📣 Our new lab homepage @Uni_MR is up and growing . #newPI #biosensors #Gproteins #signaling #GPCRs.

@AidaShahraki @schulte_lab @dahilger The resulting most potent ligand MR20 represents an important stepping stone for future ligand design for this underexplored receptor. We also hope that our study provides a blueprint for how ligands can be discovered for other poorly characterized #GPCRs.

Together with Martin Lohse, I designed the GPR3 sensor, Ainoleena Turku screened for ligands with input Peter Kolb & @AidaShahraki, and Maxi Rath &@SteffenPockes & team crafted a lot of derivatives. @schulte_lab and @dahilger provided infrastructure & many a helpful guidance.

Finding ligands for pharmacologically dark #GPCRs is not easy. But through a combined strategy of #biosensor design, virtual screening and medicinal chemistry it can be done! .Here's our latest preprint detailing the workflow for #GPR3:

Interested in doing a #PhD in the field of #cellbiology .and #pharmcology? We have an open PhD student position and develop novel optical to investigate how heterotrimeric #Gproteins enable #GPCR-specific signaling. Please repost :).

New G protein #biosensors #GCASE in the pipeline 😎. #newPI #GPCR #signaling #Gproteins

Fantastic review!.

Are you interested in #GPCR / #Gprotein signaling and #biosensor development? Then please apply for this open #PostDoc position in my new Emmy Noether Research Group @Uni_MR! . #newPI.

First data obtained with the new plate readers. Looking forward to more 🤓#newPI

Here's the link to the first PhD student position available in my group:

What a wonderful event! Looking forward to next year ☺️ thanks @dfg_public!.

📢I have open PhD student and Postdoc positions to join my #EmmyNoether lab to decipher how #GPCR-specific signaling is achieved by heterotrimeric #Gproteins! . ‼️Interested in developing novel biosensors💡 that reveal yet invisible states and processes🔍? ➡️DM or email me📨‼️.

Excited to participate in the Emmy Noether Meeting 2024! A beautiful symposium to hear about new DFG developments, connect with peers and learn how to manage EN projects. Thanks @dfg_public for organizing this wonderful event! . #newPI.

RT @PKameneva: I work hard now to set up the lab at @StAnna_CCRI and start the research on #pediatric_cancer #initiation using #iPSC models….

RT @AidaShahraki: Vey excited to be a part of the organization committee for the 4th Transatlantic GPCR symposium. Mark your calendar for….

@Uni_MR We will dive into the fascinating question how so many #GPCRs expressed in the same cell can activate the same #Gprotein but induce distinct signals and cellular responses! Interested? Please reach out ✉️.

I'm extremely honored and grateful to be awarded the competitive Emmy Noether Program to establish my own research lab @Uni_MR! .I'd like to thank all my past and present mentors and colleagues for the support I've received. Let's get this started #GPCRs #Gproteins #biosensors!.

I’m proud to become part of this fantastic #ECI seminar series! Tune in on 🗓️ June 13 ❗️to hear about our efforts in using a conformational GPR3 #biosensor to identify ligands for this orphan #GPCR.

That’s a fantastic postdoc opportunity! Isabella is a very kind and great scientist!.

RT @karantarina: Isabella was a fantastic mentor during my PhD! Here is a postdoc opportunity in her lab! :).