Luke Jelen
@LukeJelen
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Clinical Lecturer in Psychiatry | Brain imaging. Ketamine. Glutamate.
London, England
Joined February 2011
Our BMJ editorial → Non-prescribed ketamine use is rising in the UK: More awareness, research, and treatments are needed @guerrini_irene, @KalkNicola, and Professor Sir John Strang.
The number of people starting treatment for ketamine addiction in 2023-2024 reached 3609 in the UK, more than eight times higher than in 2014-2015. The rise in non-prescribed ketamine use in recent years is a cause for concern, say doctors.
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RT @ed_chesney: 🌿🚨Hot paper alert🚨🌿. Should we be prescribing cannabis to treat acute psychosis?? I actually think it might be a good idea….
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RT @TCleare: Published today in Lancet Psychiatry, after 7 years of hard labour. the first long-term head-to-head comparison of two augme….
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RT @psybalazs: I want to highlight a finding from ( that IMO did not receive enough attention in #psychedelic trial….
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RT @cathy__davies: 🚨PhD Studentship Available!🚨 Join our lovely team @KingsIoPPN & a super cool project using 7T MRI to investigate glutama….
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The only real psychedelics are tryptamines, lysergamides, and phenethylamines. Ketamine is not a psychedelic. Cannabis is not a psychedelic. MDMA is not a psychedelic. Do you agree or disagree?.
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Huge thanks to superstar supervisors- Professors Mitul Mehta @mehta_mitul72, Allan Young and James Stone @drjmstone, generous funding from the @The_MRC, support from @KingsCRF, @NIHRMaudsleyBRC, @kclcfad and @KingsIoPPN. With special thanks to our courageous study participants.
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Thrilled to have passed my PhD- investigating glutamate and opioid mechanisms of antidepressant response to #ketamine. Honoured to have been examined by Professors Catherine Harmer and Alan Schatzberg. Thank you for your insights and such a stimulating discussion!
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Great work @TheBorisLab and team! More on Ketamine +/- Naltrexone mechanisms (in humans) soon(ish) 👀.
In 2018, we (w @NolanRyWilliams) found that an opioid antagonist, naltrexone, blocks #ketamine's antidepressant effect. Is ketamine an opioid? What else does naltrexone do? We took these Qs into mice to get some answers, with @mCherryGarcia and many more
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We have recently treated two cases of treatment refractory mania, that after decades of quality life lost due to inadequate pharmacological treatment both demonstrated profound response to ECT. We are writing up to support the view ECT should be used sooner rather than later.
ECT definitely my 1st choice if I had severe depression:.1)By far most effective treatment.2)Quickest/most dramatic response.3)Safer than meds.4)Loss of personal memories time limited. All psych & med treatments have benefits/risks- ECT among those with best ratio. Learn more:.
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RT @TCleare: We are recruiting to a new 2 year research post in mood disorders - details here!
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**Unintentional Ketamine overdose via Telehealth**. 1.2g (20.6mg/kg) dose prescribed sublingually but taken orally. US ketamine prescribers- how common is to prescribe such a dose?! Far and above the max we would regularly prescribe in the UK.
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RT @cathy__davies: 📢 Super excited to have a project available in the 2024 @NIHRMaudsleyBRC PhD studentships, using 7T MRI to investigate g….
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The endogenous opioid system in the medial prefrontal cortex mediates ketamine’s antidepressant-like actions
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A true hero ❤️! Congrats to Charles Bowman.
Congratulations to Charles Bowman for recognition and nomination of the Education Hero Award. Thank you for your ongoing support to deliver the MRCPsych Course to our Core Trainees 🏆👏.#medicaleducation #SouthLondonEducationProviders #MTP #CoreTrainees
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RT @N_R_Livingston: Happy New Year and Happy New Preprint! 🎉Excited to share the 2nd paper from my PhD - looking at the effects of the GABA….
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