Delighted to share our latest paper 'Severe dynein dysfunction in cholinergic neurons exacerbates ALS-like phenotypes in a new mouse model'. Read at .Funded by MND Association @mndassoc.

RT @SussexRNA: 🚀 Exciting new publication from the Hafezparast Lab! @ProfHafezparast .📄They explore how an ALS-associated TDP-43 mutation a….

Delighted to share our latest @DMM_Journal paper 'The ALS-associated TDP-43M337V mutation dysregulates microglia-derived extracellular microRNAs in a sex-specific manner'. Read at

RT @mndresearch: #ResearcherSpotlight💡. PhD student Sarah Gornall is investigating whether small changes in a combination of several genes….

Are you interested in discovering non-coding RNA biomarkers for early diagnosis of motor neuron disease? If yes, apply for a postdoc with us on a @LifeArc funded project @SussexNeuro @SussexLifeSci.

RT @SussexNeuro: Our Sussex Neuroscience 4-year PhD Programme is open for applications! Deadline Feb 19th, for Sept 2024 entry. Brilliant c….

RT @KatrinDeinhardt: We have a fully funded @SoCoBioDtp studentship advertised, together with my wonderful colleagues @TheWangLab and @Hafe….

Just a reminder that you have one week left to apply for this position in our group! Why not come join us on the South Coast to investigate biomarkers for MND?.

How would you like to come to @SussexLifeSci @SussexNeuro and work on a @mndresearch-funded project looking at identifying ncRNA biomarkers in MND using a clinical trial cohort? If that interests you, then come apply for a postdoc with us for two years!.

After seven years of incredible research into MND, Dr Greig Joilin is starting a new path as a lecturer. It has been an absolute pleasure to have him in my team & witness his exceptional talents & dedication to make a difference. Thank you Greig and all the very best for future!.

She interestingly found that mutant dynein with normal human TDP-43 showed no mislocalisation of the protein, but did show aggregation of TDP-43 in the spinal motor neurons, along with p62 upregulation. These findings provide new insights between dynein and TDP-43.

In work done by @EleniVChristof as part of her PhD, she investigated whether mice with mutations in both TDP-43 and dynein would cause TDP-43 cytoplasmic mislocalisation and protein aggregation, which although is a key ALS pathology, is not observed in most TDP-43 mouse models.

Proud to share our latest @tandfonline paper “Aberrant Dynein Function Promotes TDP-43 Aggregation and Upregulation of p62 in Male Mice Harboring Transgenic Human TDP-43.” Investigates axonal transport in #ALS. Read it at

RT @ProfHafezparast: A great pleasure to supervise our fantastic Sussex Neuroscience PhD student Eleni Christoforidou @EleniVChristof and t….

RT @SussexNeuro: Great opportunity to join our Neuroscience faculty (Research and Education Lectureship) at the University of Sussex: Deadl….

RT @mndresearch: Last night at the #ENCALS2023 poster session, the team caught up with a number of @mndassoc funded researchers! . Amazing….

RT @MNDoddie5: We've been catching up with @DrGreigJoilin & @hellychayts at ENCALS about their projects that were supported by the Foundati….

And so our time at #ENCALS2023 comes to an end. A great few days of networking, sharing our work, learning about the exciting work being done everywhere else, and enjoying the sunshine and hospitality in Barcelona!

So please come along, see what we found and have a chat with us - we'll try to be there while trying to catch a look at all the other exciting posters at #ENCALS2023!.

And lastly, we have @DrGreigJoilin who is presenting his @MNDoddie5 and @mndresearch funded work looking to find prognostic and progression non-coding RNA biomarkers using a longitudinal results and has some promising results.