JonasPoehls
@JonasPoehls
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PhD student in proteomics and computational biology @MPICBG. Talk to me about: Protein translation, Mass Spec, D&D, Martial Arts, books of all kind.
Joined August 2022
💫September Condensate of the Month is +TIP body!💫 These #condensates form at the growing plus end of #microtubules, crucial for cell division and transport.🦠🧫 : https://t.co/bsjss50s6A Check out the protein composition of +TIPs in different organisms ⤵️
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🌟Excited to introduce #MARDO as CD-CODE August "Condensate of the Month"!🌟 MARDO stands for Mitochondria-Associated RNA DOmain: https://t.co/nzveUrWBDf 💡It was first discovered and described by Cheng et al. @SchuhLab in #mammalian (mouse, bovine and human) #oocyte. 1/3🧵⤵️
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📢We've just updated CD-CODE to v1.06!🎉 ✨11 new #condensates integrated (total: 670) ✨ 21 new #proteins associated (total: 9672) ✨ 24 condensate-protein attributes updated 👀Check the current version here: https://t.co/CN4je5FqWH
#DatabaseUpdate #NewRelease #Bioinformatics
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The @agnestothp group w/ PhD student @FedeLuppi2 in collaboration w/ @ccassa & Ivan Adzhubei @harvardmed developed DeMAG, an open-source web server to help interpret mutations in disease genes and improve clinical decision-making. Published @NatureComms
https://t.co/7i0CamMuTY
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I am proud to share the beautiful work of my very first PhD student @FedeLuppi2 in collaboration with @ccassa and Ivan Adzhubei @harvardmed, just published @NatureComms: https://t.co/mOD0P53Ppn
@mpicbg @csbdresden @PoLDresden
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CrowDsourcing COndensate Database and Encyclopedia (CD-CODE) is a community-editable platform for verified biomolecular condensates and their protein constituents. @soumyadeep11194, @agnestothp, @HymanLab, @mpicbg, @PoLDresden
https://t.co/16W3CsjRU4
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Our latest preprint on how low temperature and nutrient scarcity lead to increased levels of stop codon miscoding in E.coli https://t.co/JGONfPpu8C. Congratulations to all the authors! @RomeroRomeroML @JonasPoehls @mpicbg @csbdresden @LabShevchenko
biorxiv.org
Stop codon miscoding events give rise to longer proteins, which may alter the protein’s function and thereby generate short-lasting phenotypic variability from a single gene. In order to systematic...
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Glad to share our latest contribution to the field of protein design: “Active site center redesign Increases Protein stability preserving catalysis in Thioredoxin”. https://t.co/NpZgKOdZx4
@mpicbg @csbdresden @WeizmannScience @canalUGR @IBMB_CSIC
onlinelibrary.wiley.com
The stabilization of natural proteins is a long-standing desired goal in protein engineering. Optimizing the hydrophobicity of the protein core often results in extensive stability enhancements....
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Protein Evolution Special Issue in Honor of Dan Tawfik was published yesterday. Congratulations to @RomeroRomeroML, @cedric_landerer and @JonasPoehls for your contributions! https://t.co/6PKCgnT3QQ
onlinelibrary.wiley.com
Errors in DNA replication generate genetic mutations, while errors in transcription and translation lead to phenotypic mutations. Phenotypic mutations are orders of magnitude more frequent than...
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