Klara Hlouchova lab
@KlaraH_lab
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sequence space deep diving 🐟 synthetic & evolutionary biology lab @CharlesUniPRG and @BIOCEV_science 🇨🇿🇲🇽🇷🇺🇮🇹🇸🇰🇺🇦
Joined March 2022
super exciting work by our former student @tretyacv (now with Pilpel lab)! using unique ML assisted pipeline they identified thousands non-genetic mutations in large proteomic data, showing another layer of diversity that human proteome consist of 🪄.
biorxiv.org
Each stage of the Central Dogma contributes to proteome diversity through mechanisms such as heterozygosity, somatic mutations, transcriptional errors, and translational errors. As a result, a...
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late announcement for czech speakers ⏱️ Klara will be host of live show “Chat s astronomkou” held as a part of International day of women and girls in science, starting at 7pm, you can join here:
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RT @CharlesUniPRG: 🏅 The Neuron Foundation honoured top Czech scientists on Sunday 19 January at a gala evening at the National Museum in P….
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Thanks a lot @HZdrahalova for chatting about amino acids, life and life's amino acids 🪼.
O vzniku života na Zemi. O 20 aminokyselinách, které tvoří vše živé. O životě jinde ve vesmíru. O syntetické biologii. Opravdu o životě jsem si povídala s Klárou Hlouchovou @KlaraH_lab @PrirodovedciCZ @UniKarlova @ukforumcz @ERC_Research #ERCCoG
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Thank you @HFSP for remaining fans of Synbio & origins of life. Page 40 on our work with @ELSI_Fujishima @fried_lab 🌋.
🚨 HFSP Science Digest 2023 is out!.🔬Breakthrough life science research.🌍43 projects, 55 scientists, 26 countries.🧬A focus on synthetic biology & the origin of life .Explore how HFSP is advancing life’s frontiers:.👉#LifeSciences #HFSP #ScienceDigest
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Another annual pre-Xmas meeting of de novo & seq space explorers 🚀Thank you all for coming to Prague @bornberglab @hollfelderlab & IvarssonLab
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Thank you @ERC_Research, feeling truly challenged by this project and can't wait to see it unfold 🪁 The list of people to thank for the support is way too long, but I'm super grateful for everyone there ❤️.
All known living cells produce proteins from the same 20 coded amino acids. Now new research from Klára Hlouchová @science_charles aims to construct a bacterial strain relying on only 19!. Discover 👉 🇪🇺#FrontierResearch #ERCCoG
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Joining the fan club here, very deserved @HonzaDobes87 ! Super proud to be around you at @science_charles , thx to you immunology is way more than list of weird acronyms to us here, in the basement 🐉.
🎉👏 Dr. Jan Dobeš @HonzaDobes87 from our faculty at @CharlesUniPRG, has won the INVENCE #award at Česká hlava! 🔬 His research reveals how the #immune system fights #yeast infections. 🌟 Congratulations on this prestigious recognition! . 📌
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RT @czexpats: Jsme hrdí na spolupráci s @Bakala_Fdn , která nově podporuje anglický bakalářský program Science na @UniKarlova , inspirovaný….
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RT @4EUplusAlliance: 🌱 #GrowingInCreativity: One of the SEED4EU+ projects, RECHARGE, focuses on the interactions between proteins and RNA,….
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This example of “peptide-RNA” co-evolution using the very fossil of our biological life goes back to Oparin’s century-old theory about coacervate microdroplets during life’s origins. To be continued! 🦕.
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These protein fragments apparently go >4b yrs in our life’s history and we observed that they enable condensation of the protoribosome, protecting it from degradation, before it would gain more evolutionary layers and structural stability (spiced with MDs by @MhkoScience ).
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Ever wondered about those ribosomal proteins that send their “limbs” all the way to the ancient ribosomal core? Then follow this collaborative piece we loved working on with @MhkoScience @ELSI_Fujishima and Giuliano Zanchetta 🔗 @HFSP @4EUplusAlliance
academic.oup.com
Abstract. The ribosome, owing to its exceptional conservation, harbours a remarkable molecular fossil known as the protoribosome. It surrounds the peptidyl
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and maybe there will be something about importance of fiber in your diet. most probably not, but you never know these days
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also there’s a new review from Klara on how peptides could’ve bridge the gap between prebiotic modes of catalysis and the enzymatic as we know it now 🛣️.
pubs.acs.org
ConspectusIn the quest to understand prebiotic catalysis, different molecular entities, mainly minerals, metal ions, organic cofactors, and ribozymes, have been implied as key players. Of these,...
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checking in from Munich! Klara, Valerio and Ivan @IvanCherepashuk are here for the Molecular Origins of Life 2024 ☄️ Ivan’s missing from the photo, as his poster snoozed the alarm in Prague, don’t worry though, a new one will be at stand #5, poster session starts at 12pm!
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Our Prague HFSP mini-retreat with Steve Freeland is over. Annual report, science and out-of-lab adventure all done, our spirits lifted 🧪🌄🐉
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RT @majek_n: @Caro_S_Rocha has defended her phd thesis today - what a journey - thank you Caro - it was a pleasure to be your cosupervisor….
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our talented MSc student Vitek Kucera was presenting at #SynCell2024 in France today! we’re very proud and grateful to @SynCellEU for this opportunity 🙃 keep an eye on this young fella!
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