Mummery Lab
@MummeryLab
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Cardiovascular development & disease | Stem Cell Biology | Cardiac Organoids | Organ-on-Chip | @GlobalLUMC| @RENEW_Global. Tweets by group members.
Leiden, The Netherlands
Joined August 2022
π¨Preprint alert! STRAIGHT-IN Dual allows the generation of homogenous genetically-modified hiPSCs βͺοΈ Done in 1 week with ~100% efficiency βͺοΈ Markerless and near-scarless approach performed in >10days in a single-well βͺοΈ Carrying not one but two (single-copy) payloads Seeπ§΅below!
So you want to engineer your hiPSCs, but targeting DNA payloads requires multiple slow, inefficient steps for each construct. What if we could accomplish multi-site integration seamlessly? π¨Introducing STRAIGHT-IN Dual! 𧡠(1/n) Link: https://t.co/4BKAf4Or90
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π¨We have updated our STRAIGHT-IN Dual preprint! π§΅with all the details in the comments (1/n) Link: https://t.co/X7r5V9TPfl
@GallowayLabMIT @nbwang22 @BenBlakeleyJ @annionna
biorxiv.org
Targeting DNA payloads into human (h)iPSCs involves multiple time-consuming, inefficient steps that must be repeated for each construct. Here, we present STRAIGHT-IN Dual, which enables simultaneous,...
So you want to engineer your hiPSCs, but targeting DNA payloads requires multiple slow, inefficient steps for each construct. What if we could accomplish multi-site integration seamlessly? π¨Introducing STRAIGHT-IN Dual! 𧡠(1/n) Link: https://t.co/4BKAf4Or90
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How do cells transit from fate to fate? Quietly. @MITChemE
Cells transit through a quiescent-like state to convert to neurons at high rates https://t.co/lEELGkDMAP
#biorxiv_sysbio
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New career goal unlocked: β
Attending the #SynBio24 conference with my twin brother @marcblanch94. Thanks @GallowayLabMIT @billerbeck_s @ProfTomEllis and Yasunori for the amazing program and opportunity to present my last preprint STRAIGHT-IN Dual β¬οΈ https://t.co/E1u0dh3Sq1
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renew.science
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What characteristics should an MPS have to be useful for modeling human phenotypes? In this review, we (mainly @dennisnahon & @MoerkensRenee) created a reference for quantifiable 'design' and 'emerging' MPS features to compare to real human settings. https://t.co/t6F0L0w1Bq
nature.com
Nature Biomedical Engineering - This Perspective discusses the need for standards that allow for comparisons of quantitative physiological features in microphysiological systems and humans.
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Super thrilled to be part of the reNEW #ARTxSCIENCE competition! Choose your favorite image (obviously mine π) showing some exciting new work happening with another postdoc and myself! https://t.co/9AI0LHyjWy
#LUMC @MummeryLab #cardioid #confocal #stemcell
#cardiac
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Extremely happy to see the protocol manuscript for the STRAIGHT-IN platform out online and featured as protocol of the week @NatureProtocols.
#FeaturedProtocol this week is for STRAIGHT-IN: a platform for rapidly generating panels of #geneticallymodified #humanpluripotentstemcell lines https://t.co/OVWmwL7ixG
@A_BlanchAsensio
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Join Professor Christine Mummery (@MummeryLab), #reNEW Leiden @LUMC_Leiden, for a panel discussion at #ISSCR2024 on 'Use of Standards for Stem Cells in Non-Clinical Research' on Fri 12 July, 1.30pm-3.00pm CEST in Hall G2, Level 2.
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Happy to see our work highlighted at The Scientist magazine. Targeted Gene Integration for High-Throughput Applications https://t.co/8SLSqX46ez
the-scientist.com
A new approach using two types of recombinases lets scientists insert larger DNA payloads into human pluripotent stem cells faster than ever before.Β
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Kicking off the last session of Day 1 #ISSCRCincy is @MummeryLab with a fantastic update on her work on hpsc-derived cardiovascular tissue to study disease. @ISSCR
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We are pushing stem cell research further than ever before. Meet Professor Christine Mummery. Her work focuses on understanding cardiovascular development and disease mechanisms.β All reNEW researchers are leaders within their field, with a strong track record of scientific
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Congratulations to postdoc Ben Johnson, from the Richard Davis and @MummeryLab at reNEW Leiden for receiving a prestigious Marie Curie fellowship. Ben will use the fellowship to develop a stem cell based model for myocardial infarctions. Read more: https://t.co/bgQf3np9H6
renew.science
Ben Johnson, postdoc in the lab of reNEW Leiden AI Richard Davis and PI Christine Mummery, has been awarded a Marie-Sklodowska-Curie fellowship.
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Delighted to welcome Albert Blanch Asensio @A_BlanchAsensio as a visiting student with our lab! Albert pioneered STRAIGHT-IN with Richard Davis and @MummeryLab. We're excited to build circuits in these landing pad iPSC lines! https://t.co/xbAd7hABnM
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π§ #MeetTheSpeaker! π¬ @MummeryLab @LUMC_Leiden explores the potential of #iPSCs in disease modeling. From mimicking patient mutations to screening for drugs, the goal is to create a population study for personalized medicine. https://t.co/fyPhnJm4Un
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Perlecan (HSPG2) promotes structural, contractile, and metabolic development of human cardiomyocytes
cell.com
Johnson etΒ al. demonstrate that perlecan, a proteoglycan found in the extracellular matrix, promotes hypertrophic growth and cardiomyocyte maturation. Perlecan haploinsufficiency leads to increased...
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Thrilled to be awarded the NWO-XS grant to generate an inducible heart attack stem cell model in a fantastic lab! β¦@MummeryLabβ© β¦@reNEW_Globalβ©
linkedin.com
π π¬π‘π¨π ππ¨ ππ‘π π‘πππ«π - ππ«ππ§π ππ¨π« π§ππ° π¬πππ¦ πππ₯π₯ πππ¬ππ π‘πππ«π ππππππ€ π¦π¨πππ₯ π₯ A patch of genetically modified cardiomyocytes that contain a 'kill...
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The true #vascular meets #cardiac: it's going to be an awesome conference! Looking forward to it. Mark your calendars!ποΈ #Cardiovascular
@UofT_LMP @bme_uoft @UHN_Research @TGHRI_UHN @vascularbiology
Join the new EMBO Workshop 'The new cardiobiology' and deepen your understanding of the causes and early development of cardiovascular disease.π« π©Β Submit abstract by 28 November β‘οΈΒ https://t.co/HtQZnCV7m6
#EMBOCardioBiology
#EMBOCardioBiology Scientific organisers are:
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πInteresting insights on #organoids for drug discovery and personalised #medicine with Giulio Pompilio β@CCMonzino, Christine β@MummeryLab @lumc_leiden , Alice β@soragnilab (@uofcalifornia ) and β@BeumerJoep (@ihb_research )
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Yesterday took place the 14th DSSCR (Dutch Society for Stem Cell Research) meeting where I had the pleasure to present again the STRAIGHT-IN platform. I would like to thank the organizers for the opportunity and for the best presentation award. @MummeryLab
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