Interested in how your body shape is associated with #ColorectalCancer? Read our work published in @ScienceAdvances! 🧵🥳 @IARCWHO @ECSA_IARC 1/9.

RT @IARCWHO: New #IARCpaper identifies environmental & genetic predictors of #adiposity gain in midlife. Suggests environmental factors - e….

RT @HFreisling: 📢spoiler alert: In #midlife, the environment rather than genetic predisposition driving #Obesity 👉. 👏@LPeruchet @DimouNiki….

Are you on the beach and you’ve just finished your book? 🏖️📚I have good news! 🤩.Our new article on adiposity and inflammatory biomarkers is out in @BMCMedicine 👇🏼.Specially thanks to @GonzalezGilEM for this great collab👩🏼‍🔬👩🏻‍🔬.

Enjoyed presenting and the great discussion on Body Shape Phenotypes at the Mendelian randomization conference! 🥳👏🏻#mrconf24

RT @IARCWHO: We are participating in the #FêtesConsulaires!.Visit our stand to test your knowledge on #CancerPrevention & receive a special….

RT @HFreisling: 😊Very proud that our study was featured on by Lauryn Higgins, a two times Pulitzer Price winner. Ku….

RT @IARCWHO: IARC's Dr Heinz Freisling @HFreisling, co-author of this recent study on body shape & ↗️ #ColorectalCancer risk, offers insigh….

RT @ScienceMagazine: People with one of two body shapes are at a higher risk of #ColorectalCancer, finds new research. .

RT @ScienceAdvances: People with one of two body shapes are at a higher risk of #ColorectalCancer, finds new research. .

RT @IARCWHO: New study in Science Advances has found that having an overall obese body shape or a tall, centrally obese body shape increase….

Finally, I would really like to thank @HFreisling, @RCarrerasTorres, @DimouNiki, @AnjaSedlmeier and all the people involved in this work for their endless support and guidance! 9/9.

This suggests distinct putative causal pathways between adiposity subtypes and colorectal cancer! 🤯 8/9.

We also found that the associations between the generally obese and the tall, centrally obese body shapes and colorectal cancer were driven by brain and adipose tissue-specific genetic instruments, respectively. 7/9.

And this is not the end! The generally obese body shape was associated with gene expression patterns in tissues with high proportion of neural cells, whereas the tall, centrally obese body shape was associated with gene expression patterns in mesenchymal cells.🧐 6/9

After a GWAS on these body shape phenotypes we identified thousands of genetic variants associated with them with nearly no genetic overlap suggesting different genetic architectures among body shapes. 😳 5/9.

Ok, but… Laia, can you tell us more about these body shape phenotypes? OF COURSE! 👇🏼🕵🏼‍♀️.4/9.

We found that a generally obese (PC1) and a tall, centrally obese (PC3) body shape were both positively associated with colorectal cancer in observational and Mendelian randomization analyses! #TriangulationIsKey 3/9

#ColorectalCancer is considered an obesity-related cancer but are adiposity subtypes differentially associated with it? We have used multi-trait body shape phenotypes based on BMI, height, weight, waist-to-hip ratio, and waist and hip circumferences to answer this question.🤓 2/9.

RT @HFreisling: 📢 Think body shape not (just) #BMI .#obesity subtypes & #ColorectalCancer just out in @ScienceAdvances.👏 @LPeruchet @AnjaS….