June Rhee
@JuneWRhee
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Physician-scientist interested in the Heart, Stem Cells, CRISPR, CHIP, and Cardio-oncology @cityofhope
Joined November 2017
New chapter in our #CH journey!. In 1,931 auto-HCT pts, CH was linked to a 2-fold ↑ risk of nonmyeloid subsequent cancer (SIR = 1.9). In multivariable analysis, CH remained an independent risk factor (HR = 1.72, 95% CI 1.15–2.59). Beyond CVD, CHIP shapes long-term solid cancer
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RT @JACCJournals: In this exploratory analysis, Tx w/ low-dose colchicine was assoc w/ an attenuated annual clonal growth in TET2 CH. Findi….
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The risk of MDS/AML w/ CHIP is well established. But our data show CHIP also raises risk of non-myeloid solid cancers after auto-HCT. Key takeaway: CH isn’t just about CVD or AML/MDS. It also drives risk for secondary solid cancers after HCT.
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In our recent studies, CHIP was common (~20%+) in our cohort of HCT recipients & associated with markedly ↑ risk of non-relapse mortality. CVD however didn’t fully explain the risk… so we asked: does CHIP also predispose to secondary cancers after HCT?.
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RT @montypal: A true legend in the field of hematology/oncology. Dr. Stephen Forman was involved in the seminal studies of BMT for hematolo….
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RT @KellyLBolton: Germline genetic variation has been linked to both hematologic cancer and clonal hematopoiesis. But does germline variati….
nature.com
Nature Genetics - The relationship between pathogenic germline variation, clonal hematopoiesis (CH) and risk of hematologic malignancy is explored in 731,835 individuals across 6 cohorts. Carriers...
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RT @jieliu09: Also deeply thankful to @AlexBickMDPhD, @pnatarajanmd, @jrblundell, @nilanjan10c, @carolinewatson, @hamish_macg, @DrFlashHear….
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RT @cityofhope: We’re honored to welcome world-renowned microbiome expert Kenya Honda, M.D., Ph.D. and his research team, to @cityofhope. I….
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Huge congratulations @RamaNatarajan. Well deserved and can’t think of any better person for this!.
Congrats to my mom @RamaRNatarajan for being named a WEILD (Women Elevating and Inspiring Leadership in Diabetes) Trailblazer!.@cityofhope
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RT @DrKTakahashi: 🚨 New paper in @NatureGenet !.How does cancer chemotherapy reshape the HSC landscape and drive the evolution of therapy-r….
nature.com
Nature Genetics - Analysis of whole-genome sequencing data from hematopoietic stem and progenitor cells taken from patients with myeloma shows how treatment shapes clonal architecture and sheds...
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RT @DrHelenECollin1: For all your BCVS related news, check out the latest Basic Beat newsletter that should have arrived in your inbox this….
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Today, I wanted to post something personal so that I can remember :). Today is a bitter sweet day to say goodbye to our wonderful lab manager and RA, Brittany, as she moves on to the next chapter of starting her dental school!. I’m so thankful for everything she did for the lab.
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RT @Joseph_C_Wu: We're pleased to see our work on vascularized cardiac & liver organoids published in @ScienceMagazine. Congrats to @oscar….
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RT @NatureBiotech: EPI-Clone is a transgene-free lineage tracing method that uses single-cell DNA methylation analysis to track hematopoiet….
nature.com
Nature - The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell...
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He’s the best. An amazing clinician and scientist. Grateful to call him as my friend and colleague! @Joseph_C_Wu @StanfordCVI @FaRodriguezMD.
We're proud to announce that #StanDOM's Karim Sallam has been named the 2025 recipient of the Alwin C. Rambar – James B.D. Mark Award for Excellence in Patient Care. His compassion, dedication & teamwork define excellence at @StanfordMed. Congratulations, Karim!
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RT @BCVSearlyCareer: Are you ready to electrify the stage at this year’s #BCVS25 Council Dinner in Baltimore?. Whether you sing, dance, or….
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RT @parkerici: For patients with lymphoma that relapses after CAR T, clinical options become vanishingly few. Now, a new study in @NEJM led….
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