Mark Moehle Lab
@LabMoehle
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Assistant Professor @UF_Pharmacology/@UFCTRND. Defining synapses & circuits altered in CNS disorders. Opinions are my own. Former @WCNDD_TN @DukeWestLab/@uabsom
Joined July 2021
Join us on Dec. 2 for a webinar on the major advances in basal ganglia mapping, including cross-species cellular mapping and open-access visualization tools. 📅 Dec. 2, 9-10:30am PT 📍 Online 🔗 Register: https://t.co/G7CpRr18pw
#studyBRAIN #BICAN
alleninstitute.org
Neuroscience webinars from the Allen Institute to hear about latest cell types researchers from various scientists.
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Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! https://t.co/J5HekY1Pc0
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My department is hiring! Come join a cutting-edge and collaborative environment. Details below:
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Happy Postdoc Appreciation Week.
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Wooooo!! Congrats to Jessi from this prestigous award from @SfNtweets Check out her cool work from the lab at SFN in San Diego!
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The Neuroscience Dept at American University is hiring for a tenure-track position at the Assistant level and with expertise in Computational Neuroscience. Apply by Sep 15: https://t.co/Jnrwvr7GBP
#FacultyJobs #AcademicJob #Neuroscience #CompNeuro #AI #ComputationalPsychiatry
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Proud of all three trainees from the lab for winning awards for their posters and talks!!
180+ neuroscientists & trainees from across US & abroad discussed latest research in Alzheimer’s, Parkinson’s, ALS, dementia @UF-hosted International Research Conference on Neurodegenerative Diseases July 9-12, co-sponsored by the MBI. Learn more: https://t.co/nLr0kzylho
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Researchers funded by the NIH will be required to make their scientific papers available to read for free as soon as they are published https://t.co/K704HXnyoD
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Proud to be a part of the @TylersHope think tank on dystonia today! Rick and Emily at the foundation did an outstanding job with the @FixelInstitute team to bring together an incredible team of clinicians and scientists to find the cure
2025 Dystonia Think Tank. Energized for moving the needle after a lively, passionate collaboration of top scientists
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Applications are now open for the Shenoy Undergraduate Research Fellowship in Neuroscience (SURFiN) program for the 2025–26 academic year. The SURFiN program aims to spark and sustain interest in neuroscience among undergraduate students who have not had access to research
simonsfoundation.org
The Simons Foundation is accepting applications from undergraduate students for its Shenoy Undergraduate Research Fellowship in Neuroscience program.
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Very excited to share BlueBerry, our publicly available, multichannel wireless optogenetic device for freely moving rodents! Visit https://t.co/HlL4X6sVRW for documentation, and see our preprint for details: https://t.co/v0BpnEWtkg
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#PhF25 awardee Dr. Erick Rodriguez-Palma @UF_Pharmacology is evaluating a novel compound for the treatment of #fibromyalgia. He will study whether it reduces pain behaviors in male & female mice with fibromyalgia induced by chronic restraint stress. https://t.co/4hEQDktyWj
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🔬 @LabMoehle studies the circuitry and behaviors behind symptoms of movement disorders like Parkinson’s and dystonia at @UF. With @NIH support, translating #UFMedResearch into novel therapies advances treatment for these diseases and drives discovery worldwide.
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It's really out now!
Pathological α-Synuclein Perturbs Nuclear Integrity https://t.co/8auK7JLSR9
#biorxiv_neursci
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This work would not have been possible without funding from @NIH @NIH_NINDS, the Harry T Mangurian Foundation, @UFMBI and the incredible environment @UFMedResearch @UF_Pharmacology and @fi
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Taken together, this work shows that aggregation of synuclein causes physical damage to the nuclear membrane, which results in nuclear dysfunction, and that this is a toxic gain of function of pathological synuclein.
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This altered nuclear morphology is associated with functional deficits in the nucleus including mislocalized RNA, altered nuclear envelope repair, and increased sensitivity to environmental toxins.
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In both mouse and human patients, these nuclear and peri nuclear aggregates alter neuronal morphology, and fracture the inner most layer of the nuclear membrane, the nuclear lamina.
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We show that synuclein aggregates in cortical neurons form impressive ultrastructures around the nucleus in the PFF model of synucleinopathies. These are very similar to patients with LBD.
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New @LabMoehle preprint from rockstar grad student (and looking for a job) Michael Millett! Synuclein in the nucleus has remained controversial for multiple reasons. Here we use super resolution and expansion microscopy to help answer this controversy https://t.co/nE3TsYBrKn
biorxiv.org
Pathological aggregates of α-synuclein are a hallmark of a group of neurodegenerative disorders collectively termed synucleinopathies. The physiological function of α-synuclein and the detrimental...
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