Accepting applications from highly motivated Masters degree holders with prior research experience to take on interdisciplinary thesis projects in Dresden on the physical properties & biological functions of Biomolecular Condensates. Apply before 24.10.: https://t.co/8pWxOebO16

🧬 We're excited to host the 13th Symposium on Structural #Proteomics at HT in Milan on 6–8 Oct 25! Join this international meeting with talks on protein structure and interactions by crosslinking MS, HDX-MS, native MS, chemoproteomics & more 👉 https://t.co/sBtEJXSC3t

Scientific research is at the heart of Israel’s success and has worldwide benefits. Our work will continue despite adversity, says Alon Chen https://t.co/Qvcq1MbEnI

Congratulations to the amazing team of @williswows @MScheremetjew, @soumyadeep11194, @AHadarovich and @HongKee and Lena from the Scientific Computing Facility at MPI-CBG! 🎉

Are you looking for homologous sequences but alignments do not seem to work? SHARK-dive is available as a webserver 🦈: compare any sequences or search against precomputed IDR datasets: https://t.co/aOzm4B65rj @NAR_Open @csbdresden @PoLDresden MPI-CBG

We conclude that new IDR-specific features and paradigms are needed to accurately classify disease mutations within those regions. Disorder-to-order transitions predicted by AlphaFold3 and motif predictions (e.g. by SHARK-capture) may aid structure-based variant interpretation.

The distance to the second Methionine discriminates between pathogenic and benign variants associated with the N-Methionine site.

Mutations at the N-Methionine site are prevalent. Look at the surprisingly high peak at position 1.

Most mutations in disordered regions are benign but ~12% of pathogenic mutations fall within a disordered region.

The correlation between the disorder predictors is low.

It depends which disorder definition (score) is used. Only 7% of residues are consistently predicted as disordered across five different disorder prediction tools. flDPnn under predicts disorder compared to other methods.

State-of-the-art VEPs tools have lower sensitivity but higher specificity for variants in disordered regions.

Deep learning tools predict variants in disordered regions with lower sensitivity. Just published by FedericaLuppino, @swantjelenz and @williswows @mpicbg @csbdresden @PoLDresden

Exciting news for new #students! This year our #international 'Physics of Life' MSc program will offer 3 #scholarships - share and spread the word! 🤓 Learn more: https://t.co/6xlVZOinsS Students receive €300/month for 1 year, funded by Friends & Supporters of TU Dresden

Many thanks to the IPF and Friends of IPF for the Innovation Award 2024 and big congrats to the whole team! https://t.co/0r7S0N7hIh

I'm thrilled and grateful we have received the EXIST Forschungstransfer grant for commercialization of our DNA-nanotech-powered cell culture material platform DyNAtrix. https://t.co/nPKanGsdJ3

Now accepting applications for the Max Planck-Weizmann Joint Postdoctoral Program: • Full four-year fellowship • Advanced research facilities and access to leading experts • Enhance career perspectives • Comprehensive family support. For more info and to apply >>

Who does that? We rented a train JUST for the conference, that will take the participants from Prague to the woods of Bohemia. There'll be talks ON THE TRAIN. In Prague we'll have 5 locations with different atmospheres. #theconferencetoendallconferences Register now:

🚨Applications are now open for the 'Physics of Life' #MSc at the CMCB! Learn from leading researchers in the field of #biophysics This is an international, interdisciplinary programme that is tuition-free and taught entirely in English. Learn more: https://t.co/WzT0GHq1ao

News on SHARK-capture. Thanks to @williswows @swantjelenz @soumyadeep11194 @Alberti_Lab_TUD and all co-authors not on X.