Yu Nie Lab
@NIEYUniverse
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The lab of Dr. Yu Nie study on heart regeneration and cardiomyocyte proliferation. PI at State Key Lab of CVD, Fuwai Hospital, Peking Union Medical College.
Fuwai Hospital, PUMC, Beijing
Joined October 2023
Online Now! Targeting lysozyme 2 in endocardium promotes rapid recovery by modulating remote injury signals https://t.co/sLyQLoP6tY
#stemcells
cell.com
Fan et al. discovered that local cardiac injury triggers aberrant lysozyme 2 (Lyz2) expression in remote zones. Lyz2 acts as a remote-injury-triggered regulator of lysosomal degradation in endocard...
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Our collaborative work with Prof. Hui Zhang and Academician Shengshou Hu has been published in Cell Stem Cell. Delighted to share this with you all! https://t.co/MWLRRJEztJ
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New paper out in J Mol Cell Cardiol! We show that MMP9 deficiency promotes endogenous cardiomyocyte proliferation by shifting metabolism toward glycolysis via ACOT1. A new link between ECM remodeling and cardiac regeneration. https://t.co/FtLBudDYrU
#HeartRegeneration
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The essence of heart regeneration is turning back the developmental clock! Congratulations to Dr. Liu Ning, Dr. Pei Jianqiu, Dr. Xie Yifan, and their co-authors on the publication of their paper in Science Advances！ https://t.co/6CyjpwS2tK
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So happy to see our Nezha cover for JMCC featured at ISHR2025 in Nara! Check out our article here: https://t.co/xZuoys93rX
@NIEYUniverse @Rongtian2 @JMCCardiology
#JMCC #ISHR2025
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New work in our April issue offers a detailed cardioFISH protocol for #cardiomyocyte nuclear ploidy assessment. Available open access: https://t.co/sWp0lgPmet
@monikagladka @k8weeks @vagnozzirj #cardiotwitter
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Attended the Southern Cardiovascular Annual Conference in Guangzhou, China, in March 2025 and took a group photo with my team. AI generated an anime version—which one do you prefer?
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💓 Researchers identified Foxk1 and Foxk2 as key regulators of #cardiomyocyte proliferation, whose expression declines during postnatal heart development. 📖 @NatureComms | https://t.co/OwUDDBqcHv
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Foxk1 & Foxk2: Dual boosters of cardiomyocyte proliferation & heart regeneration!🫀They drive cell cycle progression & enhance metabolic reprogramming. AAV9-based gene therapy restores heart function after injury. #HeartRegeneration #Cardiology
https://t.co/myAaprlGb3
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Foxk1 and Foxk2: A key switch for activating cardiomyocyte glycolysis, proliferation, and regeneration. Congratulations to Dr. Dongcheng Cai and Dr. Chungeng Liu on their research published in Nature Communications! https://t.co/myAaprlGb3
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Our study was selected as the cover story of JMCC. Nezha, the mythical hero in China, wields a boundless magical red ribbon, symbolizing a DNA double helix extracted from cardiomyocytes. He throws the golden ring named QianKun, representing the cardioFISH probe. @JMCCardiology
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Check out our cover article from 2022 in J Mol Cell Cardiol. featuring protocols for isolating mouse cardiomyocytes at various postnatal stages! #Cardiomyocyte #Cardiology
https://t.co/7JUxs83liU
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In the DAPI-stained background of cardiomyocyte nuclei, FISH signals shine like stars in the galaxy. Our CardioFISH methodology for detecting cardiomyocyte ploidy is now online in J Mol Cell Cardiol—explore and use it! #Cardiomyocyte @JMCCardiology
https://t.co/XKghRxZr0C
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Congratulations to Dr. Yao and Dr. Bai from our lab for their cardioFISH Protocol being published online in JMCC! 🎉A detailed guide for precise analysis of cardiomyocyte ploidy.@JMCCardiology @Dryaozh
https://t.co/pUhS8TlkVq
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On January 11, 2025, Nie Lab held its annual group meeting. New beginnings, new hopes—believing in our talented team！ Together, we will boldly push the boundaries of medical science!
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Using nuclear volume measurements to accurately assess cardiomyocyte ploidy @Dryaozh @NIEYUniverse #AHAJournals
ahajournals.org
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Our research group's website officially launched today! https://t.co/M9mS64Lk6u It embodies our team's passion for life and dedication to science, serving as a home for our unity, friendship! Special thanks to Zehao.@Dryaozh Welcome to Nie Lab!
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Our work adds a new dimension to cardiomyocyte phenotypic analysis by giving significance to the nuclear volume of cardiomyocytes. Congratulations to Zehao and Lina on their research being published in Circulation.@Dryaozh PS: The visualization of cardiomyocyte ploidy using AI.
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The Labor Day holiday is a great time to revise papers. In the evening, I took a walk as the streetlights came on, and the church near the laboratory was peaceful and elegant.
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