Paul Ogongo
@JaTcells
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Human immunity. Infectious diseases. T-cells. Mycobacterium tuberculosis. Helen Hay Whitney Foundation Fellow.
Joined February 2015
New Study: We report the dysregulation of CD4 T cell responses by Type 2 Diabetes in people with TB. Increased circulating Th17 cell subsets and altered CD4 maturation and differentiation. Potential explanation for high risk for TB in those with T2D https://t.co/YjKDuh0ZeM
frontiersin.org
IntroductionType 2 diabetes (T2D) is a major risk factor for developing tuberculosis (TB). However, understanding the role of defective T cell responses in T...
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Meeting Report: TB Vaccine Forum meeting report is now out. https://t.co/kyCt6KlPk6
pubmed.ncbi.nlm.nih.gov
We urgently need novel, effective, and accessible vaccines to end tuberculosis (TB) as a public health crisis. The 7th Global Forum on TB Vaccines was convened from 8-10 October 2024 in Rio de...
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Spatial profiling reveals TREM2+ macrophages as central to Mycobacterium tuberculosis pathogenesis in human pulmonary tuberculosis https://t.co/RkO1NYwluA
#biorxiv_immuno
biorxiv.org
Tuberculosis (TB) remains a major global health challenge. While organized granulomas have long been the focus of TB pathogenesis research, the early development of TB pneumonia typically preceding...
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Protection against reinfection with Mycobacterium tuberculosis extends across heterologous Mtb lineages
biorxiv.org
Immunological memory elicited either through previous or ongoing M. tuberculosis (Mtb) infection provides a critical mechanism by which hosts protect against re-infection and disease progression upon...
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The fifth episode in our #TBImmunologySeries ft. @AneleGela, a Research Officer at @satvi_uct, @UCT_news , where he studies host determinants of protective immunity against #tuberculosis. #Immunology #Vaccines #TB #Tuberculosis #SciComm #GlobalHealth #PublicHealth #Immunity
Launching April ending, our #TBImmunologySeries features leading scientists whose work cut across TB prevention, diagnosis, treatment, and vaccine development. #tuberculosis #TB #immunology #immuneresponses #vaccines #globalhealth #immunesystem
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The fourth episode in our #TBImmunologySeries ft. @docjauro, a veterinarian & postdoc at @PittTweet, where he studies #TB in #macaque models. Listen here: Spotify: https://t.co/mPixTzuRmN Amazon Music: https://t.co/p8jfJStfJq Apple Podcasts: https://t.co/oU4Z9VBJ76
Launching April ending, our #TBImmunologySeries features leading scientists whose work cut across TB prevention, diagnosis, treatment, and vaccine development. #tuberculosis #TB #immunology #immuneresponses #vaccines #globalhealth #immunesystem
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Finding and filling the knowledge gaps in mechanisms of T cell-mediated TB immunity to inform vaccine design
nature.com
Nature Reviews Immunology - T cells have an essential role in immune responses to Mycobacterium tuberculosis, but the mechanisms by which they may provide protective immunity remain poorly...
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It was my pleasure to be interviewed by @immunoafrica_ for this episode of Immunology to TB. Here I share my journey as a scientist and our contributions to TB vaccine development.
Listen here: Spotify: https://t.co/YqIvBT0Tjc Amazon Music: https://t.co/ENuoRBafBL Apple Podcasts:
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Mycobacterium tuberculosis suppresses protective Th17 responses during infection through multiple mechanisms https://t.co/pAsGCNykVS
#biorxiv_immuno
biorxiv.org
Mycobacterium tuberculosis (Mtb) causes more deaths annually than any other pathogen, yet an effective vaccine remains elusive. IFN-γ–producing CD4+ T cells are necessary but insufficient for immune...
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Recent Findings show that early T cells at the site of PPD antigen challenge are not Mtb-specific. Evolution of T cell responses in the tuberculin skin test reveals generalisable Mtb-reactive T cell metaclones
biorxiv.org
T cells contribute to immune protection and pathogenesis in tuberculosis, but measurements of polyclonal responses have failed to resolve correlates of outcome. We report the first temporal evaluat...
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Positive and uplifting progress. Congratulations @Thumbi_Ndungu and entire study team and participants
Researchers at UKZN say an HIV cure could be on the horizon. After a two-year field test, a third of the participants managed to suppress the virus without medication for nearly a year. Professor Thumbi Ndung’u from UKZN explains. #DStv403 #eNCA
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Our combination immunotherapy clinical trial shows some promise towards ART-free HIV control. This offers hope for a HUV cure. Great collaboration between the community and multisector stakeholders. @Afroscientist
@dchopera
@ragoninstitute
@VictoriaKaspro
@UCLInfectImm
The 1⃣st HIV cure trial in Africa shows that 20% of trial participants remain off ART & virally suppressed after 1,5 years. ✅ Led by @Thumbi_Ndungu & @UKZNCHS colleagues, the results provide insights toward the development of future HIV cure approaches
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Significant progress in TB control efforts over recent years. The future of these achievements shouldn’t be in the balance because of uncertainty in funding modalities.
Learn about how faculty at the UCSF Center for Tuberculosis are waging the fight against #TB
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The optimism of controlling TB is dampened by uncertainty of NIH funding. TB research has come from so far, with sparse but significant successes. It is sad to see all that likely go to the drain and plenty of careers ruined. #KeystoneTBsymposium
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Congratulations @ProfTtweetsTB and colleagues
Paper: MTBVAC induces superior antibody titers and IgG avidity compared to BCG vaccination in non-human primates https://t.co/LpzxxNQMiU
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Check out new story with collaborators at TGEN. CRESTA, a new approach to identifying Mtb antigen specific T cells with high order of magnitude. Happy to have played a role.
Integrated, high-dimensional analysis of CD4 T cell epitope specificities and phenotypes reveals unexpected diversity in the response ... https://t.co/BXD2bvXzZo
#biorxiv_immuno
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Immunopeptidomics informs discovery and delivery of Mycobacterium tuberculosis MHC-II antigens for vaccine design https://t.co/JjvztUvbwe
#biorxiv_micrbio
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Thanks @TheBrysonLab for the tweetorial as always and the cool science!
Many of the peptides we identified are immunogenic per IEDB. We teamed up with @JaTCells to examine T cell responses to novel epitopes in a small cohort of individuals with prior Mtb exposure and found that some of these novel epitopes identified by MS are also immunogenic.
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