John Maraganore ๐บ๐ธ๐ฌ๐ท๐บ๐ฆ๐ฎ๐ฑ
@JMaraganore
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Founding CEO of @Alnylam. Pioneered RNAi therapeutics as a whole new class of medicines for patients. Now bioentrepreneur-at-large. Opinions are my own.
Boston, MA
Joined June 2017
RT @ScottGottliebMD: From @dgingery on continued departures from FDAโs biologics division and challenges backfilling openings. FDA biologicโฆ.
insights.citeline.com
The Center for Biologics Evaluation and Research saw departures far outnumber new hires in the second and third quarters of FY 2025, before more than 100 people left July 14 after the reduction-in-...
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Thanks for this Brad! . Henri was a friend and mentor, and SO important to everyone in biotech focused on patients!.
๐๐ซ๐จ๐ฎ๐ง๐ ๐๐๐ง๐๐๐ฅ๐ฅ: Did you know that there is a park and statue in Kendall Square in honor of one the pioneers of biotech?
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RT @ScottGottliebMD: FDAโs cancer review teams have lost about 1/3 of the medical review staff that oversee products for breast and gynecolโฆ.
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This is the right move!. Bravo, @Sarepta!
statnews.com
Sarepta will halt all shipments of Elevidys, its drug for Duchenne muscular dystrophy patients, by Tuesday evening.
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Very excited about this progress at Orbital!.
Circular RNA startup Orbital unveils first monkey data as it enters in vivo CAR-T cell therapy race - via @endpts @RLCscienceboss.
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Iโm sorry @Sarepta, this is just wrong!. IMO, our industry must always put patients first and we must be transparent to secure public and stakeholder trust. We also must hold each other accountable.
UPDATED:. Sarepta Therapeutics $SRPT crisis is huge blow to Duchenne families, company . Company has refused FDA request that it pull gene therapy from the market following patient deaths.
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RT @statnews: A well-placed biotech investor says U.S. policies are straining life sciences startups โ and more disruption is coming. httpsโฆ.
statnews.com
A well-placed biotech investor says U.S. policies are straining life sciences startups โย and more disruption is coming.
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Entire issue of โฆ@JACCJournalsโฉ dedicated to ASCVD prevention. โWhat is needed now is coordinated, urgent, and context-aware action to finally move from possibility to prevention.โ. The time is NOW!
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RT @LifeSciVC: Big late stage win for Takeda! . Oveporexton (TAK-861) hits on all endpoints in narcolepsy for the first-in-class orexin reโฆ.
takeda.com
Takeda (TSE:4502/NYSE:TAK) today announced that all primary and secondary endpoints were met in two Phase 3 randomized, double-blind, placebo-controlled studies of oveporexton (TAK-861), a potential...
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A U.S. brain drain will have devastating consequences for our global leadership!.
I saw it firsthand at the #Lindau2025 Nobel Laureates meeting--international young scientists welcomed and recruited in Germany and elsewhere. Some of the very best are leaving, and many of the best will no longer come.
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R.I.P. Frank! Thanks for โthe most beautiful experiment in biology!โ
nytimes.com
He and a colleague proved a theory advanced by the Nobel Prize winners James Watson and Francis Crick, who discovered DNAโs helical structure.
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โOn current trend lines, if weโre not careful, [China] could pass us. They are not just borrowing our ideas and adapting them anymoreโtheyโre coming up with new ideas. In fact, many heavily cited biotechnology research papers are being produced in China.โ.
Biotech has major implications for our economy and national security. I spoke with @ISSUESinST about how biotechnology can strengthen Americaโs warfighters, modernize agriculture, and enhance life sciences.
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RT @ianbremmer: united states cumulative measles cases in 2025: 1,277 (at least).highest count in 33 years. really can't stand the anti-sciโฆ.
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Without basic NIH-funded research in โblack boxโ diseases like Alzheimerโs and depression, weโll never have cures and treatments!. Is this really the right decision?.
Summary Table of the massive defunding of biomedical research in the United States
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RT @BillGates: The facts are simple and devastating: Aid cuts have already cost lives, and the number of deaths will continue to rise. Hereโฆ.
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So fun for Christine and I to meet our favorite โฆ@CNNโฉ reporter, the great โฆ@kaitlancollinsโฉ!
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Happy 4th to ALL!!!. While we have our challenges, the USA remains the greatest country in the world! . We are all blessed to be here!
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Tom Frieden: Kennedy mangles science in global vaccine decisionโฆ. โTranslation: The finding of an increased risk of death is bullshit.โ
statnews.com
โI was literally nauseated by Kennedyโs remarksโ about Gavi, the Vaccine Alliance, writes former CDC Director Tom Frieden.
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RT @flora_peyvandi: In patients with #uncontrolled hypertension in treatment with indapamide, amlodipine, or olmesartan, the addition of siโฆ.
jamanetwork.com
This randomized clinical trial examines the efficacy and safety of zilebesiran vs placebo when added to a standard antihypertensive medication in adult patients with uncontrolled hypertension.
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