vibrio 2024! Deadline for abstract submission will also close on August 15th so upload yours soon. See you in Lima! The conference will be 🔥
Thrilled to announce the upcoming VIBRIO 2024 meeting in Lima Peru Oct 20-23,2024. Check out website for preliminary program. Registration will open soon. Please share! Big thanks to the @BWFUND for the generous support. Also, thanks to @UCF and @UTSA! https://t.co/ShPOLa5yBA
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We are recruiting!!! In collaboration with the Lady Davis Institute, we have just posted for a new Assistant Professor position (non-tenure track) in host-virus interactions. The full details are found and the link below: https://t.co/19VuxjEfBM
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Another next level development in Tn-seq approaches. Well done!
CRISPRi-Tn-Seq! Great collaboration with @tvanop
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In a tour de force, Oriana Robinson then discovered that HexR was essential for cell filamentation (elongation), a feature that is critical for Vibrio fitness in chitinaceous environments.
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We also found that the HexR gene regulator is essential to support efficient growth, biofilm formation and cell motility when chitin is the sole carbon source.
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OprD type porins usually import COOH compounds so this was somewhat unexpected. We confirmed the localization of this porin to the outer membrane and show its functionality in chitin mediated cell growth
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A single channel OprD-like outer membrane porin was found to be critical for the import chitooligosaccharides. This 'new' porin is structurally distinct from the well known ChiP trimeric porin found in all Vibrios!
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Tn-seq allowed us to take a deep genome wide dive into chitin growth fitness determinants. Along with validating known chitin associated genes, we found some really interesting new linkages
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Vibrio enthusiasts... -We found a 'new' Vibrio chitin import porin! -Also found a vital gene regulator of cell filamentation that supports environmental fitness New work by @LandonGetz and Oriana Robinson from the Thomas Lab @Dal_micro_immun
biorxiv.org
Vibrio species are marine prokaryotes that inhabit diverse ecological niches, colonizing abiotic and biotic surfaces. These bacteria are vital players in the global carbon cycle, assimilating...
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Honoured to receive this recognition from @DalhousieU for Excellence in Graduate Supervision. I’ve been very fortunate to have an outstanding cadre of scientists in my lab. It’s a mutually enriching experience!
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Glad to see this one out in JBC! Thanks to @SBrinsmade and @DADiMaggioJr for their help deciphering the mechanism of action of our antivirulent, @carlamaduta for the Lactobacillus work and @Superantigens for encouraging my crazy ideas. Check it out:
jbc.org
Menstrual toxic shock syndrome (mTSS) is a rare but severe disorder associated with the use of menstrual products such as high-absorbency tampons and is caused by Staphylococcus aureus strains that...
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The bureaucratic work academics need to do before they are free to actually do science for 5 minutes https://t.co/EneHnfoeT3
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@MicrobialOcean, Alastair Simpson and I are seeking a postdoc to work with us on metabolomics of a fascinating protist-bacterial symbiosis in the Anaeramoebae! https://t.co/lq27WtCrwJ
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If you've induced phages, you may have wondered if you can do the 'opposite' - block entry into lysogeny. You can, using protein synthesis inhibitors! Better still, this yields a potent synergy, functionally turning a temperate phage into a virulent one. https://t.co/nkLBhPL1XD
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Assistant Professor position in our department in "Cell Biology and Metabolism" is open now! Please come be our colleague!
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13 PhD positions available in a European consortium working on the biotechnological potential of Archaea! Please spread the word! #positions #PhDposition 1 position in my lab. Apply here until the 12th of May! https://t.co/gljllNlWjY
archaeaforbiotechnology.eu
Title of the project: Analysis if the biogenesis of the archaeal cell envelope and surface structures This particular PhD position is aimed to understand the biogenesis of the archaeal cell envelop…
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Excited to share our latest study uncovering gut microbes and microbial metabolites linked to cardiovascular health! We show that Oscillibacter is associated w/decreased cholesterol in human subjects & that these bacteria take up &metabolize cholesterol. https://t.co/WOCKfF1xHG
cell.com
The gut microbiomes and metabolomes of 1,429 participants from the Framingham Heart Study were comprehensively profiled toward the identification of associations between microbes, metabolites, and...
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Excellent work on T3SS transcriptional gene regulation in Vibrio parahaemolyticus by Matsuda and colleagues. ⬇️ northern blotting….old school technique features prominently!
journals.plos.org
Author summary Many bacterial transcription factors undergo autoregulation, a process by which transcription factors regulate their own transcription to amplify or reduce the output responses to a...
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