Mariele Lensink
@LensinkMariele
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Genetics and Genomics Graduate Student at UC Davis. Quantitative and evolutionary genetics enthusiast, amateur SLiMulator, friend of dogs.
UC Davis
Joined December 2020
https://t.co/q2O4t3PzU9 new paper out! Somatic mutation and selection during plant development 🌱
biorxiv.org
Plants accumulate germline mutations through meristematic lineages where somatic purifying selection could remove deleterious coding mutations and produce perceived mutation biases, like lower genic...
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Happy Halloween! Here’s something a little spooky for your timeline for my fellow slurm HPC cluster folks.
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New in #GENETICS: @LensinkMariele, @Grey_Monroe, @SpicyBotrytis identify an important role of trans-acting loci for transcriptomic plasticity in response to salicylic acid, thereby describing plant adaptation mechanisms to environmental changes. https://t.co/QxuyxcWxuR
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Looking up at your SNPs towering over the bonferroni line. (He’s impressed with the significance, but wondering if you accounted for population structure)🔍🤔🧬
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Some special memories from the Cinque Terre this past week before the Gordon Research Conference for Quantitative Genetics. Looking forward to sharing my work and learning from some great scientists!
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Trans-regulatory loci shape natural variation of gene expression plasticity in Arabidopsis https://t.co/7kidmsNrC1
#biorxiv_genetic
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My Facebook memories from the 2010’s really keep me humble.
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Philo-statisti-mathematical question - In (e)QTL mapping, how do you actually compare the effect of a cis-eQTL with a 90% effect size on one transcript to a trans-eQTL with a 4% effect size on 20% of the transcripts in the transcriptome? (use any effect size descriptor you like)
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Is my adrenaline rush from looking at cool genomic data, or is it the Celsius™ I'm downing at 9 pm? A mystery we'll never solve.
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"Sorry I was late for dinner, I got stuck in a local minimum"
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Never ending fetch requests. Paw up is his doggy sign language for please Yes he learned it - he’s very smart, he is employed full time at UC Davis getting his dog-torate degree. (Sorry)
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Today is @C_Caseys using one pathogen as a lens to understand how plant defense evolves across species. I mean what sounds easier than measuring ~100 pathogen isolates virulence across ~100 plant genotypes from 8 different species
biorxiv.org
Diverse qualitative and quantitative genetic architectures can successfully influence fungal virulence and host range. To model the quantitative genetic architecture of a generalist pathogen with an...
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That one theoretical biologist at the conference doing modeling shit no one understands
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A couple of great lab talk/poster combos at #icar2024 this year. Starts with @LensinkMariele (co-advised with @Grey_Monroe) talking about mutation rate heterogeneity and evolution Tuesday in session C12. For bonus info, stop by poster and ask about trans plasticity work.
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Then Thursday at 4:58 is @AAR_plantbio in session C-37. If you have ever wondered how a single gene evolves across 60+ species in the Brassicaceae with rampant gene loss, duplication, functional chgs and other orthology/paralogy be damned shifts. This is for you. #icar2024
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My dog will be applying to grad school in the fall he is interested in maize please let me know if you have any lab openings thank you 🐶🔎🌽
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Lucky to be part of such a great team. New lab photos from resident photographer and PhD student Kehan Zhao💚
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