The first evidence of in vivo SARS-CoV-2 escape from antibodies: emergent Spike deletion H69/V70 and D796H mutation in a convalescent plasma (CP) treated patient. These mutations conferred reduced susceptibility to the CP and sera from multiple donors.

On Nov 10, @hkjcghi & @IVIHeadquarters hosted a symposium in Bangkok on pandemic preparedness—sharing lessons from COVID-19 and strategies for rapid research during emergencies. Key message: “No country is safe until all countries are safe.” #GlobalHealth #PandemicPreparedness

Some photos of the occasion

A real privilege as a member of @AHRI_News faculty to be hosted by the Malawi Liverpool Wellcome unit in Blantyre today. A world class research unit in the setting of significant health challenges: TB, HIV, malaria, respiratory and GI viral infections. @MedCambridge @hkjcghi

Wonderful to discuss our impactful team Science and receive invaluable guidance from the SAB at this meeting. We are emboldened to make ongoing contributions to pandemic preparedness @hkjcghi @MedCambridge @hkumed

📢 Join us for a symposium and panel discussion: Strengthening Pandemic Preparedness Through Shared Experiences Organized by The Hong Kong Jockey Club Global Health Institute and International Vaccine Institute (IVI) Registration: https://t.co/LcAKydtSof

Fantastic session on Mpox epidemiology, genomics and vaccines at the ISV vaccine meeting in Cape Town. Looking forward to meeting old and new collaborators for our work on Mpox vaccine responses in immune suppressed adults @hkjcghi @MedCambridge @IHVNigeria @DrAdamAbdullahi

It was a pleasure and honour to deliver my first lecture as co-director of @hkjcghi recently - link to the talks below. Really thrilled by the collective momentum behind our mission to prevent and contain pandemics and a huge thank you to our funders for making this possible

HKJCGHI hosted a dynamic public lecture featuring three Co-Directors on 17 Oct 2025 and emphasized our commitment to advancing global health through science, innovation, and international collaboration.🔗 Learn more: https://t.co/PvmVghCc08

This is amazing - a periodic table showing every element and how it’s used. Chemistry really is everywhere. 🔬✨ What’s your favorite element?

Exciting milestone for the @HKJC_Racing Global Health Institute 👏 Co-led by our @GuptaR_lab, the new joint lab at @hkumed will advance vaccine research and deepen collaboration across continents, strengthening our shared commitment to global health innovation. Read more👇

Incredibly proud to see the opening of @hkjcghi laboratory at @hkumed where @MedCambridge scientists will work alongside HKU colleagues to design and test vaccines for global preparedness efforts. We were privileged to have an array of high profile speakers to launch the event

There's a new BA.3.2.2 from South Africa today. For the most part, there's been little substantial change in BA.3.2 over the past few months—mostly synonymous mutations & very little happening in spike. But this new one has 3 spike mutations & looks quite interesting. 1/7

PSA: Stop calling macrophages in tissue M1 or M2. These are not states that exist in biology. The only use of M1 is a macrophage cultured ex vivo with LPS and IFNg; and for M2: IL-4/13/10. Macrophages in tissues are highly complex and diverse and do not resemble either of the

@Nucleocapsoid @RWittenbrink @GuptaR_lab & @yunlong_cao previously showed that for JN.1, heparan sulfate is crucial for infectivity—in contrast to other variants, for which it tended to lower infectivity—so I definitely think HS is important But the claims made here seem extreme &...

Special thanks to collaborators and support from @GuptaR_lab @MedCambridge @LawalSalako @nimrnigeria @babmaiyaki full report:

Thanks @GuptaR_lab @MedCambridge. Providing some additional commentary. 1. Delighted to share our study on fractional COVID-19 vaccine dosing in 🇳🇬. One big challenge during the pandemic was vaccine shortages. Could smaller doses help extend supplies without losing protection?

New work from our long-term collab with @GuptaR_lab from @Cambridge_Uni! His lab's awesome work, with our protein dynamics input, reveals how Spike P812S (fusion peptide) enables antibody escape by inducing protein instability @jesucastin @IGIBSocial https://t.co/eOEt9ifMa2

Our work on responses to COVID-19 vaccine in vulnerable populations continues. Here we show older individuals generate a lower non neutralising antibody response (ADCC) post dose 6 that correlates with lower levels of IgG1 -known to primarily mediate ADCC.

Pleased to share work from a large collaborative effort showing that fractional doses of COVID-19 vaccine elicit comparable neutralising antibody responses to variants of concern as full dose vaccine in the west African setting.

It was such a brilliant day and so lovely to see staff enjoying it and finding out more about how we can support them 🫶