Jim Johnson, PhD
@JimJohnsonSci
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Mentor, Physiologist, Prof / Assoc. Director, charity cofounder, exPharmaVP, Dad, HockeyGuy. Views≠employer's RT≠endorse he/him/ same handle on Bluesky
Ethernet
Joined April 2012
We are delighted to host the 2nd Annual Susie Clee Memorial Lecture this Thursday 4pm PST which will be given by Dr Melkem Kebede of the University of Sydney.
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This is a shame but I saw this coming 10 years ago.
Major news #Novonordisk $Nvo Novo Nordisk is ending its cell therapy venture entirely. After 25 years of research and multi-billion-dollar investments, the company is giving up on the dream of curing diabetes through cell therapy. No marketable results ever emerged. Around
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Human #genetics implies that therapeutic inhibition of SLC30A8, mediating zinc transport up to and including complete knockout, may treat type 2 diabetes safely and effectively @DiabetologiaJnl
link.springer.com
Diabetologia - Genetic association studies have demonstrated that partial loss of SLC30A8 Function protects against type 2 diabetes in humans. We investigated the impact of complete loss of SLC30A8...
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A study about the @IPTNCanada Remission Possible Website
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Very excited to share our preprint on #AI directed Deep Visual Proteomics (DVP) on #PancreaticCancer precursor lesions (PanINs), in collaboration with @OmicVision @MundAndreas Thousands of proteins from as few as ~100 precisely microdissected cells in archival samples!
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Delighted to share the preprint on the largest obesity GWAS to date! GWAS from >2 million participants Key: ✳️13% increase in loci discovery ✳️Identified 11 obesity genetic clusters (endotypes) ✳️Obesity management should be as diverse as the condition itself Thread👇
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How conmon is monogenic #obesity The answers depends where and how you look #genetics
https://t.co/7SEdR6MEMP
@IntJObesity
nature.com
International Journal of Obesity - Detecting monogenic obesity: a systematic exome-wide workup of over 500 individuals
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What an incredible day on June 2! Over 300 researchers, clinicians, community partners & research collaborators came together at the #VCHRIResearchSummit to celebrate research excellence. ❤️Thanks to everyone who made this event unforgettable! https://t.co/PN9347zDkj
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🚨 Due to limited guidelines and access for Type 1 Diabetes patients on low-carbohydrate ketogenic diets, we created official international LOW-CARB HEALTHCARE guidelines for managing Type 1 Diabetes. Developed by experts and people with T1D, these empower healthcare
The answer isn’t simple, but it is urgent: Our institutions have lagged behind the evidence and sometimes impeding change — failing both patients and healthcare professionals. Take the USDA Dietary Guidelines for America, as one example, which heavily influence: 1) school
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Excited to share our preprint! “A Temporal Single-Cell Multi-Omics Atlas of Murine Pancreatic Islet Remodeling During Hyperglycaemia Progression” here’s what we found👇(1/n) #IsletBiology #SingleCell #DiabetesResearch
biorxiv.org
Pancreatic islets undergo coordinated cellular remodeling during obesity-induced insulin resistance (IR). However, the associated molecular changes across endocrine and non-endocrine compartments...
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Today I stumbled upon a remarkable case report of a boy born with congenital insensitivity to pain who led to the discovery of a USP5, encoding a deubiquitinase enzyme, as an important regulator of pain sensitivity. The boy, born slightly early, initially appeared healthy but
cell.com
T-type calcium channels contribute to nociceptive signaling. García-Caballero et al. find that the deubiquitinating enzyme USP5 interacts with Cav3.2. Knockdown of USP5 or disrupting USP5-Cav3.2...
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🧬 Explore how state-of-the-art regenerative medicine is transforming healing. Join us on Jun. 2 at the #VCHRIResearchSummit session with Drs. Joanne Matsubara & Dena Shahriari, moderated by Dr. Jim Johnson. Secure your spot today: https://t.co/ASktyeoScq
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EIF2A is a novel target for beta cell protection and the circumvention of EIF2S1-mediated translational repression #islets #diabetes @JimJohnsonSci @DiabetologiaJnl
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📢 Applications are now open for the 2025 UBC Healthy Aging Postdoctoral Fellowship! 💰 $60,000 + benefits (1 year, renewable) 🗓️ Start between Sept 2025–March 2026 📅 Apply by July 15, 2025! 🔗 Info: https://t.co/a9DmXyEWw4
#Postdoc #HealthyAging #UBC #ResearchOpportunity
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2 female German tourists, 18 and 19 y.o., were detained in Honolulu for a terrible ‘crime’ of not pre-booking a hotel for their trip. Before deportation, they had to spend the night at the detention center. News like that will certainly do wonders for Hawaiian tourism industry🤡
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Brexit was meant to be a win. Instead, the UK lost 330,000 jobs. Exports tanked by 27%. Imports collapsed by 32%. London’s financial crown? Gone. Brexit didn’t free Britain. It broke it. Here’s the brutal truth no one’s talking about:
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My thoughts exactly.
The protests will grow. Whether U.S. media covers it properly or not is a different story. Keep growing these, America. Canada wants you back.
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The protests will grow. Whether U.S. media covers it properly or not is a different story. Keep growing these, America. Canada wants you back.
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