NazareGroup
@GroupNazare
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Medicinal Chemistry Research @LeibnizFMP Berlin
Berlin
Joined May 2022
PI3Ks are validated therapeutic targets but the lack of isoform-selective inhibitors limits our understanding of their complex physiological roles. Check out our review in @TrendsinPharma on recent progress to tackle this challenge! https://t.co/k69T9jWIMm
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Very inspiring and productive meeting with @AlgulLab at TUM. What a warmly welcome. We are glad that we finally meet face to face after working together for more than a year! Thanks for having us and for the fruitful discussions. We are excited about our collaboration.
Wonderful meeting/discussions with our friends from twitterless Marc Nazare and his team in Berlin @LeibnizFMP. Thanks to @dfg_public great joint effort and progress on generation of new class SHP2 inhibitors. @AlgulLab learnt a lot about medicinal chemistry. 👌
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An exciting Factor Xa lead optimization journey meets #MD simulations. Check out the experimental and computational studies on rescaffolding, single-site modifications and non-classical bioisosters by @HanSun_Lab @sanofiDE and us in #JMedChem:
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Our publication on CISCM in collaboration with the @SelbachLab and KNMFi @KITKarlsruhe is now published in @ChemMedChem! CISCM allows for unbiased drug target identification based on photoimmobilization of compound libraries and quantitative affinity-purification MS.
Looking for a method to identify drug targets? Our new paper on drug target identification by quantitative proteomics is now online:
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Great collaboration with the @VolkerHaucke-lab on PI3KC2α inhibitors. We are happy to present this work now in nature chemical biology. Open access at:
nature.com
Nature Chemical Biology - Compound library screening combined with medicinal chemistry and structural biology approaches enables the development of potent and highly selective cell-permeable...
Team around @VolkerHaucke and @GroupNazare identified a potent inhibitor of lipid kinase PI3KC2α activity, that serves as a lead for further drug development Read more 👇 https://t.co/eQepyT0W3e
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Our probe for the detection of CB2 receptors in native cells and zebrafish is out now in @ChemicalScience! Great collaboration with @CarreiraGroup @mariovdstelt @DVeprintsev @gertschgroup @BroichhagenJ @NIH @Roche Artwork by @BarthvanRossum #chemscicovers
https://t.co/iPVPCuU1Je
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