MCRI Jaffe Lab
@IrisJaffeLab
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Executive Director of the Molecular Cardiology Research Institute, Physician-Scientist, Eagles fan
Joined November 2018
New from the @IrisJaffeLab! 🙌 Ponatinib, a potent anticancer therapy, activates #EndothelialCells and platelets, driving plaque inflammation and death from MI and stroke in mice, mirroring clinical cardiotoxicities in patients with cancer. | @CircAHA 🔗 https://t.co/oBKhd0PJxs
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Tufts Medical Center-Led Study Identifies Safer Path Forward for Cancer Patients at Risk of Heart Disease | @TuftsMedicalCtr @TuftsMedSchool @TuftsMCResearch
tuftsmedicine.org
Tufts Medical Center researchers find safer cancer drug option for patients at risk of heart disease, identifying a key mechanism behind treatment-related cardiac events.
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Congratulations Tufts MD-PhD student Alec Stepanian and @TuftsMedicalCtr Molecular Cardiology research Institute team. @TuftsMedSchool @TuftsMCResearch
pubmed.ncbi.nlm.nih.gov
Ponatinib, a potent anticancer therapy, activates ECs, platelets, and leukocytes, driving plaque inflammation and death from MI and stroke in mice, mirroring clinical cardiotoxicities in patients...
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Members of our Molecular Cardiology Research Institute volunteered with @communityserv yesterday to prep medically tailored meals for people with heart failure, diabetes, kidney disease and HIV. Proud to support patients beyond the lab. #TuftsMedicine @irisjaffelab
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Happening now at #AACR25 @TuftsMedicine + @TuftsMedSchool's @IrisJaffeLab presents Cardio-Oncology: A Novel Platform for Investigation. Room E353C 10:15am - 11:45am CST. #CancerResearchSavesLives #TuftsMedicine
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The talk describes a new mechanism discovered in @IrisJaffeLab showing how drugs that treat certain leukemias also cause heart attacks + strokes in cancer survivors. This research sets the stage for new treatments to protect leukemia survivors from CV side effects #AACR25
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Congratulations Alec Stepanian on a fantastic presentation. Alec was one of only 10 MD/PhD students across the country chosen to speak at the ASCI/AAP meeting in Chicago. @TuftsMedSchool @TuftsMedicalCtr @hboucher3
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Congratulations Alec Stepanian on a fantastic presentation. Alec was one of only 10 MD/PhD students across the country chosen to speak at the ASCI/AAP meeting in Chicago. @TuftsMedSchool @TuftsMedicalCtr @hboucher3
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The definition of bridging the #bench-to-bedside divide: Iris Jaffe is the inaugural director of the Tufts University–Tufts Medicine Research Enterprise #transformative @TuftsUniversity @TuftsMedicine @IrisJaffeLab
https://t.co/1Aq1vTNpbY
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Congratulations Lauren Biwer on receiving the Early Career Investigator in Atherosclerosis Award at Vascular Discovery. @TuftsMedicine @YaleMed
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#TuftsMedicine’s @NavinKapur4 presents at #THT2025 on Safety and Efficacy of the preCARDIA System to Mechanically Reduce Cardiac Preload for Acutely Decompensated Heart Failure. 📍 Ensemble A-B | Level 2 ⏰ 7:55 – 9:12 am #Cardiology @IrisJaffeLab
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Congratulations Alec Stepanian for a fantastic presentation and for winning the Jonathan Epstein Scholar award at the 227th ICC meeting. @TuftsMedicalCtr @TuftsMedSchool @TuftsMCResearch
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Our amazing #bircwh scholars at the annual meeting @NIH_ORWH @ErikaWernerMD @IrisJaffeLab @TuftsMedSchool @TuftsNutrition
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Congratulations Casey Turner on her F32 grant from the NIH and her mentor Jennifer DuPont. @TuftsMedicalCtr @TuftsMCResearch
An exciting day in the lab celebrating @CaseyGTurner1 's F32 award! Thank you to our MCRI colleagues for celebrating with us and to the @NIH for supporting our trainees! @IrisJaffeLab @BlantonLab @karla_cmarqs @amandakmauro @nicolelorrainew @TuftsMCResearch
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Congratulations Nicole Wolter, Tufts MD PhD student for her AHA early career travel award. @TuftsMedSchool @hboucher3
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Fantastic talk from Alec Stepanian Tufts MD PhD student at AHA Vascular Discovery Conference in Chicago showing his innovative mechanism for arterial thrombosis in cancer patients treated with Ponatinib. @TuftsMedicalCtr @TuftsMedSchool @MTChinMDPhD
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Fantastic talk from Alec Stepanian Tufts MD PhD student at AHA Vascular Discovery Conference in Chicago showing his innovative mechanism for arterial thrombosis in cancer patients treated with Ponatinib. @TuftsMedicalCtr @TuftsMedSchool @MTChinMDPhD
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Tufts MD PhD student Nicole Wolter gave a spectacular talk at the AHA Vascular Discovery Conference in Chicago. I couldn’t be more proud. @TuftsMedicalCtr @TuftsMedSchool @TuftsMCResearch @hboucher3 @MTChinMDPhD
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Fantastic talk by Oncology Fellow Ricky Travers at the AHA Vascular Discovery Conference in Chicago. @TuftsMedicalCtr @TuftsMCResearch @hboucher3 @KarenFreundMD
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Fantastic presentations by post doctoral fellow Jaime Ibarrola and MD PhD student Nick Camarda and AHA Vascular Discovery in Chicago. @TuftsMedicalCtr @TuftsMedSchool @TuftsMCResearch @hboucher3
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