Hollenstein group
@Hollensteinlab
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Our group focuses on generating modified aptamers and developing chemoenzymatic methods for the synthesis of chemically modified, therapeutic oligonucleotides
Paris, France
Joined August 2017
Very happy to share our preprint @ChemRxiv on the selection of Ru-modified aptamers. Long in the making. Congrats to all authors. Great collaboration with @GasserGroup and @Chrom_Inf .@institutpasteur @CNRS.
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Very much looking forward presenting our research at #biotrans2025 in Basel. Thanks again for the kind invitation!
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Very happy to share out new pre-print on the enzymatic GalNAc-labelling of oligonucleotides. Big congrats to undergraduate student Elisa and graduate student @pierrenicolas_b !.@institutpasteur @CNRSchimie.
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RT @ChemEurope: #ChemBioChem #OnTheCover Recent Advances in Biocatalytic and Chemoenzymatic Synthesis of Oligonucleotides (ChemBioChem 9/20….
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RT @CNRSbiologie: ReNAissance : révolutionner les traitements antiviraux grâce à l’ARN messager . 🤝 @CNRSchimie @CNRS_dr17 @CNRS_Meudon .👉….
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RT @NatureBiotech: mRNA with engineered poly(A) tails produces prolonged higher levels of protein .
nature.com
Nature Biotechnology - mRNA with engineered poly(A) tails produces prolonged higher levels of protein.
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RT @ChemSocRev: Be sure to read "Natural, modified and conjugated carbohydrates in nucleic acids" by Debashis Dhara, Laurence A. Mulard and….
pubs.rsc.org
Storage of genetic information in DNA occurs through a unique ordering of canonical base pairs. However, this would not be possible in the absence of the sugar–phosphate backbone which is essential...
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Special thank to @ChemCommun editor Claire Harding, who strongly suggested transfer to @ChemSocRev after our submission!.
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Thrilled to share our article published @ChemSocRev on sugar modified nucleic acids. Congrats to @debashisdhara!.@Hollensteinlab @institutpasteur @DBSC_IP @CNRSchimie .
pubs.rsc.org
Storage of genetic information in DNA occurs through a unique ordering of canonical base pairs. However, this would not be possible in the absence of the sugar–phosphate backbone which is essential...
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Very happy to share our new preprint on the selection of COT-modified aptamers. Great work by undergraduate student Charlotte. Congrats to all!.Stay tuned for the published version. @institutpasteur @DBSC_IP @juliantanner1 @CNRSchimie.
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Happy to share a short interview (in french) on the synthesis of RNA oligonucleotides. Thanks @franceculture and @institutpasteur.
radiofrance.fr
AUDIO • Le corps en action : un parcours de santé, épisode : Katalin Karikó, la reine de l'ARNm. Une série inédite proposée par France Culture. Écoutez La Science, CQFD, et découvrez nos podcasts en...
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Very happy to share our recent review on biocatalytic approaches for the synthesis of oligonucleotides. Congrats to @pierrenicolas_b and @NazariiSabat .@DBSC_IP @institutpasteur @CNRSchimie .
chemistry-europe.onlinelibrary.wiley.com
The rapid increase in demand for longer and/or modified oligonucleotides calls for the development of improved strategies for their production. We review recent biocatalytic and chemoenzymatic...
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RT @nchembio: A new paper from @HoebartnerLab and @Uni_WUE reports the crystal structures of the ribozyme SAMURI, revealing the mechanism o….
nature.com
Nature Chemical Biology - Crystal structures of the ribozyme SAMURI reveal the alkyltransferase mechanism and show N3-modified adenosine and dealkylated cofactor in the active site, allowing for a...
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RT @perrinlab: And then the enantiomer of every other known antibiotic e.g. penicillin will be effective. Vaccines will work as well. A let….
science.org
Broad discussion is needed to chart a path forward
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RT @CHIMIA_journal: New issue of CHIMIA is out today. Check out the highlights from the new Swiss Chemical Society division of Materials Ch….
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RT @angew_chem: Selection of Plastic-Binding DNA Aptamers for Microplastics Detection (Juewen Liu and Co-Workers) @bionaloo @uWaterlooChem….
onlinelibrary.wiley.com
Through the systematic evolution of ligands by exponential enrichment (SELEX), a pyrimidine-rich DNA aptamer was isolated for PVS and PS microplastics, despite their different chemical structures....
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