Menendez Lab
@Menendez_Lab
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Great group of people working on developmental cancer, stem cell biology and immunotherapy group at @CarrerasIJC pursuing to cure pediatric leukemia.
Hospital Clínic, Barcelona
Joined April 2020
Great news 🎉 OneChain will lead a €3M+ consortium with @VHIO to develop a dual #CART therapy against #glioblastoma, one of the most aggressive brain cancers. The goal: complete preclinical development and move closer to clinical studies!
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What a great day at ReALLnet get together! Thanks to the Fundacion Uno entre Cienmil foe hosting us. Thanks Pablo Velasco for leading us
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Surprising finding that standard chemo treatment induces resistance to menin inhibitors in AML. Published in @ISEHSociety journal Exp. Hem:
exphem.org
Inhibitors of the menin-KMT2A interaction are promising agents for the treatment of KMT2A-rearranged leukemias. We evaluated menin inhibition in patient-derived xenografts of KMT2A-rearranged...
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We are hiring a Molecular/Biochemist scientist for a unique journey in advancing research and therapeutics in pediatric leukemia. Vision shared by Barcelona Children's Hospital Sant Joan de Déu (@SJDbarcelona_es) and Josep Carreras Leukaemia Research Institute (@CarrerasIJC ).
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Wow!!!! Our best friends ever 😍
We are so happy to share that our latest paper is finally out in @NatImmunol! 🤩 There’s a lot of work and passion behind this discovery of the preTCR as a novel #immunotherapy target for T-cell acute lymphoblastic #leukemia (T-ALL). 🔬🩸 https://t.co/ueNfwH5oPp
@Nature
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It has been an immense pleasure and growth opportunity for our lab to learn from @MaribelParraLAB on HDAC inhibition in infant 4;11 proB ALL! Thanks team and congrats!!
🙏Of course, we want to thank all our collaborators for their engagement and continuous suport to the project @CarrerasIJC @Menendez_Lab @clarabueno_74 🧡Also thanks to agencies who have funded the project in the last years @AgEInves @SaludISCIII @fcarreras @ContraCancerEs
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The photo fails to capture real credit. Give credit where credit is due! This work has been possible thanks to those who led it: Nestor Tirado, @k_fidyt, many members of @Menendez_Lab and @onechaintx and @ToribioLab and many many other colleagues nationwide. Thanks to all!
🧬 New research from @Menendez_Lab presents a novel CAR-T cells therapy designed to target 2⃣ specific markers of T-ALL: the CD1a and CCR9 proteins. Preclinical results show high efficacy and safety in the lab, paving the way for clinical development in the short term. 🔗
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Pleased to share our last comprehensive review on CAR T cells with a particular focus in AML. Great leadership of @InesZugasti and members of @hospitalclinic @Menendez_Lab
https://t.co/bpHSmmT0C0
nature.com
Signal Transduction and Targeted Therapy - CAR-T cell therapy for cancer: current challenges and future directions
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Thrilled to see our latest study published! 🚀 We present a novel dual immunotherapy approach for T-ALL. Huge thanks to the amazing team @Menendez_Lab and all collaborators who made this possible, @ToribioLab @onechaintx and others! 🔗
link.springer.com
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy characterized by high rates of induction failure and relapse, and effective targeted immunotherapies are lacking. Despite...
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You rock Alex!! Great leadership @vaquerolab ! Thanks for alliwing us to be part of this journey
Thrilled to share that we have been awarded a project CaixaResearch Health Call 2025 @CaixaResearch @CaixaResearchCA involving @CarrerasIJC @idis_research @fcarreras with 4 outstanding groups @vaquerolab , Dominguez Lab, @Menendez_Lab & Ribera Lab Excited to get started!!
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EHA 2025 research award for @LabOrfao. Mentor of some of us, friend of many of us a great collaborator of the lab. Lucky us to have experienced UNIQUE Salamanca exposure and training. Congrats Jefe!!!!
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#EHA2025 lifetime achievement award to Jesús San Miguel; my boss, mentor, friend, wedding planner and second-father! 18 years ago I was blessed by start working under his leadership, and I'm looking forward to the next 18 years! #mmsm
@ClinicaNavarra @CIMA_unav @sehh_es @_pethema
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¡Enhorabuena a Marisa Toribio, nombrada miembro de la Academia Europaea! Se une a los otros nueve Académicos del CBM: Ricardo Amils, Jesús Ávila, Luis Blanco, Paola Bovolenta, Esteban Domingo, Antonio García Bellido, Crisanto Gutiérrez, María Llorens y Encarnación Martínez Salas.
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It's such a great honor to be part of this team! Happy that our effort is being valued by @FundAladina and @FundacionFero ! We will keep working for the fight against paediatric cancer! 👩🏼🔬👩🏼🔬👩🏼🔬 @Menendez_Lab @clarabueno_74
Ganador de la I Beca FERO - Aladina en cáncer pediátrico Felicidades Dr. @Menendez_Lab
@FundAladina @CarrerasIJC #cancerpediatrico #becasFERO
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Gracias @FundacionFero y @FundAladina x apoyar a nuestro equipo @cpaniselloPhD @clarabueno_74 a llevar este trabajo a clinica
Ganador de la I Beca FERO - Aladina en cáncer pediátrico Felicidades Dr. @Menendez_Lab
@FundAladina @CarrerasIJC #cancerpediatrico #becasFERO
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We thank @ACIR_org for highlighting our paper, 'CD22 CAR-T cells secreting CD19 T-cell engagers for improved control of B-cell acute lymphoblastic leukaemia progression' published in @jitcancer, co-authored by @jarroyo8 @H12Octubre @CNIOStopCancer & @aidafc8 @CarrerasIJC
To minimize tumor antigen loss and reduce the risk of CD19+ leukemia progression in r/r B-ALL, Arroyo-Ródenas and Falgas et al. developed dual-targeted CD22 CAR T cells secreting an anti-CD19 T cell-engaging antibody (CAR-STAb-T). https://t.co/fHZiwciiIE @Alvarez_Vallina
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Un pas més a prop de la producció fiable de #cèl·lulesmare sanguínies per a la medicina regenerativa Estudi a @BloodJournal de @HMar_research amb @CarrerasIJC
@BigSpinLab @ASH_hematology @Menendez_Lab @clarabueno_74 @iCERCA @CienciaGob @recercauniscat
https://t.co/h4r07M8VaY
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Lab representation there 😀 @clarabueno_74
Dos días intensos de ciencia, innovación y colaboración en el FERO Scientific Retreat 2025, organizados con la colaboración de @AstraZenecaES y Altos Labs, en las magníficas instalaciones de @EDEMempresarios , Valencia.
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Happy to share our latest work @Menendez_Lab @clarabueno_74 @aidafc8 @CarrerasIJC in collaboration with the @Alvarez_Vallina Lab at @CNIOStopCancer and @H12Octubre on new CD22 and CD19 T cell redirecting strategies spanning CAR &T-cell engagers (STabs). https://t.co/QozE7pDBzZ
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