Mariel Kozberg
@MarielKozberg
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Vascular neurologist | Neuroscientist @MassGeneral
Joined January 2021
Cortical superficial siderosis – cortical iron deposition in #CerebralAmyloidAngiopathy – is associated with chronic neuroinflammation. A potential contributor to future hemorrhage #ICH risk? Congrats to @CorinneAAuger on her first author publication! https://t.co/dQb9EVr7PV
jneuroinflammation.biomedcentral.com
Background Cortical superficial siderosis (cSS) has recently emerged as one of the most important predictors of symptomatic intracerebral hemorrhage and is a risk factor for post-stroke dementia in...
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Using multi-modal imaging, Kozberg et al. report that loss of vasomotion occurs early in cerebral amyloid angiopathy in a mouse model. This loss coincided with initial vascular amyloid-β deposition and preceded the occurrence of microbleeds. Read at https://t.co/xljnepCErD
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Honored to share the 2025 Ralph L. Sacco Scholarships for Brain Health have been awarded to two outstanding researchers: Drs. Hortense Triniac & @KatyWala, whose work will contribute to advancing research in brain health. @American_Heart @AANmember
https://t.co/AHlxvKV7ZQ
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The Kozberg Lab is so proud of @KatyWala for receiving this scholarship to study #APOE, #CAA, and #BrainHealth!
Congratulations to our 2025 recipients of the Sacco Scholars Program: Katy Walsh, Ph.D., and Hortense Triniac, Ph.D.! 🎉 These scholarships provide two early career trainees with funding for two-year research programs that focus on #BrainHealth. https://t.co/PzjeK03M5u
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Novel study ties lower CSF Aβ42 to CAA severity through CAA-related macrohemorrhages and enlarged perivascular spaces, advancing biomarker-driven approaches. #AHAJournals @AltenBaris @MarielKozberg @guroledip @SMGreenbergNeur @MGHNeurology @BWHNeurology
https://t.co/gIKKlHJv0U
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Dami Adetunla presents our mouse model of cortical superficial siderosis at ISC! #CerebralAmyloidAngiopathy
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This advisory discusses amyloid-related imaging abnormalities in ppl receiving antibodies directed at the amyloid-beta peptide for treatment of early-stage Alzheimer’s & safety issues related to treatment ✍🏼 @hugoapariciomd @HinmanLabUCLA @MarielKozberg @SMGreenbergNeur @msgoyal
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Is neuroinflammation central to vascular damage in #CerebralAmyloidAngiopathy? Could neuroinflammation be a treatment target for #CAA? Really enjoyed writing this review with Hilde van den Brink, @SabineV159, and @Ellis_van_Etten! https://t.co/7smZS6OP4c
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Day 2: Kicking off with an insightful morning session tackling complex clinical dilemmas at the intersection of: - CAA and Hypertension 🫀 (@marco_pasi85) - AFib and CAA 🩸 (@a_charidimou) - Anti-amyloid treatments and ARIA ⚡️(@MarielKozberg) #CAAConference2024
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Looking for a post-doc interested in neuroimaging/neurophysiology in disorders of consciousness, who wants to join our @RECOVER_program to understand, predict and promote consciousness recovery. Please contact for more info, and spread the word to any who might be interested!🧠⚡️
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Looking forward to catching up with friends @SfNtweets! I am also looking for a postdoc trained in neurophys/systems neuro who is interested in modeling brain genetic mosaicism in neuronal cultures/mouse and combine with voltage imaging. Happy to meet at SFN to discuss! Plz RT.
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Kozberg Lab at MGH Neuroscience Day! Very proud of our team!
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How does vascular dysfunction progress in #CAA? See our pre-print which used a combo of in-vivo two-photon microscopy and MRI to track changes in #vasomotion, #pulsatility, #CBF, #CVR, and more!
biorxiv.org
Background Cerebral amyloid angiopathy (CAA) is a cerebral small vessel disease in which amyloid-β accumulates in vessel walls. CAA is a leading cause of symptomatic lobar intracerebral hemorrhage...
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📢📢 Our dynamic team is looking for a fellow who will engage in stroke-related clinical trials and lead research projects on the interaction between CSVD and AD-pathology 🧠. If you are passionate 🤩, an MD, and interested, contact me!
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How will anti-amyloid immunotherapies and ARIA affect stroke care? @phil_bilodeau, John Dickson, and I review the latest data on ARIA in the context of acute stroke care and secondary stroke prevention here:
mdpi.com
Anti-amyloid immunotherapies have recently emerged as treatments for Alzheimer’s disease. While these therapies have demonstrated efficacy in clearing amyloid-β and slowing cognitive decline, they...
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#ischemicstroke prevention after ICH requires shared decision making & careful risk benefit assessment! @MarielKozberg & I review the current literature. @UConnNeurology @MGHNeurology @EricaSchuyler @ajaytunguturi @karantarasaria @mjaffa_do @Takanshooka
https://t.co/mfuGW6XfnZ
link.springer.com
Current Treatment Options in Cardiovascular Medicine - Survivors of intracerebral hemorrhage (ICH) are not only at risk for recurrent ICH but often also have vascular risk factors which predispose...
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For all interested: Our proposed pathophysiologic framework for understanding CAA (and maybe other small vessel diseases?)
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#TopicalReview: "Role of Inflammatory Processes in Hemorrhagic #Stroke" by Drs. Ohashi, DeLong, Kozberg, @dmazurhart, @SusanneVanVeluw, Alkayed & @LaurenHSansing #AHAJournals
https://t.co/jbl8uVwS2M
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