Finding the Four-Leaf CLOVERS: Biologic Subphenotypes and Fluid Tolerance in Sepsis @atscommunity 🔓 Open Access 🔗 https://t.co/YaTYdv3jS0

Clinician Prediction of Hyperinflammatory Acute Respiratory Distress Syndrome Subphenotypes Physicians did not accurately predict hyperinflammatory subphenotypes in patients w/acute respiratory failure using clinical data alone @KitsiosMd @PACCSM 🔗 https://t.co/94eGH9VLie

Have a look at our current @JCI_insight issue. I hope everyone loves the artwork provided by our soon-to-be-scientists!!

Come learn to study the lung microbiome at ATS 2025! Meet and learn from an all-star team of experts. San Francisco, May 16th.

@cleverwebber @ryankshields @IDPittStop @PranavJain23 @PACCSM_fellows @AJPLung I’m grateful to work with a great group of talented researchers and fantastic colleagues and friends. Here's to many more in 2025! 🥂 @PACCSM_fellows @PACCSM @PittDeptofMed @UPMCnews

@cleverwebber @ryankshields @IDPittStop @PranavJain23 @PACCSM_fellows @AJPLung And a bit huge shoutout to the many collaborative papers with great colleagues all over the 🌍. https://t.co/FQAv9m5nWE https://t.co/tghlj7ru3x https://t.co/6xzvxmkHSQ https://t.co/yOr2jvzvJQ

@cleverwebber @ryankshields @IDPittStop 🔟 With @PranavJain23 and @PACCSM_fellows, we "navigated the Extravascular Lung Waters of Pulmonary Edema in COVID-19 ARDS," reviewing a great study by Schippers et al. 💧🫁 Check out our take in @AJPLung: https://t.co/7flUCQ7Igg

9️⃣ With @cleverwebber, @ryankshields, and @IDPittStop, we did #Nanopore metagenomics of stool samples to detect #MDR Antibiotic Resistance in E.coli in a transplant recipient. 🔬🦠 Check out the study in @JAC_Antimicrob: https://t.co/QaKVZskACC

8️⃣ On the same theme of #ARDS #Subphenotypes, we explored their relationship to acute brain dysfunction—#delirium. 🧠 A cool study led by Niall Prendergast @timothygirard, @PittCCM, and @PACCSM. https://t.co/h61mpRSFW8 @AnnalsATS 🤯

7️⃣ Back to the recurrent theme of critical illness heterogeneity: @AmandaMoale @PACCSM explored how host response subphenotypes relate to code status de-escalation decisions in the ICU. @CHESTCritCare: https://t.co/tvBHtvSHfp Some really provocative findings...

6️⃣ Mark Snyder and I reviewed the role of the lung microbiome in Acute Cellular Rejection in Lung Transplant, with an @ATSBlueEditor editorial: https://t.co/gXDtOku0U5 A dive into the fantastic study by @JakeNatalini, @Leopoldo_Segal, and @benjaminwumd: https://t.co/8szqvlEE5M

5️⃣ Another exciting one in the same issue of @NatureComms! https://t.co/nQbgVCRUuq We explored trained immunity and the role of neutrophil heterogeneity and galectin-3 in Pseudomonas pneumonia. A true bench-to-bedside journey spanning all aspects of translational research. 🧪🛏️

4️⃣ The culmination of a multi-year effort! We mapped the longitudinal, multi-compartment evolution of host microbiota in critical illness in @NatureComms: https://t.co/tY9xuouuGS Massive project that took a village—@PACCSM, @TakisBenosLab, @UF, @LaiPeggy1, @MGH_PCCM, 👏

3️⃣ Switching gears to #LongCovid @BMJ_Open https://t.co/sxv8fREg4k Subphenotypes of self-reported symptoms and outcomes, with very low signal for viral persistence. Big thanks to @PACCSM, @PittDeptofMed, @Pitt_CMM, @IDPittStop, and @pfizer for their support on this one! 🧠🩺

1️⃣ We kicked off 2024 with an opinion piece in @AnnalsATS: https://t.co/6O3eUscHZT 🌟 It makes the case for #NonInvasive sampling of the lower respiratory tract in acute respiratory failure, which now evolved into a Workshop Report for @ATSCommunity @ATS_PITB. Stay tuned!

🚨 Self/Friend/Team Promotion Alert! 🚨 2024 has been a rollercoaster. Lots of hard work, many failures, a few successes...and many late nights ☕. Thrilled to share what we published in 2024 with my amazing colleagues at @PACCSM @UPMC! 🏥 Let’s dive into some highlights🧵⬇️

Outside the #ICLAF2024 conference, the changing of the guards at the Tomb of the Unknown Soldier is a place of reflection. It also allowed for some fantastic light. @ICLAF_2024 @PittDeptofMed

#ThisisPACCSM @PACCSM 👇

ID’ing ICU subphenotypes 🔴🔵 should help us find effective treatments 💉; but might they affect care in other ways? Just out in #journal_CHESTCritCare, @AmandaMoale, @KitsiosMd, et al evaluate their association with changing goals of care: https://t.co/bFqPCSrOZV

Next level in delirium treatment: From Traditional Typing to Intelligent Insights: A Narrative Review of Directions Toward Targeted Therapies in Delirium Excellent review by KM Potter & team https://t.co/z5N3gKGlpG