Mark_Davies_Lab
@MDaviesLab
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Applied pathogen genomics laboratory at the Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Australia
Joined May 2019
Collaboration is the key! @TheDohertyInst @UniMelbMDHS @MenziesResearch @MonashHealth @WestSydHealth.
Excited to share our latest research published in @LancetMicrobe exploring epidemiology and lineage dynamics of invasive S. pyogenes across diverse regions of Australia. A huge collaboration with many partners @syctong @MDaviesLab @rh_chisholm. 🧵👇.
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Please read the next S. pyogenes genomic epi instalment from the laboratory (thread below). Huge amount of work by 'Dr Dr' @ouli_xie. Many thanks to the multitude of collaborators who contributed to this important work.
Excited to share our latest research published in @LancetMicrobe exploring epidemiology and lineage dynamics of invasive S. pyogenes across diverse regions of Australia. A huge collaboration with many partners @syctong @MDaviesLab @rh_chisholm. 🧵👇.
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This study highlights the value of systematic investigations of publicly available (and high quality) bacterial genome sequences. The ability to direct future phenotypic investigations lies on developing tools and approaches to identify evolutionary cues hiding within genomes.
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Excited to share our new lab work - driven by our fantastic PhD student (now Dr) @magnus_gj with @HayesScience @syctong: Cataloging of chromosomal inversions in #StrepA reference genomes. Sets an analytical framework for investigations in other pathogens.
academic.oup.com
Abstract. Chromosomal inversions are a phenomenon in many bacterial species, often across the axis of replication. Inversions have been shown to alter gene
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Special thanks to Dr Aneley Getahun Strobel @HayesScience @wytamma @BenjaminHowden @MulhollandKim @DickStrugnell1 and many others - especially the hospital/public health workers in Fiji @MOHFiji @TheDohertyInst @UniMelbMDHS @MCRI_for_kids with support including @gatesfoundation.
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Pleased to share our latest collaborative research on the genomic epi of typhoid fever in Fiji published in @MicrobioSoc. Wonderful collaboration with public heath parters in Fiji/Aus. Evidence of 'selection' in the S. Typhi Vi capsule locus.
microbiologyresearch.org
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Honoured to be a member of the StrepA Outbreak Prevention Team @eurekaprizes 2024. Huge thanks to the many students and staff that facilitate the magic of team work and collaboration. Congrats to all #EurekaPrizes finalists!.
🏆 Huge congrats to @MDaviesLab from @TheDohertyInst who, together w/ collaborators at @IMBatUQ, won the prestigious #EurekaPrize for their crucial work on tracking Strep A spread and advancing vaccine development. [Watch . @UniMelbMDHS @UniMelb @TheRMH.
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Out now: @magnus_gj latest PhD work: Systematic evaluation of existing #StrepA transposon mutagenesis work using a pan-genome framework. Interactive html is included for searching of your favour strepA gene: @HayesScience @syctong.
zenodo.org
This is the raw output files of analyses using methods within the Transit toolkit on Streptococcus pyogenes transposons sequencing datasets. In total there are nine datasets of both Tn5-like and...
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With an ageing population, we should be wary of the clinical burden of pathogens such as SDSE. Timely review led by the talented @ouli_xie. More clinical information on SDSE disease is needed (watch this space. ).
Is Streptococcus dysgalactiae subp. equisimilis (SDSE) just the poor cousin of S. pyogenes? Although it mostly causes disease in adults, there's actually much clinical and genomic overlap! See our review just out in CMR @syctong @MDaviesLab @TheDohertyInst
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We have a research position in 'Microbial Bioinformatics' available in our laboratory. Masters/PhD level applicants with bacterial genomics experience are encouraged to apply. Come and join us @TheDohertyInst @UniMelbMDHS! Applications close 17 June 2024
jobs.unimelb.edu.au
Careers at The University of Melbourne
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RT @TheDohertyInst: World-first research shows Streptococcus pyogenes (#StrepA) & emerging pathogen Streptococcus dysgalactiae subsp. equis….
doherty.edu.au
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Excited to see our latest collaboration in print. Fantastic analysis driven by the talented @ouli_xie . Much still to learn about #strepA and #SDSE transmission and associated clinical genomic epidemiology. @TheDohertyInst @UniMelbMDHS
Great to share our latest paper in @NatureComms examining real-world transmission interactions between S. pyogenes and the emerging pathogen S. dysgalactiae subp. equisimilis (SDSE) @syctong @MDaviesLab @TheDohertyInst + many collaborators!.🧵👇
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New global genomic framework for SDSE from our team at the @TheDohertyInst @UniMelb and @DrDaveMacca @usceduau with many international partners. Big shout out analytical skills of @ouli_xie. Refer to thread 👇for key messages. More SDSE news coming soon!.
nature.com
Nature Communications - Streptococcus dysgalactiae subsp. equisimilis (SDSE) is an emerging cause of human infection closely related to Streptococcus pyogenes. Here the authors investigate the...
Excited to share our Streptococcus dysgalactiae subsp. equisimilis (group C/G strep, SDSE) population genomics study highlighting its overlap with S. pyogenes (group A strep). Made possible by many partners @MDaviesLab @syctong @DrDaveMacca @TheDohertyInst
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RT @N_van_sorge: A great and inspiring 1.5 day visit to Doherty Institute and MCRI in Melbourne kindly hosted by Mark Davies and @JoshOsowi….
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Huge effort by a huge consortia! Amazing resource for the global community.
Awesome🇦🇺team science @natcomms . Spearheaded by André Mu @muandre01 and anchored by Mark Walker @UQ_News, paper applies a standardized genomic, transcriptomic, proteomic + metabolomic tech framework to leading sepsis pathogens -> now open source for all!.
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Timely review in @NatureRevMicro by our national team on the latest research developments in #StrepA pathogenesis, host responses, genomic epidemiology, AMR and vaccine development. Including @magnus_gj @mark_uq @UQ_News @TheDohertyInst @UniMelbMDHS
Our team's latest work published in @NatureRevMicro. Here we cover the most recent advances and developments in Group A Streptococcal research.. Well done Stephan Brouwer, @tania_riv_her @MDaviesLab & team! #GroupAStrep.
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Link to @magnus_gj @Miranda_E_Pitt blog on direct bacterial RNA-seq on the ONT platform. Great work!.
Happy to share this little behind-the-paper of out recent @NatureComms paper on the identification of the #StrepA M1UK sub-lineage in Australia, and more excitingly we found that a single nucleotide change increased SpeA production!.
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@AmyVJennison @BenjaminHowden @mark_uq @HayesScience @DrmartinaS @syctong @lachlanjmc Media release available here (thanks @TheDohertyInst comms team).
With cases of scarlet fever on the rise in Aus, researchers from @TheDohertyInst & @IMBatUQ are staying ahead of the curve using genomic surveillance to track the spread of bacterium Group A #Streptococcus .@MDaviesLab @UniMelbMDHS @TheRMH @UQ_News.
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This work is not possible without active collaboration between academic, clinical and public health laboratories in Australia. @AmyVJennison @BenjaminHowden @mark_uq @HayesScience @DrmartinaS @syctong @lachlanjmc Stephan Brouwer, Nadia Keller and many more!.
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We also detect evidence of convergent evolution with the presence of new toxin repertoire in Australian M1uk sub-lineages. We've previously associated this toxin repertoire with scarlet fever associated #StrepA clones in East Asia and Australia.
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