NR IMPACT
@NR_IMPACT
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A collaborative group for early- and mid-career faculty who study nuclear receptors. Advancing science and career development.
Joined December 2020
For #WomensHistoryMonth, @zmadak is honoring JES Associate Editor ( https://t.co/dKaoSxBDCr),
@Prof_Riggins, for her knowledge and mentorship. @womensday #IWD2023 #InternationalWomensDay
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For #WomensHistoryMonth, @emiliampinto is honoring @Katja_K_Vassi, who is serving on our Annual Meeting Steering Committee, Endocrine Cancers SIG, #JCEM Editorial Board, for her passion and dedication to adrenocortical disorders. @womensday #IWD2023 #InternationalWomensDay (1/2)
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For #WomensHistoryMonth, @mjsikora is celebrating both @Prof_Riggins and @zmadak for their years of colleagueship. He admires their selfless contributions of time, energy, and support for trainees and faculty. @womensday #IWD2023 #InternationalWomensDay
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So excited to share the newest #pollocklab manuscript in @EndoSocJournals - this was my first (mini)review and super exciting to write on advances in prodrugs of #estrogenreceptor alongside my undergraduate student Hannah.
academic.oup.com
Abstract. Due to the complexity of estrogen signaling mediated by estrogen receptors (ERs) in a variety of biological environments, there is great interest
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Fantastic job by @ZheqiL and others in the lab. Thanks @mjsikora @JCarrollLab for help. Maybe @NR_IMPACT can take this on for other receptors, other tumor types? In the meantime pls provide #feedback 🙏 #bcsm
Please RT: ER/E2/breast cancer. We are seeking #crowdsourced datasets and opinions. We curated 136 published datasets, processed with one pipeline and made a browser to visualize E2-induced expression and ER binding. Feel free to try it out https://t.co/lOpu0vpm8H 🧵
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Excited to share a new @biorxivpreprint from the lab! In this study, we show that RXRα ligands activate transcription of Nurr1-RXRα heterodimers through a mechanism distinct from classical pharmacological #nuclearreceptor activation. https://t.co/Fhu6MllEql 🧵 @NR_IMPACT
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What a cool story from @NR_IMPACT member Doug Kojetin and colleagues dissecting Nurr1-RXRα regulation. NMR, transcriptional control, small molecules...what more can you ask for 😁
Molecular basis of ligand-dependent Nurr1-RXRα activation https://t.co/5Q6T45r6ez
#NuclearReceptors #NMR #TR-FRET
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Estrogene is an outstanding new resource to query the current state of knowledge of the ER-alpha transcriptome and cistrome in breast cancer models - fair warning that you might lose a day looking for your favorite genes! We're intrigued by the idea of expanding this though...
Fantastic job by @ZheqiL and others in the lab. Thanks @mjsikora @JCarrollLab for help. Maybe @NR_IMPACT can take this on for other receptors, other tumor types? In the meantime pls provide #feedback 🙏 #bcsm
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Please consider applying for our Summer Undergraduate Research Experience in Toxicology at the University of Illinois. This program is designed for under-represented undergraduate students that are interested in Toxicology. Due date Feb 15, 2023. https://t.co/ukIIz4VekI
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Our next step towards a clinical-grade #CAMKK2 inhibitor. Team effort led by @dhdrewry. @Dr_CaMKkinase @MetSigLab @anwarmedc @Chenchu48450284 @AwadDom @donaldmcdonnell
#dark_kinases
#randomactofkinases SGC-CAMKK2-1: A chemical probe for CAMKK2 https://t.co/Uv3WUKOqqR
#sgcunc; @thesgconline; @dhdrewry
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See @LindseySTrevino discuss her experiences as a Latina in #endocrinology, and how important the support she received by peers in @TheEndoSociety's FLARE program has been to her career: https://t.co/SgPDUH6zLO
#HispanicHeritageMonth
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We're thrilled to have this group of outstanding nuclear receptor scientists join NR IMPACT! We look forward to supporting their career development, and to leveraging their unique expertise. Welcome! 7/7
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.@AyeshaShafi14 is at @USUhealthsci. The Shafi Lab is focused on defining mechanisms and biomarkers of therapeutic resistance in patients with advanced prostate cancer (PCa) with the goal to develop better treatment strategies. https://t.co/neIwijEg81 6/7
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.@DrGlitterbear is at @RutgersU. The Roepke Lab studies actions of hormones, diets, and endocrine disrupting compounds (EDC) on neurophysiological functions via the hypothalamus, including energy balance, thermoregulation, stress, and reproduction. https://t.co/ygtRKRlGPI 5/7
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.@cdokafor is at @penn_state. The Okafor Lab combines computational and experimental investigations to develop a fundamental understanding of how protein function, in particular of nuclear receptors, is regulated. https://t.co/QwMYJzT8kM 4/7
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.@DrFanning also hails from Chicago, @LoyolaChicago. The Fanning Lab designs & investigates small molecule nuclear receptor inhibitors to reprogram transcription, prevent metastasis, and shrink tumors. https://t.co/BIBJcw046z 3/7
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.@cordoba_chacon is PI of the @Cordoba_Lab at @thisisUIC. The lab focuses on PPARgamma in liver biology and the development of non-alcoholic fatty liver disease. https://t.co/G0yMgPKXM7 2/7
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NR IMPACT is thrilled to welcome 5 new members! These scientists increase IMPACT's collective expertise in metabolism, structural biology and ligand binding, neuropharmacology, and cancer biology. https://t.co/1IztRRICOD Without further ado... 🧵1/7
nrimpact.com
NR IMPACT is currently co-chaired by co-founders Drs. Becca Riggins and Matt Sikora, with Drs. Sean Fanning and Lindsey Treviño. Co-founder Dr. Zeynep Madak-Erdogan serves as an "emeritus" co-chair,...
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#HispanicHeritageMonth Featured Member | @LindseySTrevino an Outstanding Abstract Award winner, speaks on her experience as one of the few Latinas during her career, and the support she received from peers in FLARE ( https://t.co/i2joITTzCI):
endocrine.org
If you are a basic science or clinical research trainee in endocrinology, the Future Leaders Advancing Research in Endocrinology (FLARE) is for you.
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I was a guest on "The Scientist Speaks" podcast from @TheScientistLLC "What Comes Up Must Go Down: Maintaining Hormone Balance Through RNA Decay" https://t.co/r85a0PLxem Huge thanks to @NSpahich for the invite and fun chat about my lab's research here at @CUAnschutz @rnabioco
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