@ColoffLab

Could not be prouder of this work or more grateful to the whole team for this one. Shoutout to @ColoffLab for this original meme that *perfectly* summarizes the paper. Check out the final print here: ASCT2 is a major contributor to serine uptake in cancer cells: Cell Reports

Excited to announce my successful dissertation defense! It has been an incredible experience at UIC @ColoffLab

RT @biorxivpreprint: ASCT2 is the primary serine transporter in cancer cells #bioRxiv.

Huge thank you to @chidley_chris, @LabDeNicola, and @bensahralab for all of your help along the way.

🧵5. Finally, we find that loss of ASCT2 in combination with a serine-free diet leads to tumor regression in a xenograft model of ER+ breast cancer!.

🧵4. We find that serine uptake through ASCT2 is critical for purine nucleotide biosynthesis, and characterize a novel mechanism of regulation by ER!.

🧵3. If you've heard of ASCT2, its likely in the context of glutamine uptake. We show that glutamine and serine actually compete for uptake by ASCT2!.

🧵2. We show that ASCT2 contributes to serine uptake in both auxotrophic and non-auxotrophic cell lines. .

🧵We use a transporter-specific CRISPR screen to identify ASCT2 (SLC1A5) as the dominant serine transporter in luminal/ER+ breast cancer cells. .

Serine metabolism in cancer is well-understood and appreciated, but the identity of serine transporters has been a missing piece of the puzzle for too long. Check out my new preprint to find out more! 🧵.Thank you to the entire @ColoffLab for this one!.

RT @UICPhysiology: We are looking for an Assistant or Associate Professor who works at the intersection of cancer metabolism and tumor micr….

Such a cool paper and so proud to be a part of it. Go @ColoffLab !!!.

Guest Editorial: Bias in Mass Spectrometry Technical Support

RT @Pooyahat: I love the idea of 4-day workweeks. Think about the amount of research that can be done on 3 day weekends.