I’m excited to share our pre-print where we utilize #zebrafish to delineate how PAX3::FOXO1 initially interfaces with and modifies #chromatin in vivo. I’m grateful for the mentorship of @KendallLabNCH and Ben Stanton, and work from amazing co-authors!

Last, but not least, I’m grateful for the wonderful collaborations with Lex Tallan, Cenny Taslim, Meng Wang, Katie Silvius, Benjamin Sunkel, @StephLahaye, Qi Liu, @JunQiLab for making these papers possible!

I’m thankful for the support from the @nationwidekids @theNCI-funded #childhoodcancer T32 program, @NCHforDocs, @ASCatOSU MCDB program, and @OhioStateMed.

Additionally, in work led by Lex Tallan, we also developed a PerCell chromatin sequencing computational pipeline for quantitative comparative epigenomic analysis between experimental conditions.

From our model, we find that PAX3::FOXO1 a) binds to inaccessible chromatin through partial motif recognition of homeobox sequences and b) generates a neomorphic chromatin landscape to activate neural transcriptional programs that are associated with the human disease.

Thrilled that our work was selected as @Dev_Bio_Journal 2023 Paper of the Year 🎉

New review from my group led by graduate students, @JackKucinski and Delia Calderon. Hope you enjoy! Biological and therapeutic insights from animal modeling of fusion-driven pediatric soft tissue sarcomas https://t.co/ftrHww8xHk And a great experience working w/ @DMM_Journal.

First @AACR meeting was a success! It was great to share my work and listen to and meet so many fantastic cancer researchers.