Klevit Lab
@KlevitLab
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@UWBiochemistry. Ubiquitin and small heat-shock proteins. Biochemistry and biophysics. Student-run account. Email Rachel with inquiries.
Seattle, WA
Joined August 2021
Please RT. Join the Kleviteers! Exciting post-doctoral opportunities available now. Uncover the mysteries of small heat shock proteins. Do a deep dive into protein ubiquitylation. Check us out at
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RT @WXZhaoLab: Really happy to share our paper out today @ Molecular Cell, where we elucidate the pivotal roles of BRCA1-BARD1 ligase in no….
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Grad School Updates: Natalie Stone pursues a PhD at University of Washington -.#gradschool #research
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The final version of our work highlighting the role of BARD1 in BRCA1/BARD1-mediated chromatin recognition and modification is out now @embojournal.
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RT @ElyseFischer7: I'm a bit behind on posting this (as I just finished moving transatlantic) but my second PhD paper is finally published!….
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RT @Structure_CP: The Preview ‘HHARI in motion reveals an unexpected substrate recognition site for RBR ligases’ from Ben Stieglitz @QMUL….
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RT @millerlab: Super excited for Chris Woods to defend his dissertation (working with @KlevitLab) gonna be 🔥🔥.
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A wonderful collaborative effort with the labs of Mike Guttman, Trisha Davis, and Mike MacCoss.
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HDX-MS, XL-MS, and NMR studies reveal that HHARI is released from auto-inhibition by a phosphomimetic mutation, and that the Rcat domain contains a substrate-binding surface.
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We sought to uncover how HHARI is activated through a non-CRL dependent mechanism and how it recognizes its target protein, 4EHP.
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We are thrilled to share our work on Cullin-independent substrate recognition by the RBR E3 ligase HHARI, led by @KHReiter now out in @Structure_CP. While RBRs share a conserved catalytic module, substrate recruitment mechanisms remain enigmatic.
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RT @castel_pau: There is a story that I have been wanting to tell for a while regarding a scientific journey that started more than 6 years….
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RT @jnpruneda: Really excited (and a little jealous) that @tylergfranklin is spending the week up in the @KlevitLab at @UWBiochemistry. Can….
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RT @jnpruneda: I’m very excited to share our latest work, in which we identify, characterize, and apply a Legionella deubiquitinase that ta….
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Exciting new preprint from past lab member @HannahEBaughman.
We posted a manuscript of my postdoc research on bioRxiv yesterday. We characterize the transcription activation domain of RelA and found that it enhances the binding affinity of the p50/RelA heterodimer for DNA, especially for sequences that don't match the κB consensus motif.
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RT @paganolab: 1/4 Join us at this year's @FASEBorg summer conference "The Ubiquitin and Ub-like Proteins Conference: Cell Functions and….
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We're looking for a post-doc to join our BRCA1/BARD1 team. Lots of exciting science to be done. Contact Rachel @ klevit@uw.edu.
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Check out our new review highlighting recent structural and cellular insights into BRCA1/BARD1 recognition and activity at nucleosomes!.
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