Gupta Lab
@GuptaR_lab
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Ravi Gupta is Professor of Clinical Microbiology, University of Cambridge. TIME100 Most Influential 2020; Clarivate Highly Cited Researcher 2022-24 global lists
Cambridge, United Kingdom
Joined February 2017
The first evidence of in vivo SARS-CoV-2 escape from antibodies: emergent Spike deletion H69/V70 and D796H mutation in a convalescent plasma (CP) treated patient. These mutations conferred reduced susceptibility to the CP and sera from multiple donors.
medrxiv.org
SARS-CoV-2 Spike protein is critical for virus infection via engagement of ACE2, and amino acid variation in Spike is increasingly appreciated. Given both vaccines and therapeutics are designed...
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Our work on responses to COVID-19 vaccine in vulnerable populations continues. Here we show older individuals generate a lower non neutralising antibody response (ADCC) post dose 6 that correlates with lower levels of IgG1 -known to primarily mediate ADCC.
nature.com
npj Vaccines - Age-associated defect in ADCC response to COVID-19 vaccine
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Pleased to share work from a large collaborative effort showing that fractional doses of COVID-19 vaccine elicit comparable neutralising antibody responses to variants of concern as full dose vaccine in the west African setting.
nature.com
Scientific Reports - Safety and immunogenicity of fractional COVID-19 vaccine doses in Nigerian adults: A randomized non-inferiority trial
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RT @ACTcharity: It was such a brilliant day and so lovely to see staff enjoying it and finding out more about how we can support them 🫶.
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RT @AHRI_News: 📢 A big day for African health research: the African Population Cohorts Consortium has formally launched!. Hosted by @Scifor….
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RT @DrBike7: At the European HIV & Hepatitis European Meeting, Barcelona, a never-to-miss Congress with friends and passionates on HIV resi….
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Thrilled to have delivered a talk on innate immune cell cycle and viruses at the Singapore Society for Immunology Conference in my new role as co-director of the Hong Kong Jockey Club Global Health Institute. More discussions to follow as we develop our new institute in Asia.
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RT @yorgomodis: Our latest paper is out on MDA5 variants that increase risk of chronic inflammation but protect from autoimmune disease. Wo….
cell.com
Loss-of-function MDA5 variants increase the risk of chronic inflammation but protect against autoimmune disease. Singh et al. show that autoimmune-protective variants impair MDA5 signaling via...
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RT @Harvard: “No government—regardless of which party is in power—should dictate what private universities can teach, whom they can admit….
harvard.edu
No government—regardless of which party is in power—should dictate what private universities can teach, whom they can admit and hire, and which areas of study and inquiry they can pursue
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RT @JessicaMABlair: **NEW Doctoral Training Programme just launched!!** This exciting programme on Microbial Genomics for Health Protection….
birmingham.ac.uk
PhD in Microbial Genomics, exciting new Doctoral Training Programme in Microbial Genomics for Health Protection in collaboration with the UK Health Security Agency (UKHSA) launches
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RT @CVRinfo: 📃 NEW PUBLICATION | The immune system’s energy sensor revealed in new research. Research from Fletcher Lab shows that RNF213 s….
nature.com
Nature Communications - RNF213 is an E3 ligase with ATPase activity. Here, the authors show that RNF213 is activated by ATP binding and senses cellular energy states, and reveal a transthiolation...
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RT @ResFortnight: UK yet to reach former heights in winning Horizon Europe funds. The UK performed well in its first year back in the EU….
researchprofessionalnews.com
Nation currently ranked fifth on 2024 funding from EU research programme, with overall performance mixed
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RT @JeremyFarrar: In historic move, @WHO Member States approve 20% funding increase and 2026–27 budget
who.int
In a show of support for a sustainably financed World Health Organization, WHO Member States today approved a 20% increase in assessed contributions (membership dues) as they endorsed the Organizat...
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Incredibly honoured to be taking up an exciting new chair of Global Health here at Cambridge and co-directorship of the Hong Kong Jockey Club Global Health Institute based out of Hong Kong in partnership with HKU and International Vaccine Institute (IVI). @HKU_SPH @Cambridge_Uni.
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RT @Cambridge_Uni: Explore the Ray Dolby Centre, the state-of-the-art new home of the Cavendish Laboratory @DeptofPhysics and a major asse….
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RT @SpyrosLytras: We find that the closest-inferred ancestors of SARS-CoV-1 likely circulated in western China (Yunnan, Sichuan, or Guizhou….
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RT @angie_rasmussen: Beautiful work clarifying the evolutionary history of SARS-related CoVs as they circulated in their bat reservoirs acr….
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RT @LongDesertTrain: BA.2, driven to near-zero levels by BA.5, still haunt us, spawning monstrous viruses that, after vanishing for months,….
github.com
Description Sub-lineage of: BA.2 Earliest sequence: 2022-7-23, India, Rajasthan (Jodhpur) — EPI_ISL_14775115 Most recent sequence: 2022-8-5, India, Maharashtra (Pune) — EPI_ISL_14568402 Countries c...
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RT @PaulBalsom: No one talks about the garbage island in the Pacific. But it’s larger than France, Germany, and Spain combined. And it’s….
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