Annabelle Singer
@DrACSinger
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Neuroscientist & Neuroengineer at Georgia Tech and Emory. Learning, memory, and memory impairment in disease, oh my. Views may be mine, may be borrowed.
Joined September 2020
RT @SfNtweets: Help spotlight the innovative research, exceptional mentorship, or outstanding education initiatives of a colleague, mentor,….
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Our research, funded by the @NIH, was featured on FOX 5! Thanks to interviewer Kevyn Stewart for sharing how Nuri Jeong's grandmother inspired her research, recently published in @Nature. Get a glimpse into the lab here:
fox5atlanta.com
Researchers at Georgia Tech have uncovered findings with implications for understanding memory and learning, which could lead to restoring memory in Alzheimer's patients.
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RT @gt_neuro: Our next #InterfaceNeuroGT session highlighted cutting-edge techniques for measuring and manipulating sensorimotor and cognit….
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This study reveals that chronic 40 Hz flicker enhances hippocampal activity that is essential for memory encoding and retrieval. This work also demonstrates a new way to evaluate brain stimulation for Alzheimer’s disease, by assessing its effects on memory processes.
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We found 40 Hz flicker increases CA3-CA1 coordination during navigation. CA3-CA1 interactions play a central role in representing future experiences.
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Using recordings of 1000s of neurons during virtual reality navigation and Bayesian decoding, Abby discovered that 40 Hz flicker enhances representations of future positions, or prospective coding. These representations of future position coincide with efficient navigation.
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Despite recent work on how 40 Hz sensory stimulation, or “flicker” affects disease models and human patients, it’s unknown how flicker impacts neural correlates of memory.
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Check out our paper out today in PNAS: “40 Hz sensory stimulation enhances CA3-CA1 coordination and prospective coding during navigation in a mouse model of Alzheimer’s disease”. Led by Abigail Paulson with Lu Zhang and @AshleyMPrichard
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The paper in Nature Magazine is here: This work was a team effort with heavy lifts by Abigail Paulson and Stephanie Prince.
lnkd.in
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Get the back story behind Nuri Jeong and Xiao Zheng's recent paper in @Nature, here:
bme.gatech.edu
Inspired by Georgia Tech researchers' personal experiences with Alzheimer's, a recent study published in @Nature shows how inhibition isn't just about stopping activity but precisely timing it to enhance learning.
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This paper is a testament to Nuri’s perseverance and all the great advice she got along the way including from @GStanleyNeuro, Sam Sober, Joe Manns, @vulcnethologist, and more.
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In contrast to a support role, inhibitory cells are proactive players in memory formation by selecting relevant information for memory processing.
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Probing deeper, this inhibitory gating is vital to neural mechanisms of spatial memory: reactivation of excitatory cells’ neural patterns that represent paths to a goal.
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Nuri and Xiao found that inhibitory interneurons are central to swiftly learning important places. We discovered that interneurons act as gatekeepers that open specifically on paths to important locations and enable learning for those places.
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