Jonathan Clayden
@JonathanClayden
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Professor of Chemistry (molecular synthesis, shape, function). Amateur of growing, cooking, & eating things; of music, cycle-commuting, botany, & Oxford commas.
Bristol, England
Joined June 2016
RT @WoolfsonLab: Super excited that our work on the rational design of 310-helical bundles is now out in @Nature! Congrats Prasun @dgr8asho….
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Marina Hyde's always good value but she's brilliantly on fire today.
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Well done to Matthew Wootten for working out how to use a simple idea to create complex conformational behaviour in mixtures of chiral acids, bases, and a metal.
Our latest Pick of the Week is on molecular communication💬, by @JonathanClayden from @BristolChem! The @ClaydenGroup demonstrate communication of a conformational response to a spatially remote site 🔥. Read this #ChemSciPicks article for free: 🔗
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RT @angew_chem: Triarylmethanes and their Medium-Ring Analogues by Unactivated Truce-Smiles Rearrangement of Benzanilides @ClaydenGroup #op….
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Some good news from the ERC arrived in my in-box last week :-)
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RT @ChemCambridge: With sadness, we are remembering our colleague Dr Stuart Warren who died yesterday. See our story about him here: https:….
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RT @nature: Alkylation of amino acids has resulted in active pharmaceuticals and building blocks for unnatual peptides. Now a general route….
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RT @HansellThe: From @JonathanClayden ‘s group and we totally should have done tagging in the ‘official’ tweet. *shakes fist at Official Na….
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RT @ERC_Research: A new way to modify amino acids, useful for synthesizing new medicine molecules. “This work allowed us to turn what was a….
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RT @BristolChem: Modification of amino acids provides new starting point for development of medical treatments - latest research from @Jona….
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RT @john_w_ward: Extremely proud of our work from @JonathanClayden group on the asymmetric α-arylation of amino acids published in @nature….
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Just out! At last a way to introduce (almost) any aromatic ring to the central C atom of (nearly almost) any amino acid, making either mirror image product at will: Asymmetric α-arylation of amino acids
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‘Natural substances’ and a natural woman | Brief letters
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The latest method from the Clayden Group: move over Pictet and Spengler. !.Consecutive Ring Expansion and Contraction for the Synthesis of 1‐Aryl Tetrahydroisoquinolines and Tetrahydrobenzazepines - Angew Chem Int Ed
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Collaborations with GSK can inspire all sorts of publications:
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RT @angew_chem: Medium-Sized-Ring Analogues of Dibenzodiazepines by a Conformationally Induced Smiles #RingExpansion (Clayden) https://t.co….
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A tendril perversion (that kink in the telephone cable on your desk) trapped inside a helical molecule.
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Our new way of making medium (8-12 membered) benzo-fused N heterocycles by a ring-expanding aryl shift.
Medium-ring nitrogen #heterocycles through migratory ring expansion #OrganicSynthesis @jonathanclayden
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