Kenneth Jacobson
@KAJacobson
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Dr. Jacobson is Chief of the Molecular Recognition Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases
Bethesda, MD
Joined May 2009
RT @AstrocytePharma: Great story by 7NEWS Adelaide covering @AstrocytePharma STARFAST Phase 2 clinical trial!!
facebook.com
EXCLUSIVE: A world-first trial is underway in Adelaide that could soon have a major impact one of the biggest issues facing sport. It is a revolutionary pill to treat concussion and it could end up...
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RT @AstrocytePharma: 🚀 More great news! @AstrocytePharma is honored to receive a $3M grant from the NIH to further advance the oral formula….
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Carolyn Bertozzi delivered an amazing Margaret Pittman lecture today at NIH, & succeeded to explain complicated bioorthogonal chemistry to the broader scientific audience.
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RT @AstrocytePharma: Astrocytes are stepping into the spotlight. 🌟.A trio of new Science papers reveals just how central these cells are to….
science.org
Astrocyte signaling pathways influence neuronal networks and behavioral responses to neuromodulators
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RT @EricTopol: Astrocytes have long been conceived as passive support player cells in the brain. But today @ScienceMagazine (via 3 reports….
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RT @AstrocytePharma: A great week at the #TBIconference—Astrocyte was thrilled to be part of the scientific exchange and momentum driving n….
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RT @AstrocytePharma: Summary of Astrocyte's Phase 1A clinical trial of AST-004 featured this month in @StrokeAHA_ASA's Article Commentary.….
ahajournals.org
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RT @PhysOrgChem_MU: Beautiful excursion into the history and importance of Photoremovable Protecting Groups: One of….
pubs.acs.org
Abraham Patchornik was born in 1926 in Ness Ziona, a town in Palestine founded by his great-grandfather Reuben Lehrer in 1883. He started to study chemistry as an undergraduate at the Hebrew Univer...
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RT @NIDDKgov: In an NIDDK study conducted with international support, researchers invented a light-activated psoriasis drug to selectively….
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RT @NIDDKgov: Researchers from @SLU_Official and NIDDK discovered activating a mitochondrial adenosine receptor (A3AR) protects rodent neur….
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RT @NIDDKgov: Serotonin, a molecule known for its regulation of neural activity and mood, can also cause inflammation. With reengineered mo….
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RT @NIDDKgov: In Journal of Medicinal Chemistry: NIDDK researchers discovered a new class of molecules, derived from existing antiviral and….
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RT @NIDDKgov: The researchers believe that studying these new molecules could lead to future treatment strategies for pulmonary arterial hy….
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RT @NIDDKgov: NIDDK scientists introduce “lipid trolling” to improve potency & efficacy of PAMs (positive allosteric modulators) of the A3….
pubs.acs.org
A3 adenosine receptor (A3AR) positive allosteric modulators (PAMs) (2,4-disubstituted-1H-imidazo[4,5-c]quinolin-4-amines) allosterically increase the Emax of A3AR agonists, but not potency, due to...
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Cryo-EM A3 adenosine receptor structures, from SIMM, with both of the potent and selective A3 agonists that are in advanced clinical trials by CanFite. We invented both molecules, and they are widely used in research, as well: IB-MECA and Cl-IB-MECA.
nature.com
Nature Communications - Adenosine A3 receptor (A3AR) holds promise for treating inflammatory and cancer conditions. Here, Cai et al. present cryo-EM structures of A3AR bound to agonists CF101 and...
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RT @AstrocytePharma: Meet with @AstrocytePharma at #ASCPT2024! Astrocyte’s Lisa Manna will be presenting our poster with @QPSHoldingsLLC on….
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RT @KrolsSimon: 🔊🔊 New manuscript alert! For a side project during my PhD we explored novel 7-deaza ribonucleosides with dual N6/C7 substit….
pubs.acs.org
Various purine-based nucleoside analogues have demonstrated unexpected affinity for nonpurinergic G protein-coupled receptors (GPCRs), such as opioid and serotonin receptors. In this work, we...
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