Hollenstein group
@Hollensteinlab
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Our group focuses on generating modified aptamers and developing chemoenzymatic methods for the synthesis of chemically modified, therapeutic oligonucleotides
Paris, France
Joined August 2017
Thrilled to share our article just published in @J_A_C_S on the selection of Ru-modified aptamers! Fantastic collaboration with @Hollensteinlab, congratulations to all authors! https://t.co/HrYAbl0jwN
pubs.acs.org
Photodynamic therapy (PDT) harnesses the combination of light, oxygen, and photosensitizers to induce cell death via reactive oxygen species (ROS) formation. Given its intrinsic properties, PDT...
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Thrilled to share our article @J_A_C_S on the selection of Ru-modified aptamers! 7 years in the making. Congrats to all authors! Great collaboration with @GasserGroup
https://t.co/ybXH2foNDx
@GermainNiogret @institutpasteur
@pierrenicolas_b
pubs.acs.org
Photodynamic therapy (PDT) harnesses the combination of light, oxygen, and photosensitizers to induce cell death via reactive oxygen species (ROS) formation. Given its intrinsic properties, PDT...
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I'm very happy to announce that our article has just been published online in Communications Chemistry! Thank you @Hollensteinlab for giving me the opportunity to work on this project! 🧬 https://t.co/YD3juyK2hY
nature.com
Communications Chemistry - Chemical modifications of aptamers can enhance binding properties, however, the design of suitable functional groups remains challenging. Here, the authors introduce...
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Probing three-dimensional cyclooctatetraene for nucleobase modification in aptamer selection
nature.com
Communications Chemistry - Chemical modifications of aptamers can enhance binding properties, however, the design of suitable functional groups remains challenging. Here, the authors introduce...
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Interested by 3D modified aptamers? Then check out our recent article by undergraduate student Charlotte and postdoc Usman. https://t.co/3qgUvctEXK
@CNRS @institutpasteur @juliantanner1
nature.com
Communications Chemistry - Chemical modifications of aptamers can enhance binding properties, however, the design of suitable functional groups remains challenging. Here, the authors introduce...
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Very happy to share our preprint @ChemRxiv on the selection of Ru-modified aptamers. Long in the making. Congrats to all authors. Great collaboration with @GasserGroup and @Chrom_Inf
@institutpasteur @CNRS
https://t.co/HwSswhug1G
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Very much looking forward presenting our research at #biotrans2025 in Basel. Thanks again for the kind invitation!
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Very happy to share out new pre-print on the enzymatic GalNAc-labelling of oligonucleotides. Big congrats to undergraduate student Elisa and graduate student @pierrenicolas_b ! https://t.co/EIoFinvP7L
@institutpasteur @CNRSchimie
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#ChemBioChem #OnTheCover Recent Advances in Biocatalytic and Chemoenzymatic Synthesis of Oligonucleotides (ChemBioChem 9/2025) (Marcel Hollenstein and co-workers) https://t.co/g8XIIgLROS • https://t.co/xSdZZ8980A
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ReNAissance : révolutionner les traitements antiviraux grâce à l’ARN messager 🤝 @CNRSchimie @CNRS_dr17 @CNRS_Meudon 👉 https://t.co/eQxHIyyHX2
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mRNA with engineered poly(A) tails produces prolonged higher levels of protein https://t.co/DCaSDPBU9a
https://t.co/D0NV4nkeED
nature.com
Nature Biotechnology - mRNA with engineered poly(A) tails produces prolonged higher levels of protein.
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Be sure to read "Natural, modified and conjugated carbohydrates in nucleic acids" by Debashis Dhara, Laurence A. Mulard and Marcel Hollenstein @Hollensteinlab Read the #OpenAccess review here 👇 https://t.co/xgHelaq9RM
pubs.rsc.org
Storage of genetic information in DNA occurs through a unique ordering of canonical base pairs. However, this would not be possible in the absence of the sugar–phosphate backbone which is essential...
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Special thank to @ChemCommun editor Claire Harding, who strongly suggested transfer to @ChemSocRev after our submission!
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Thrilled to share our article published @ChemSocRev on sugar modified nucleic acids. Congrats to @debashisdhara! @Hollensteinlab @institutpasteur @DBSC_IP @CNRSchimie
pubs.rsc.org
Storage of genetic information in DNA occurs through a unique ordering of canonical base pairs. However, this would not be possible in the absence of the sugar–phosphate backbone which is essential...
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Very happy to share our new preprint on the selection of COT-modified aptamers. Great work by undergraduate student Charlotte. Congrats to all! https://t.co/41FzfWIFHy Stay tuned for the published version. @institutpasteur @DBSC_IP @juliantanner1 @CNRSchimie
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Happy to share a short interview (in french) on the synthesis of RNA oligonucleotides. Thanks @franceculture and @institutpasteur. https://t.co/O4TntYKPQJ
radiofrance.fr
AUDIO • Le corps en action : un parcours de santé, épisode : Katalin Karikó, la reine de l'ARNm. Une série inédite proposée par France Culture. Écoutez La Science, CQFD, et découvrez nos podcasts en...
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Thanks to Dr. Juan Jin and @RubenRagg @ChemBioChem for the kind invitation
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Very happy to share our recent review on biocatalytic approaches for the synthesis of oligonucleotides. Congrats to @pierrenicolas_b and @NazariiSabat
@DBSC_IP @institutpasteur @CNRSchimie
https://t.co/e6my6fkBOr
chemistry-europe.onlinelibrary.wiley.com
The rapid increase in demand for longer and/or modified oligonucleotides calls for the development of improved strategies for their production. We review recent biocatalytic and chemoenzymatic...
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A new paper from @HoebartnerLab and @Uni_WUE reports the crystal structures of the ribozyme SAMURI, revealing the mechanism of its methyltransferase activity and site-selectivity https://t.co/M6wg3J9uNm
nature.com
Nature Chemical Biology - Crystal structures of the ribozyme SAMURI reveal the alkyltransferase mechanism and show N3-modified adenosine and dealkylated cofactor in the active site, allowing for a...
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