Katayoun Ayasoufi
@KAyasoufi
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Trained in transplant and neuro immunology. Interested in how brain cancer induces immune suppression. Assistant Professor at Duke University. Views are my own.
Durham, NC
Joined April 2019
Check our our new paper discussing brain TRM responses in health, acutely after neurological insults, and long after clearance of brain infection, and during antigen specific reactivation.
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Why?????.
Vought has ordered a halt on all extramural NIH funding for the rest of the FY. No words. You cannot let this stand @SenateDems @SenateGOP @NIHDirector_Jay @hubermanlab . Trump Administration Puts New Chokehold on Billions in Health-Research.
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Seems like end of an era for a lot of us scientists :( 4% payline is insane. this doesn't help anyone with cancer. While we are trying to find anything we can to improve GBM outcomes. this is what is happening. .
“With these considerations, we expect to fund through the 4th percentile.” . A crushing and utterly despicable blow to cancer research.
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As a new PI who is trying very hard to make it, 6 is limiting. This includes all co PI grants as well. I never use AI. But have already submitted 4 grants this year and would like to resubmit 2 since none are fundable first try. So it makes it hard for junior faculty to survive.
Does anyone have any clear opinions on this? It does not say you cannot use AI, but be careful when submitting @NIH grants. You cannot submit more than 6 in a given year. I wish I could submit 6 in a year.
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Sadly, this would mean the likely end of the field of Immunology. Things like the blood brain barrier, entry into tissues, process of memory generating and inter organ connections cannot be studied on a chip or using AI. So sad to see our dreams of discovery die. how to continue.
NIH announces end to funding for animal-only studies. This is potentially huge and needs clarification. Current NIH leaders may not understand the imposibility of making discoveries in fields like Immunology without in vivo models:.
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RT @MKhasraw: JCI - IL-7-mediated expansion of autologous lymphocytes increases CD8+ VLA-4 expression and accumulation in glioblastoma mode….
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We will not stop working until GBM patients have better prognosis. You are such an inspiration to all of us GBM researchers. I will continue to teach your case at my future classes and hope that one day we will make a difference in this devastating disease.
Unfortunately there is a larger volume of quickly growing brain cancer (glioblastoma, IDH WT, unmethylated etc) in my left brain. The prognosis is poor. Whilst some of my recurrent tumour was removed last week, some of it couldn’t be because of its site. While the neoadjuvant
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Congratulations @Cori_Fain ! So wonderful!.
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When you get NONE of the grants this year, go back to the lab and be your own postdoc. An Immunologist's happy place. To getting some grants in 2025! #newPI
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RT @BlethenKathryn: Are you interested in working in a translational research laboratory studying mechanisms to increase drug delivery acro….
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Another exciting finding from the awesome Peter Fecci lab! Very talented student/now postdoc Xanne Miggelbrink led this project! Cool new finding on how TNFR2 is a key player in CD8 T cell exhaustion! @PeterFecci @prtbtcatduke @Dukeneurosurg.
TNFR2 loss leads to decreased TOX expression in T cells without affecting TIM3 and improves responses to tumor and chronic LCMV #biorxiv_immuno.
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Congratulations! Wonderful work!.
Congrats to Jordan Isaacs @JordIsaacs! The first paper from the Rosato lab is out! tweetorial below
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RT @ErinMGibson: T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis | Nature Neuroscience http….
nature.com
Nature Neuroscience - The involvement of age-related myelin damage in Alzheimer’s disease is unclear. Kedia et al. show that T cell-mediated microglia activation triggers a response against...
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Thank you so much for visiting us! You are awesome, and your work is amazing! I look forward to future collaborations!.
Had a blast at the Duke Brain Tumor retreat last week @prtbtcatduke @Dukeneurosurg ! So much amazing and inspirational science going on there! honored to be a part of it- thank you for the invite! @KAyasoufi.
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RT @MKhasraw: Great program and speakers @PCRosato1 - fantastic organizers @KAyasoufi & Co @MattWaitkus.
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We are at the great @prtbtcatduke @Dukeneurosurg retreat! Amazing speakers including @PeterFecci @MKhasraw and many who are joy on tweeter! We are also honored to be hosting the great Dr. Rosato @PCRosato1 as our keynote speaker!
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RT @PeterFecci: Metastatic cancer treatments advance, offer new hope to patients - ABC11 Raleigh-Durham
abc11.com
"There's a lot of reasons to be optimistic even in the face of a terminal diagnosis."
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One of my lifetime heroes, Marc Jenkins giving an amazing talk on CD4 T cell memory at @ImmunologyAAI #AAI2024 . I hope he never retires :D
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