Granada Lab
@Granada_Lab
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Natural Scientists
Berlin, Germany
Joined February 2019
Major work out in @NaturePhysics!.Led by @NicaGutu & Malthe Nordentoft — a multi-lab collaboration. We show that the degree of circadian coherence between cells tunes proliferation rate 📈. Disrupting coupling breaks clock–cell cycle coordination. 👉
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RT @medicine_e: Stay up to date with the latest research from e:Med by e:Medium Flash, March edition .
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Huge team effort including @AnnaMarieFinge1, @CarolinEctor & many others — grateful for such a collaborative group. Very thoughtful reviewers’ feedback helped strengthen the work. Thanks to @medicine_e, @BMBF_Bund & @ChariteBerlin for supporting this project!.
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Our latest work is out in @CommsBio. Led by @NicaGutu & Hitoshi Ishikuma, we study how circadian rhythms shape time-of-day drug sensitivity in human cells 🕒💊. Toward time-based cancer therapy. Supported by @medicine_e, @BMBF_Bund @ChariteBerlin.👉
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Happy to share a new very exciting work from my lab! Congrats to @CarolinEctor and the team on their study of circadian clock dynamics in breast cancer cells, now published in @MolSystBiol. @medicine_e @ChariteBerlin funded by @BMBF_Bund.
Excited to announce that my second study with the @Granada_Lab, where we elucidated diverse circadian clock dynamics across breast cancer cells and their effect on drug sensitivity, has been published in @MolSystBiol. Thank you to the entire team!
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🚀 Together with @CarolinEctor, we recently published a review in Deutsches Ärzteblatt on Chronobiology in Oncology. Timing therapies for optimal effectiveness! ⏰💊.📌 Currently only in German. 🔗 #Oncology #Chronobiology #MedicalResearch #CancerTreatment.
aerzteblatt.de
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Exciting to see this out! Congrats to @Anton36193637 and @shaon_chak ! — fantastic work all around!.
Big shoutout to @Anton36193637, who drove this project over the last 4 years, working hard to make sense of all the noisy datasets using carefully designed models and statistical inference techniques. Thanks also to @Granada_Lab for the discussions and collaboration! (6/6).
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Thanks to @medicine_e, @BMBF_Bund, @ChariteBerlin. & @DKTK_ for the support! #CancerResearch #Chronotherapy.
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New Preprint from our lab, led by @CarolinEctor! We performed deep circadian phenotyping in breast cancer cell lines, uncovering circadian-based subtypes and showing the clock’s role in drug response, predicting drug sensitivity. #circadianbiology #breastcancer @BMBF_Bund.
Circadian clock features define novel breast cancer subtypes and shape drug sensitivity #biorxiv_cancer.
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Grateful for the excitement around our work on the best time-of-day for drug treatments! Thanks to everyone highlighting the emerging science of chronotherapy—a field built on the pioneering work of many we admire. News summary in 7 languages: @SRBRHQ.
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RT @CarolinEctor: Very nice article from @Inside_PM, highlighting our recent work published in @NatureComms:
insideprecisionmedicine.com
Combining live imaging with data analysis has allowed researchers to identify the best time of day to target breast cancer cells with specific drugs.
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RT @ChariteBerlin: Chemotherapie morgens, mittags oder besser abends? Forschende der #CharitéBerlin haben eine Methode entwickelt, mit der….
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RT @ChariteBerlin: Chemotherapy in the morning, at midday, or evening? Researchers at #CharitéBerlin have developed a method to determine t….
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New publication from our group! 🎉 Congrats to all authors, led by @CarolinEctor . We developed a method to use tumor cells' internal clocks to optimize cancer therapy. Thanks to @medicine_e , @BMBF_Bund , @ChariteBerlin & @DKTK_ for the support! #CancerResearch #Chronotherapy.
Excited to share the publication of my first paper in.@NatureComms, introducing a comprehensive approach to study time-of-day effects of anti-#cancer drugs ⏰ . Many thanks to the whole team, especially Adrián @Granada_Lab! Check out our work here:
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RT @medicine_e: News from the e:Med Research Community - e:Medium Newsletter Volume 7 is available here: #systemsme….
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RT @InSiDE_Seminar: THANK YOU!!!! to the AMAZING cell signaling community for a fantastic inaugural Dynamics and Encoding in Cell Signaling….
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Excited to present at #SRBR2024 @SRBR_Outreach! Join us Wednesday morning for Symposium 17 on Circadian Medicine. Grateful for the support from @medicine_e, @BMBF_Bund, and @ChariteBerlin. #CharitéBerlin.
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Finally out! "Circadian Coupling Orchestrates Cell Growth"! Our study shows how circadian synchronization impacts the coordination of cellular division, shaping collective growth dynamics. Kudos to @NicaGutu!
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Check out our latest pre-print! Kudos to Carolin Ector and a stellar team of collaborators for their immense effort. We've pioneered a novel high-throughput method to assess how circadian rhythms influence cellular response to drug perturbation.
biorxiv.org
The circadian clock, a fundamental biological regulator, governs essential cellular processes in health and disease. Circadian-based therapeutic strategies are increasingly gaining recognition as...
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