Fiedlerlab
@FiedlerLab
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Twitter account of the Fiedler group. (student handled)
Berlin, Germany
Joined August 2020
We would also like to thank all the people involved in this study. @MRuwolt @theliulab @JeremyAMMorgan.
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To substantiate our findings, we collaborated with @PhosphorusFive @CEStieger and @daniel_roderer @FelixSchoepf to obtain mass spectrometry spectra and the first-ever Cryo-EM structure of pyro-and oligo- phosphorylated proteins.
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Our research revealed that the metastasis suppressor protein NME1, previously identified as pyrophosphorylated by Morgan et al. 2024, contains an oligophosphorylated amino acid residue in mammalian cell lines.
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During our investigation of protein pyrophosphorylation, we identified a novel post-translational modification (PTM), which we have termed 'Protein Oligophosphorylation'.
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On the way to understanding the role of pyrophosphorylation, he also discovered a new mode of protein pyrophosphorylation! Thank you Arif for the hard work!.
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Follow up to our discovery of endogenous protein pyrophosphorylation, Arif Celik, a PhD student from our lab, decided to select one of the newly found „pyrophosohoproteins“ and see what effect does this PTM have on protein activity.
pubs.acs.org
While the function of protein phosphorylation in eukaryotic cell signaling is well established, the role of a closely related modification, protein pyrophosphorylation, is just starting to surface. A...
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Together with the paper checkout this „News&Views“ article about the „Pyrophosphomania“!.
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Happy to share our latest paper on protein pyrophosphorylation - yes, it exists! It has been a long journey with many wonderful co-workers and collaborators. Thank you all!.@JeremyAMMorgan @MRuwolt .
nature.com
Nature Chemical Biology - A tailored proteomics workflow to identify endogenous protein pyrophosphorylation in human cells was developed, revealing the dependence of the modification on inositol...
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RT @LeibnizFMP: 📢Vortrag: Wer quasselt da? Wie Zellkommunikation funktioniert, Prof. Dr. Dorothea Fiedler @FiedlerLab .Für Lehrkräfte, Sch….
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After a lot of efforts from our former post doc Sarah Hostachy, we are do happy to see this out!.
Fluorination Influences the Bioisostery of Myo-Inositol Pyrophosphate Analogs (Dorothea Fiedler and co-workers) @FiedlerLab @LeibnizFMP
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Unexpected results often lead to fascinating discoveries!.Have a look at this new paper from our lab where @timaguirre_chem developed an inhibitor for IP6Ks and found out some really cool mechanistic details about the inhibition.
elifesciences.org
A subtle mutation in the ATP-binding site of inositol hexakisphosphate kinases increases their conformational flexibility and thereby makes them susceptible to isozyme-selective, allosteric inhibit...
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After the amazing bike ride and an even better scientific session, it was barbecue time :)
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The group retreat begins with a ~ 40 km bike ride thru a beautiful forest! 🚵♀️🚵🚵♂️
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RT @LeibnizFMP: 📢Exciting talk alert! Maja Köhn @MAJAFL @UniFreiburg will delve into "Function, selectivity & chemical targeting of protein….
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RT @GabrielSchaaf: Congratulations to Minh Nguyen Trung @FiedlerLab for a wonderful defense of his PhD "Elucidation of Inositol Polyphospha….
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Congratulations Minh for successfully defending your PhD! A very well deserved “summa cum laude” and thank you so much for contributing towards unveiling of the black box of inositol polyphosphate metabolism :)
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RT @ISMSC2023: Dorothea Fielder @FiedlerLab is up here next at #ISMSC2023 with a really interesting talk on inostol pyrophosphates and thei….
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