Nucleic Acids Chemical Biology Lab, IIT Bombay
@NACB_IITB
Followers
131
Following
6
Media
6
Statuses
19
Research group of Prof. Pradeepkumar P.I. at @IITBombay. We specialize in the synthesis, biophysical, cellular and molecular dynamics studies of nucleic acids.
Mumbai
Joined May 2022
This is a Research Associate position (equivalent to postdoc).
0
0
0
We are looking for two RAs having PhD degrees with good synthetic skills to do Nucleoside Chemistry for drug discovery projects. Prior experience in nucleoside Chemistry is preferred but not necessary. You may send your CV with research summary to pradeepkumar@iitb.ac.in.
1
4
8
Sruthi has successfully defended her Ph.D. thesis. Congratulations Dr. Sruthi Sudhakar.
0
1
9
Siddharam has successfully defended his Ph.D. thesis. Congratulations Dr. Siddharam Bagale!
0
3
14
JRF Position in Molecular Modeling Dynamics Studies of Nucleic Acid- Protein Complexes in our group at IIT Bombay.
0
3
6
Annyesha Biswas has successfully defended her Ph.D. thesis. Congratulations Dr. Annyesha!
2
1
39
RT @HoebartnerLab: #SAMURI is a new #ribozyme for RNA-catalyzed labeling of RNA. It uses a new cell-permeable SAM analogue and generates a….
0
24
0
Our new work in collaboration with the group of Prof. Kiran Kondabagil at IIT Bombay @KiranKondabagil .Human Translesion Synthesis Polymerases polκ and polη Perform Error-Free Replication across N2-dG Methyleugenol and Estragole DNA Adducts
0
6
21
Our group is looking for talented postdocs in the following areas:.1. Synthetic organic chemistry: preferably with experience in carbohydrate and nucleic acid chemistry.2. Molecular modeling and dynamics with experience in the modeling and MD of biomolecules.
2
19
28
Priyanka Deshmukh has successfully defended her Ph.D. thesis. Congratulations Dr. Priyanka!
0
5
13
Work carried out in collaboration with @SGSrivatsan1 Lab. Probing juxtaposed G-quadruplex and hairpin motifs using a responsive nucleoside probe: a unique scaffold for chemotherapy - now published in Chemical Science
pubs.rsc.org
Paucity of efficient probes and small molecule ligands that can distinguish different G-quadruplex (GQ) topologies poses challenges not only in understanding their basic structure but also in...
0
0
6
Our new paper published in @jbiolchem .A collaborative effort with Gagnon Lab and @DamhaLab .Binding to the conserved and stably folded guide RNA pseudoknot induce.
0
5
8
Satendra Kumar has successfully defended his doctoral thesis. Congratulations Dr. Satendra Kumar
2
7
16
Translesion Synthesis across the N2-Ethyl-deoxyguanosine Adduct by Human PrimPol
pubs.acs.org
Primase-DNA polymerase (PrimPol) is involved in reinitiating DNA synthesis at stalled replication forks. PrimPol also possesses DNA translesion (TLS) activity and bypasses several endogenous nonbulky...
0
2
6
Our work on G-quadruplex have been published in @BiochemistryACS .Targeting Parallel Topology of G-Quadruplex Structures by Indole- Fused Quindoline Scaffolds
pubs.acs.org
Preferential stabilization of G-quadruplex (G4) structures using small-molecule ligands has emerged as an effective approach to develop anticancer drugs. Herein, we report the synthesis of three...
0
9
15
Bisindolylmaleimide Ligands Stabilize c-MYC G-Quadruplex DNA Structure and Downregulate Gene Expression @BiochemistryACS .
pubs.acs.org
G-Quadruplex (G4) structures play a pivotal role in diverse biological functions, including essential processes, such as telomere maintenance and gene regulation. G4 structures formed in functional...
0
2
3
Stabilization and fluorescence light-up of G-quadruplex nucleic acids using indolyl-quinolinium based probes - now published in Physical Chemistry Chemical Physics
pubs.rsc.org
G-Quadruplexes (G4s) are four-stranded motifs formed by G-rich nucleic acid sequences. These structures harbor significant biological importance as they are involved in telomere maintenance, transc...
0
3
4
Nucleoside Analogues with a Seven-Membered Sugar Ring: Synthesis and Structural Compatibility in DNA–RNA Hybrids
pubs.acs.org
Herein we describe results on the pairing properties of synthetic DNA and RNA oligonucleotides that contain nucleotide analogues with a 7-membered sugar ring (oxepane nucleotides). Specifically, we...
0
2
1