The Koirala Lab
@KoiralaLab
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RNA is a tremendously important yet mysterious biomolecule with diverse functions. Our lab at UMBC aims to dig deeper into the RNA structures and functions!
Joined April 2022
The last day of our first graduate student (@KrishnaNaba, in dark blue) in the lab! Best wishes for your new career at NCI. We will miss you!
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At the 2025 UMBC Summer Undergraduate Research Fest (SURF), students presented and celebrated their summer's worth of research and applied learning experiences while contributing to UMBC's scholarly community. Three participants share their moments of joy throughout the process.
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Undergraduate Magdalen Ruth presenting her research in UMBC’s SURF symposium! Koirala lab is proud of you, Magdalen! Way to go! Many thanks to her graduate student mentor Hasan @hbnnbd #umbc @UMBCChemistry @KoiralaLab #RNA
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I am thrilled to share that our latest research article focusing on the structural plasticity of HIV-1 RRE has been published . I would like to thank my supervisor, co-authors and collaborators. @KoiralaLab
https://t.co/8tUdDnzvzj
academic.oup.com
Abstract. The Rev response element (RRE) forms an oligomeric complex with the viral protein Rev to facilitate the nuclear export of intron-retaining viral
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Our lab in UMBC news! Awesome story about graduate-undergraduate collaboration and mentorship! UMBC’s Koirala Lab celebrates students’ award-winning RNA research and peer mentorship
umbc.edu
A talented trio of students has earned accolades for their innovative work with Deepak Koirala, assistant professor of chemistry and biochemistry. Their awards are replicating like the RNA they...
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New paper alert! Congratulations to Manju Ojha et al. We have shown how structural plasticity of RRE modulates nuclear export of HIV -1 RNAs. Mutation-driven RRE stem-loop II conformational change induces HIV-1 nuclear export dysfunction
academic.oup.com
Abstract. The Rev response element (RRE) forms an oligomeric complex with the viral protein Rev to facilitate the nuclear export of intron-retaining viral
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haven't posted in a while but happy to share the news I've received the Beckman Young Investigator award 🥳 grateful for the hard work of my team pushing the barriers of understanding #Rloop biology and for this recognition🧬
Meet Charles Bou-Nader, PhD, 2025 Beckman Young Investigator Awardee from @emorymedicine! Read more about this news from Beckman Foundation: https://t.co/377U60x29g
#BYI
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It was very rewarding meeting at RNA Society Meeting #RNA25 @RNASociety. Our awesome graduate student Hasan Banna @hbnnbd gave an amazing talk about new RNA imaging tools. Meeting colleagues, students, postdocs and some non-RNA (proteins) friends as well was a great experience!
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A great day of RNA Society Meeting 2025 at San Diego #RNA @RNASociety! Our graduate student Naba Krishna Das @KrishnaNaba presenting his research to expert audiences #UMBC @UMBCChemistry!
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It's fascinating to see that so many people are obsessed with that one biomolecule! #RNA25
@RNASociety
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It’s time to change the title from tenure-track assistant professor to tenured associate professor! Thanks to students, mentors, family, colleagues and friends for their help and support. I am inspired and motivated to serve the science more than ever!
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Congrats to @KrishnaNaba for defending his doctoral thesis and being the first one from the @KoiralaLab !
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The first PhD from The Koirala Lab!! Congratulations Dr. Naba Krishna Das! The lab is proud of you and your accomplishments. Wish you all the best for future endeavors!
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How to find fantastic new #RNAs? The J2 antibody is the gold standard to detect, map & enrich dsRNAs. Co-led by @CharlesBNader, Kevin Juma, Ankur Bothra & Steve Leppla’s lab, we visualize how J2 recognizes dsRNA and define its epitope, specificity & bias. https://t.co/ELXCvLv4ap.
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I am honored and deeply grateful to the College of Natural and Mathematical Sciences, @UMBC for selecting me as the recipient of the Robert F. Steiner Award for Outstanding Biochemistry Graduate Student in the Department of Chemistry. @KoiralaLab
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What a rewarding day for the Koirala Lab today! Graduate student, Manju Ojha, gave an excellent talk at FCBIS, and received outstanding biochemistry research award from CNMS at UMBC. Two undergraduates, Megan and Jason, received outstanding research awards! Congratulations!!
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If you want to unfold the same molecule through multiple directions, DNA nanoswitch caliper is the way to go!
New preprint on single-molecule mechanostructural fingerprinting! https://t.co/AhoHsJAylg We use DNA nanoswitch calipers to characterize the geometry and mechanical stability of telomeric DNA G-quadruplexes. #Biophysics #SingleMolecule #Mechanobiology #DNAnanotech
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Our #RNA multimer paper out now in @nature! #cryoEM of 2 distinct nanocages GOLLD and ROOL and membrane-associated OLE. Multimers at ultra-low concentrations, special covariance for cross-molecule kissing loops, and speculation on function https://t.co/ZihCKHIIcX. 1/2
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Are RNA 3D models accurate enough to be biologically useful? #CASP16 experimentalists say: not so much. https://t.co/rUlFyDaiUJ Thanks for leading this paper @rachaelkretsch @AKryshtafovych! 1/2
biorxiv.org
Accurate biomolecular structure prediction enables the prediction of mutational effects, the speculation of function based on predicted structural homology, the analysis of ligand binding modes,...
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Our talented undergraduate, Megan, presenting her research at UMBC’s Undergraduate Research and Creative Achievement Day (URCAD)! Lab is proud of you, Megan! #UMBC @UMBCChemistry #RNA @KoiralaLab
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