Juyeun Lee
@JuyeunLee31
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Postdoctoral researcher and immunologist @CCLRI Studying immune cells in glioblastoma. #sexdifferences #immunotherapy
Cleveland, OH
Joined July 2020
RT @JustinLathia: Incredibly proud that 2 of our papers are included in this highlight! The mitochondria transfer work led by @DionysiosWat….
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Join us for Brain Tumor Immunology mini-symposium in Vancouver @NeuroOnc this Thursday 1-4pm in room 121-122! #SNO2023.@mitralabcuamc @catdotflo @LijieZhai @KristenKay @JustinLathia @LuRongze @d_bayik @castro2355_mg @dwainwright_PhD.
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Excited to participate in #SITC 2023 Women In Network leadership workshop in Chicago!we've discussed the importance of having a sponsor, successful public speaking, and effective communication so far!
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RT @CD_AACR: #ICYMI—.Sex-biased #Tcell Exhaustion Drives Differential Immune Responses in #Glioblastoma, by @JuyeunLee31, @JustinLathia et….
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@d_bayik Lastly, another exciting work on the role of the male sex hormone in GBM is coming soon! Stay tuned 😉.
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@d_bayik 3/n Additionally, we identified T cell-intrinsic regulation of sex differences, partially mediated by an X chromosome inactivation escape gene, Kdm6a. Future studies will focus on elucidating the epigenetic regulation of T cell exhaustion by Kdm6a.
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@d_bayik 2/n Our findings further suggest that a higher ratio of progenitor exhausted T cells in male tumors may contribute to better resposivness to immune checkpoint inhibitor therapy, as reported in multiple cancer clinical trials.
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1/n We started this project to answer the question of why GBM patients do worse than female patients. In addition to our previous paper on MDSCs by @d_bayik, we found CD8 T cell exhaustion plays a significant role in GBM progression shown by mouse models and human validation.
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I'm super excited to have our paper published @CD_AACR! I truly appreciate all the support from the members of the Lathia lab and our collaborators. I feel incredibly lucky to have a fantastic mentor @JustinLathia 🕺.
Thrilled this is finally out! Great study led by @JuyeunLee31 & contributions from others - @MikeNicosia87 @EllenHong7 @DJ_Silver_PhD @d_bayik @DionysiosWatson @lauko_adam @KristenKay @sabrinazwang @desailabcwru @goodmunologist @2Scottish @BrainTumorDoc & others not on Twitter.
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Super excited to be at #aai2023 in washington DC. If you are interested in sex differences in T cells, come see my talk on Saturday morning or my posters P1059 and P928 on Friday and Saturday!
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Excited to be part of the Gordon conference at Ventura! #sexdifferences2023 #immunity @GordonConf @KristenKay @sabrinazwang.
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Check out our preprint paper on bioRxiv!.
Sex-specific T cell exhaustion drives differential immune responses in glioblastoma #biorxiv_immuno.
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RT @d_bayik: It was a pleasure to write this spotlight with @JuyeunLee31 and @JustinLathia highlighting the recent manuscript by @C_Alanio….
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Another hype train here at #AAI2022! Come and meet @MikeNicosia87 at poster P116 and find out how aquaporin 4 regulates DC function! Also don't miss his talk at 5pm about the role of LAG3 in kidney transplantation!
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RT @jclinicalinvest: Tumor Treating Fields: killing two birds with one stone: In this #Commentary, @JuyeunLee31, Ma….
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RT @CCLRI: New review published in NeuroMolecular Medicine about sex differences in #glioblastoma #immunotherapy response from @JuyeunLee31….
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Cover page @ImmunityCP this month! Beautiful illustration summarizing our findings on the mechanisms of glucocorticoid effect on regulating inflammation via Treg/miR-342.
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RT @ImmunityCP: Anti-inflammatory Roles of Glucocorticoids Are Mediated by Foxp3+ Regulatory T Cells via a miR-342-Dependent Mechanism http….
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