Ryan Langlois
@LangloisLab
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Associate Professor of Microbiology and Immunology Lab interested in viral immunology, viral evolution, and virus host interactions
Minneapolis, MN
Joined April 2015
RT @sofianmoraes: My 1st first-author manuscript is out in @eLife! This project started back in 2019 with the question “what makes a viral….
elifesciences.org
The birth of the antiviral gene APOBEC3B in ancient primates is linked to the evolution of a potent counterdefense by herpesviruses, a host-pathogen interaction maintained to present day.
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. @ShanleyRoach is the winner of the @umncbs 3 minute thesis competition!!! Super proud. She is also on the postdoc market!
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RT @anice_lowen: The Lowen Lab is recruiting post-docs! Join us at Emory University, Atlanta, to do exciting fundamental virology on influe….
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RT @TheMenacheryLab: It’s been 987 days since the last #bingo with @LangloisLab. And while I usually don’t do bingo when I’m off campus, I….
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RT @vaughandy: Excited to share that our paper on injury-induced lung tuft cells is out now in @eLife! This is the fruit of an awesome coll….
elifesciences.org
Influenza-induced pulmonary tuft cells are a heterogenous population and emerge independently of Type 2 and interferon signaling, and do not impact dysplastic epithelial regeneration.
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We also provide some suggestions for standardization/ways to cross compare these powerful new models. All of these models have huge strengths and I am excited to see where they go next! 3/3.
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We discuss how viruses (and other microbes) from several exciting models (wild mice, dirty mice, rewilded mice, wildlings etc) impact homeostasis, disease, and subsequent infections. 2/3.
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Thrilled to share a new review article from our lab and @JessicaFiegePhD in @MicrobioSoc JGV on the impacts of eliminating natural mouse virus from traditional lab mouse experiments: 1/3.
www.microbiologyresearch.org
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RT @YountLabOSU: Our new paper in Science Advances led by Adam Kenney showing that direct infection of cardiomyocytes by influenza virus dr….
www.science.org
Direct heart infection, not systemic inflammation, drives influenza virus–associated cardiac pathology in IFITM3 KO mice.
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RT @keirballa: I'm looking for RAs & scientists to help launch my lab @czbiohub! We discover and deploy zebrafish viruses to capture infect….
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This work was supported by @JessicaFiegePhD and @AFranOfScience and a wonderful collaboration with @Hunter_lab and @TaliaWiggen . @ShanleyRoach fell in love with tuft cells during this project and will likely have some great pics to show!.5/5.
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Interestingly, while the baseline microbiome was different between wt and tuft cell KO mice flu infection drove similar changes increasing Proteobacteria. These data show how influenza impacts the microbiome independent of tuft cells or starting community composition 4/5.
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This resulted in increased ILC2s in the GI tract, dependent on infection and the presence of tuft cells. While absence of tuft cells did not alter morbidity, we think this dynamic represents an unappreciated mechanism driving inflammation at a site distal to the infection 3/5.
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Similar to other groups we did not observe significant numbers of tuft cells in the lower respiratory tract during acute infection but did see them appear post virus clearance. Surprisingly though we found an increase in tuft cells in the GI tract during flu infection! 2/5.
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Delighted to share a new story led by @ShanleyRoach out now in @JVirology We sought to evaluate the role of tuft cells during acute influenza infection. There were lots of fun surprises along the way. 1/5.
journals.asm.org
Influenza A virus (IAV) is a respiratory infection in humans that can lead to a wide range of symptoms and disease severity. Respiratory infection can cause systemic inflammation and damage in the...
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RT @CBLopezLab: The Keystone Meetings Respiratory Viruses:New Frontiers and Viral Immunity: Basic Mechanisms and Therapeutic Applications a….
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RT @JExpMed: Cohousing of dirty pet store mice infected with a multitude of pathogens leads to transmission of these agents to clean labora….
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RT @JExpMed: Playing dirty with virus transmission. @ChristinHerrma1 and @CadwellLab highlight study ( by @lizfay20….
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RT @JExpMed: Herrmann @ChristinHerrma1 and Cadwell @CadwellLab highlight study by @lizfay20 et al. ( that investiga….
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