MikulaLab
@MikulaLab
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Research group @tu_wien focusing on bioorthogonal chemistry, (bio)molecular tools, drug targeting and theranostics 🧪💨🛠💊🧬🔬
Vienna, Austria
Joined July 2017
…and it was all yellow 🎶🙃 Many thanks again to the entire team, this time especially to co-author Barbara for the amazing design 💪 Big THX also to @angew_chem for selecting our cover picture! Stay tuned for the next level of bioorthogonal bond-cleavage 😉#bioorthogonal
#OnTheCover Transforming Aryl-Tetrazines into Bioorthogonal Scissors for Systematic Cleavage of trans-Cyclooctenes (Hannes Mikula and co-workers) https://t.co/pWkFyA1lbt
@MikulaLab @tu_wien • https://t.co/m5WcyGkqRT
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https://t.co/0VGP4ZeO9X To continue the story of hydroxyaryl-tetrazines: sulfonation significantly accelerates release and enables further modification! Shout-out to our collaborators @IOCBPrague Milan Vrabel & team! Many THX & congrats again 🥳 @Patrick__Keppel #bioorthogonal
onlinelibrary.wiley.com
A new generation of sulfo-tetrazines for cellular click-to-release activations is described. These derivatives are easily accessible, stable, and achieve complete release of TCO-caged molecules...
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YELLOW Tetrazines finally published 🙃🟨✂️ Congrats and big THX to the entire team, especially @pg12_wilko, Walter Kuba & @Patrick__Keppel 💪 We keep pushing bioorthogonal bond-cleavage to the next level 📈 More to come soon 😉 Stay tuned! #click-to-release #bioorthogonal
Transforming Aryl-Tetrazines into Bioorthogonal Scissors for Systematic Cleavage of trans-Cyclooctenes (Hannes Mikula and co-workers) @MikulaLab @tu_wien #openaccess
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Transforming Aryl-Tetrazines into Bioorthogonal Scissors for Systematic Cleavage of trans-Cyclooctenes (Hannes Mikula and co-workers) @MikulaLab @tu_wien #openaccess
onlinelibrary.wiley.com
Highly reactive aryl-tetrazines are widely used for fast bioorthogonal ligation. However, their application in click-to-release chemistry has been impeded by significantly limited release efficienc...
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Incredibly delighted and grateful that our paper in Monatshefte für Chemie - Chemical Monthly has been selected for the Best Paper Award 2024 by Springer! 🤩🧪🥳 Thanks @AT_ChemSociety @springer and @Click_Chemist @MikulaLab 💪🏼 Check out the paper: https://t.co/YUxKGfmhuu
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Post-doc position in beautiful Vienna! 👩🔬 👨🔬 Are you a motivated PhD graduate with experience in peptide chemistry, structural biology, or biochemistry? 👨🎓 👩🎓 Find out more about our research projects, team, and opportunities at TU Wien! https://t.co/NxUhamI3xr
@chemistry_tuw
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In the fourth month of the year, we have our fourth ACIE publication out - check out those colourful fluorophores!
onlinelibrary.wiley.com
We report here the discovery of a powerful novel fluorophore class with an imidazo[1,2-a]pyridinium core, termed PyrAtes. The synthesis was achieved in a single step, demonstrating a wide array of...
Neue Moleküle fluoreszieren in allen Regenbogenfarben! 🌈 Ein Team um @MaulideLab, @theo_chem & Harald Sitte von der @MedUni_Wien, hat eine Reihe neuartiger fluoreszierender Moleküle entwickelt. Warum diese in der Medizin & Pharmazie unverzichtbar sind ⤵ https://t.co/R7yPnClSul
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Super excited to see that our paper on 2-pyridyl tetrazine reactivity reached 10000 views in under 2 years!🔥 Amazing to see the impact of this work. #ResearchMilestone @MikulaLab @pg12_wilko
pubs.acs.org
The tetrazine/trans-cyclooctene ligation stands out from the bioorthogonal toolbox due to its exceptional reaction kinetics, enabling multiple molecular technologies in vitro and in living systems....
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I am honored and grateful to receive the diploma thesis award "GÖCH Förderungspreis" of the Austrian Chemical Society. Many thanks to my supervisor @MikulaLab as well as @AT_ChemSociety! I am ready and excited for the journey ahead! #research #PhD #bioorthogonal rules 😎🥳
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Our latest research on radiolabeled tetrazines is now OA in Monatshefte für Chemie, part of a special issue honoring Fritz Sauter, my academic grandfather. @pg12_wilko @MikulaLab @SpringerNature
https://t.co/Znckk4NZVl
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Re puzzle: The final piece of 1 of the 8 problems was created by @FinkChemistry (THX!). If you want to take on this challenge, here it is :) All you need to know: the result is a number as part of coordinates. A "scientific mindset" helps😉Don't spoil! Results only! #chemtwitter
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Re puzzle: The final piece of 1 of the 8 problems was created by @FinkChemistry (THX!). If you want to take on this challenge, here it is :) All you need to know: the result is a number as part of coordinates. A "scientific mindset" helps😉Don't spoil! Results only! #chemtwitter
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Two weeks ago I finally picked up the best birthday present ever :) Hardly anyone will know, but at least a few will understand why this "blue roll" means so much to me 😎MANY thanks to my family for the amazing puzzle that led me to the coordinates of one of my favorite places!
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Amazing three days together with @MikulaLab, @BrigitteHolzer1 and @birgitm16 enjoying the sun and especially the fascinating talks at @ELRIG_UK therapeutic OLIGOS & ECBS2023 @EuChemS at the beautiful Site of @AstraZeneca Gothenburg. Thanks for having us!
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It’s been a pleasure to have you here! Many thanks for visiting us and sharing your amazing research! Enjoy your time in Vienna and the symposium! Thanks to your talk I know at least one more friend of Ubiquitin: DMSO 😉 All the best!
Great visit to TU Wien today. Thank you @AnneConibear @MikulaLab Marion Goldeck and Brigitte Holzer for hosting. Looking forward to the Ubiquitin and Friends Symposium tomorrow! #Ubiquitin
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#OnTheCover Substituent Effects in Bioorthogonal Diels-Alder Reactions of 1,2,4,5-Tetrazines (Dennis Svatunek and co-workers) https://t.co/9OHeMgilHA
@Click_Chemist @MikulaLab @tuvienna
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Excited that our work on tetrazine reactivity is featured as a cover picture. Great artwork by first author Nici highlighting the importance of asynchronicity. Read the open access article here: https://t.co/kqkyQOgx5W
@MikulaLab #clickchemistry #compchem @ChemEurJ
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Substituent effects in bioorthogonal Diels-Alder reactions of 1,2,4,5-tetrazines (Svatunek et al. @Click_Chemist @MikulaLab @tuvienna) #OpenAccess
https://t.co/9OHeMgilHA
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📢📢Last day to apply for our PhD position & Postdoc position📢📢 please RT. Thanks!
olallalab.org
“Everything we want is outside of our comfort zone” Our multicultural lab are fully committed to foster equity, diversity and inclusion in science. We have a strong team spirit, which is expected...
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Many thanks to @florianaigner & @tuw_media for the interview and this article (German only)
KLICK! Der Chemiker Hannes Mikula forscht an Molekülen, die wie Legosteine ineinanderklicken https://t.co/VHSIGSWGXm
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