#ISDP #Olympics . Spot diagnosis. Case 20 - @JCandidoXavier . CHROMOBLASTOMYCOSIS. •Pigmented (dematiaceous) fungi.•Prominent pseudoepitheliomatous hyperplasia.•Granulomatous infiltrates with round brownish Medlar bodies resembling copper pennies or coffee beans. #path #derm

#ISDP #Olympics . Spot diagnosis. Case 19 - @JoyceSSLee . SEBACEOUS CARCINOMA. • Periocular (75%).• Basophilic germinative sebaceous cells.• Sebocytes with vacuolated cytoplasm.• Nuclear pleomorphism.• Increased and atypical mitoses.• Necrosis. #Path #derm #pathology

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#ISDP #OlympicGames . Spot diagnosis. Case 18 - @JCandidoXavier . SYRINGOCYSTADENOMA PAPILLIFERUM. •It can occur in naevus sebaceus of Jadassohn.•Endophytic crateriform lesion.•Two layers of cells forming papillary and cystic structures.• Numerous plasma cells. #path #derm

#ISDP #OlympicGames . Spot diagnosis. Case 17 - @JoyceSSLee . CUTANEOUS ROSAI DORFMAN DISEASE. •Non-Langerhans cell histiocytosis.•Large histiocytes exhibiting emperipolesis (containing inflammatory cells).•CD68+, S100+, CD1a-.•Lymphoplasmacytic infiltrate. #Path #derm

#ISDP #Olympics . Spot diagnosis. Case 16 - @JCandidoXavier . ELASTOFIBROMA. •Benign soft tissue tumor characterized by abnormal elastic fibres and fibroblasts.•Hypocellular tumor with fragmented and thickened to globular elastic fibres. #Pathology #path #dermatology #derm

#ISDP #OlympicGames . Spot diagnosis. Case 15 - @JoyceSSLee . PLEVA:.•Parakeratosis.•Apoptotic keratinocytes .•Basal vacuolar alteration.•Dermal and intraepidermal hemorrhage.•Wedge-shaped lymphohistiocytic infiltrate.•+/- Lymphocytic vasculitis. #derm #path #pathology

#ISDP #OlympicGames . Spot diagnosis. Case 14 - @JCandidoXavier . PARACOCCIDIOIDOMYCOSIS. •Dimorphic fungi (mycelial in the environment and yeast in the host).•Granulomatous reaction pattern.•Round yeast with single or multiple buds with narrow necks. #derm #path #pathology

#ISDP #OlympicGames . Spot diagnosis. Case 13 - @JoyceSSLee . ONYCHOMATRICOMA. •Thickened nail plate.•Wormwood-like or honeycomb-like cavities.•Papillary digitate projections covered by matrix epithelium.•V-shaped keratogenouszones.•Fibrocellular stroma. #path #dermatology

#ISDP #OlympicGames . Spot diagnosis. Case 12 - @JCandidoXavier . LANGERHANS CELL HISTIOCYTOSIS. • Round/ovoid medium-sized cells with indented, lobulated or coffee-bean nuclei. • Abundant and eosinophilic cytoplasm .•IHQ markers: CD1a, Langerin and S100 protein. #derm #path

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#ISDP #Olympics . Spot diagnosis. Case 11 - @JoyceSSLee . NECROBIOTIC XANTHOGRANULOMA. •Areas of necrobiosis.•Xanthogranulomatousinflammation (foamy histiocytes, Touton giant cells).•Cholesterol clefts.•Large, bizarre angulated giant cells with many nuclei. #PathTwitter #derm

#ISDP #Olympics . Spot diagnosis. Case 10 - @JCandidoXavier . PSEUDOXANTHOMA ELASTICUM. • degenerative disease of elastic tissue . • autosomal dominant .• Elastic fibers are basophilic and irregular, appearing as widely dispersed granular material. #Path #dermpath #derm

#ISDP #Olympics2024 . Spot diagnosis. Case 9 - @JoyceSSLee . NECROTIZING INFUNDIBULAR CRYSTALLINE FOLLICULITIS. •Folliculocentric crater.•Eosinophilic filamentous material.•Material likely derived from Malassezia yeasts, bacteria, and/or sebaceous lipids. #path #dermatology

#ISDP #Olympics . Spot diagnosis . Case 8 - @JCandidoXavier. OCHRONOSIS. •Clinical presentation: blue–black cutaneous pigmentation . •Typical swollen, irregular, golden brown banana 🍌shaped, sickled or round ochronotic bodies . #dermpath #dermatology #pathology #path

#ISDP #Olympics . Spot diagnosis. Case 7 - @JoyceSSLee . HAND, FOOT AND MOUTH DISEASE. •Caused by coxsackievirus A16, enterovirus 71.•Intraepidermal blister.•Ballooning and reticular degeneration.•Epidermal necrosis.•Neutrophils. #Dermatology #derm #dempath #pathology

#ISDP #olympics. Spot diagnosis. Case 6 - @JCandidoXavier . GRANULAR CELL TUMOR. •Benign neuroectodermal tumor.•Large cells with abundant and granular cytoplasm.•Synonym: Abrikossoff tumor.•Pseudoepitheliomatous hyperplasia can be prominent. #path #pathology #dermatology

#ISDP #Olympics . Spot diagnosis . Case 5 - @JoyceSSLee . SCLEROMYXEDEMA. •Haphazard proliferation of fibroblasts within the reticular dermis.•Fibrosis and skin thickening.•Increased dermal mucin. #dermatology #dermatopatology #dermapath #path

#ISDP #Olympics . Spot diagnosis.Case 4 - @JCandidoXavier . EXTRAMAMMARY PAGET DISEASE. Intraepithelial proliferation of cells with vesicular nuclei and basophilic/amphophilic cytoplasm. Cells distributed in a solitary fashion or in nest/gland-like structures. #derm #path #med

#ISDP #Olympics2024. Spot diagnosis. Case 3 - @JoyceSSLee . BAP1-INACTIVATED MELANOCYTOMA. •Sporadic or germline.•Intradermal .•Large, epithelioid melanocytes.•Abundant eosinophilic cytoplasm.•Prominent nucleoli.•IHC: loss of nuclear BAP1 expression. #derm #path #dermpath

#ISDP #Olympics2024 . Spot diagnosis. Case 2 - @JCandidoXavier . ACQUIRED ELASTOTIC HEMANGIOMA. •Proliferation of vascular channels surrounded and intertwined by intense solar elastosis. •Erythematous lesions in sun-exposed areas of elderly patients. #pathology #medicine #derm